狗 拉布拉多寻回犬全色盲 2 型 (ACHM2-LR)

按品种或临床分类过滤 DNA 测试

Achromatopsia Type 2 (ACHM2) in Labrador Retrievers is a genetic condition causing complete color blindness and vision impairment. This DNA test identifies carriers and affected dogs, helping breeders make informed decisions to reduce the risk of passing ACHM2 to puppies. Early detection through genetic testing ensures better management and care for affected Labradors. By using the ACHM2 DNA test, breeders promote healthier bloodlines and improve the overall quality of life for their dogs. This test is essential for responsible Labrador Retriever breeding programs focused on eye health. Protect your Labrador’s vision with accurate ACHM2 genetic screening today. Stay informed and support canine genetic health with reliable DNA testing services.

缩写 ： ACHM2-LR

分析突变： CNGA3 c.1931_1933del

继承： 常染色体隐性遗传

可从包装中获取： Basic

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Introduction to Achromatopsia Type 2 in Labrador Retrievers

Achromatopsia Type 2 (ACHM2) is a genetic eye disorder that affects the vision of Labrador Retrievers. This condition results from mutations in the CNGB3 gene, which plays a crucial role in the function of photoreceptor cells in the retina. Affected dogs exhibit a range of visual impairments, primarily characterized by a lack of color vision and sensitivity to bright light.

Clinical Signs of ACHM2

Dogs with Achromatopsia Type 2 typically demonstrate several noticeable symptoms. These may include photophobia (aversion to bright light), nystagmus (involuntary eye movement), and reduced visual acuity. Owners may observe their pets having difficulty navigating in brightly lit environments or showing signs of discomfort in sunlight. The condition often leads to a significant reduction in the quality of life, as affected dogs may struggle with everyday activities.

Genetic Basis of ACHM2

The underlying cause of Achromatopsia Type 2 is linked to genetic mutations in the CNGB3 gene, which is essential for the normal functioning of cone photoreceptors in the retina. These photoreceptors are responsible for color vision and visual clarity. When the CNGB3 gene is mutated, it disrupts the normal signaling pathways, leading to the characteristic symptoms of achromatopsia. The condition follows an autosomal recessive inheritance pattern, meaning that both parents must carry the mutated gene for the offspring to be affected.

Diagnosis of ACHM2

Diagnosis of Achromatopsia Type 2 is typically confirmed through genetic testing. A DNA test can identify the presence of mutations in the CNGB3 gene, providing a definitive diagnosis. Early identification of the condition is crucial for managing the visual challenges faced by affected Labrador Retrievers. Regular veterinary check-ups and consultations with a veterinary ophthalmologist can help monitor the progression of the disease and address any complications that may arise.

受影响狗的管理和护理

While there is no cure for Achromatopsia Type 2, management strategies can help improve the quality of life for affected Labrador Retrievers. Owners are encouraged to create a safe and accommodating environment, minimizing exposure to bright lights and ensuring that their pets have a clear understanding of their surroundings. Additionally, training and behavioral modifications can assist these dogs in adapting to their visual limitations, allowing them to navigate their environments more confidently.

结论

Achromatopsia Type 2 is a significant genetic condition that affects the vision of Labrador Retrievers, resulting in challenges related to color perception and light sensitivity. Understanding the genetic basis and symptoms of this condition is vital for dog owners and breeders alike. With appropriate management and care, affected dogs can lead fulfilling lives despite their visual impairments.

被认可参加测试的品种： 拉布拉多寻回犬全色盲 2 型 (ACHM2-LR)

• Labrador Retriever

🧬 Interpretation of genotypes ACHM2-LR

❓ 了解有关基因型解释的更多信息

常见问题解答：理解解释

“清晰”是什么意思？

该动物不携带突变。就不会发展成这种疾病 并且不会将其传递下去。

“航母”是认真的吗？

不会。该动物通常是健康的，但可以将突变传播给它的 后代。

如果动物“受到影响”怎么办？

它携带两个突变的副本。预计临床症状取决于 这种疾病。它不应该被培育。

为什么男性/女性之间存在差异？

有些疾病与性别相关，因此其表现因性别而异 动物的性别。

预测后代

DNA 测试常见问题解答

这个 DNA 测试检测到什么？

This DNA test detects the mutation associated with Achromatopsia Type 2 In Labrador Retriever (ACHM2-LR) in order to identify clear, carrier, or at-risk animals.

为什么要测试繁殖动物？

DNA 测试有助于饲养员计划更安全的交配并降低将突变传播给后代的风险。

这个测试的继承模式是什么？

该测试报告的遗传模式是常染色体隐性遗传。

此测试分析哪种突变？

This test analyses the mutation CNGA3 c.1931_1933del.

携带动物是否必然受到影响？

未必。解释取决于遗传模式和产生的基因型。

参考

Tanaka Naoto, Dutrow Emily V, Miyadera Keiko, Delemotte Lucie, MacDermaid Christopher M, Reinstein Shelby L, Crumley William R, Dixon Christopher J, Casal Margret L, Klein Michael L, Aguirre Gustavo D, Tanaka Jacqueline C, Guziewicz Karina E. Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment. PLoS One. 2015 Sep 25;10(9):e0138943. doi: 10.1371/journal.pone.0138943. eCollection 2015.