狗 拉布拉多尋回犬 2 型冇色盲（ ACHM2-LR ）

按品種或臨床分類過濾 DNA 測試

Achromatopsia Type 2 (ACHM2) in Labrador Retrievers is a genetic condition causing complete color blindness and vision impairment. This DNA test identifies carriers and affected dogs, helping breeders make informed decisions to reduce the risk of passing ACHM2 to puppies. Early detection through genetic testing ensures better management and care for affected Labradors. By using the ACHM2 DNA test, breeders promote healthier bloodlines and improve the overall quality of life for their dogs. This test is essential for responsible Labrador Retriever breeding programs focused on eye health. Protect your Labrador’s vision with accurate ACHM2 genetic screening today. Stay informed and support canine genetic health with reliable DNA testing services.

縮寫： ACHM2-LR

分析咗嘅突變： CNGA3 c.1931_1933del

遺產 ： 常染色體隱性

喺包裝入面有得買： Basic

呢個 DNA 測試由我哋嘅包裝開始包括喺入面 Basic — 而且亦都係包嘅一部分 Basic, Standard, Advanced, Complete。

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揀最適合你嘅動物嘅繁殖或者健康策略嘅群體。

Introduction to Achromatopsia Type 2 in Labrador Retrievers

Achromatopsia Type 2 (ACHM2) is a genetic eye disorder that affects the vision of Labrador Retrievers. This condition results from mutations in the CNGB3 gene, which plays a crucial role in the function of photoreceptor cells in the retina. Affected dogs exhibit a range of visual impairments, primarily characterized by a lack of color vision and sensitivity to bright light.

Clinical Signs of ACHM2

Dogs with Achromatopsia Type 2 typically demonstrate several noticeable symptoms. These may include photophobia (aversion to bright light), nystagmus (involuntary eye movement), and reduced visual acuity. Owners may observe their pets having difficulty navigating in brightly lit environments or showing signs of discomfort in sunlight. The condition often leads to a significant reduction in the quality of life, as affected dogs may struggle with everyday activities.

Genetic Basis of ACHM2

The underlying cause of Achromatopsia Type 2 is linked to genetic mutations in the CNGB3 gene, which is essential for the normal functioning of cone photoreceptors in the retina. These photoreceptors are responsible for color vision and visual clarity. When the CNGB3 gene is mutated, it disrupts the normal signaling pathways, leading to the characteristic symptoms of achromatopsia. The condition follows an autosomal recessive inheritance pattern, meaning that both parents must carry the mutated gene for the offspring to be affected.

Diagnosis of ACHM2

Diagnosis of Achromatopsia Type 2 is typically confirmed through genetic testing. A DNA test can identify the presence of mutations in the CNGB3 gene, providing a definitive diagnosis. Early identification of the condition is crucial for managing the visual challenges faced by affected Labrador Retrievers. Regular veterinary check-ups and consultations with a veterinary ophthalmologist can help monitor the progression of the disease and address any complications that may arise.

Management and Care for Affected Dogs

While there is no cure for Achromatopsia Type 2, management strategies can help improve the quality of life for affected Labrador Retrievers. Owners are encouraged to create a safe and accommodating environment, minimizing exposure to bright lights and ensuring that their pets have a clear understanding of their surroundings. Additionally, training and behavioral modifications can assist these dogs in adapting to their visual limitations, allowing them to navigate their environments more confidently.

結論

Achromatopsia Type 2 is a significant genetic condition that affects the vision of Labrador Retrievers, resulting in challenges related to color perception and light sensitivity. Understanding the genetic basis and symptoms of this condition is vital for dog owners and breeders alike. With appropriate management and care, affected dogs can lead fulfilling lives despite their visual impairments.

測試認可嘅品種： 拉布拉多尋回犬 2 型冇色盲（ ACHM2-LR ）

• Labrador Retriever

🧬 Interpretation of genotypes ACHM2-LR

❓ 進一步了解基因型嘅解釋

常見問題：理解解釋

「清晰」係咩意思？

呢隻動物唔會攜帶呢個突變。佢唔會發病 同埋唔會傳落去。

「承載者」係咪認真？

唔係。隻動物一般都係健康嘅，但係可以將突變傳染畀佢 後代。

如果一隻動物係「受影響」嘅話點算好？

佢有兩個突變嘅副本。預計會有臨床症狀，視乎情況而定 個病。唔應該繁殖。

點解男 / 女有分別？

有啲疾病係同性別有關，所以佢哋嘅表現會因疾病而異 動物嘅性別。

預測後代

DNA 測試常見問題

呢個 DNA 測試可以檢測到啲咩？

This DNA test detects the mutation associated with Achromatopsia Type 2 In Labrador Retriever (ACHM2-LR) in order to identify clear, carrier, or at-risk animals.

點解要測試一隻繁殖動物？

DNA 檢測有助養殖者計劃更安全嘅交配，同埋減低將突變傳播畀後代嘅風險。

呢個測試嘅繼承模式係點？

呢個測試報告嘅遺傳模式係常染色體隱性。

呢個測試會分析邊個突變？

This test analyses the mutation CNGA3 c.1931_1933del.

載體動物係咪一定會受到影響？

唔一定。解釋取決於遺傳模式同所產生嘅基因型。

參考文獻

Tanaka Naoto, Dutrow Emily V, Miyadera Keiko, Delemotte Lucie, MacDermaid Christopher M, Reinstein Shelby L, Crumley William R, Dixon Christopher J, Casal Margret L, Klein Michael L, Aguirre Gustavo D, Tanaka Jacqueline C, Guziewicz Karina E. Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment. PLoS One. 2015 Sep 25;10(9):e0138943. doi: 10.1371/journal.pone.0138943. eCollection 2015.