Ce înseamnă „Clear”?
Animalul nu poartă mutația. Nu va dezvolta boala și nu o va transmite mai departe.
Cal Sindromul de insensibilitate la androgeni în varianta 2 pursânge (AIS-T2)
The Androgen Insensitivity Syndrome (AIS) Thoroughbred Variant 2 DNA test is a vital tool for horse breeders and veterinarians. This genetic test identifies carriers of AIS, a condition affecting male horses' development despite normal XY chromosomes. Early detection through the AIS Thoroughbred Variant 2 test helps prevent breeding affected stallions, ensuring healthier offspring and maintaining breed integrity. Utilizing this DNA test supports informed breeding decisions and promotes the overall well-being of Thoroughbred horses. Stay ahead in equine genetics by incorporating the AIS Thoroughbred Variant 2 test into your breeding program today. Accurate and reliable, this test is essential for responsible Thoroughbred management.
Abreviere: AIS-T2
Mutația analizată: AR c.2132C/T
Moștenire: X-Linked Recesiv
Acronim
AIS-T2
Frecvența observată
Severitate clinică
Clasificare clinică
Boli endocrine
Mutație analizată
AR c.2132C/T
p.(A711V)
p.(A711V)
Modul de moștenire
X-Linked Recesiv (Complet)
Rezumatul testului:
The DNA test for Androgen Insensitivity Syndrome in Thoroughbred Variant 2 (AIS) helps identify horses carrying a genetic mutation that affects sexual development. AIS causes affected horses, typically genetically male, to develop female characteristics despite having XY chromosomes. This condition can impact fertility and breeding decisions in Thoroughbred populations. Early detection through DNA testing allows breeders to make informed choices and manage affected horses appropriately. Overall, the AIS test is a valuable tool for maintaining the health and integrity of Thoroughbred bloodlines.
Disponibil din pachet: Basic
Acest test ADN este inclus începând din pachetul nostru Basic — și face parte și din pachete Basic, Standard, Advanced, Complete.
Vizualizați pachetele de teste ADN →Alege haita care se potrivește cel mai bine cu strategia ta de creștere sau de sănătate a animalelor tale.
Introduction to Androgen Insensitivity Syndrome in Thoroughbred Variant 2
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in individuals with XY chromosomes. In horses, particularly in the Thoroughbred breed, a specific variant known as Thoroughbred Variant 2 has been identified. This condition can have significant implications for horse breeding and performance.
Genetic Basis of AIS
AIS is caused by mutations in the androgen receptor gene, which results in a lack of response to androgens, the hormones responsible for male sexual development. In Thoroughbred Variant 2, the genetic mutation manifests in a manner that affects the horse's reproductive system and secondary sexual characteristics. Horses with this syndrome may appear externally female but possess XY chromosomes and internal male reproductive structures.
Clinical Manifestations
Horses affected by Thoroughbred Variant 2 typically display a range of clinical signs. These may include an absence of typical male reproductive organs, the presence of underdeveloped or abnormal genitalia, and a lack of behavioral traits typically associated with stallions. As a result, these horses may not be suitable for breeding purposes, leading to ethical and practical considerations in equine management.
Impact on Breeding and Performance
The presence of AIS in Thoroughbreds can significantly impact breeding programs. Understanding the genetic status of potential breeding stock is crucial for maintaining the integrity and quality of the breed. Horses identified as carriers of the AIS variant may be excluded from breeding to prevent the propagation of the condition, thus ensuring that the lineage remains strong and healthy.
Concluzie
Androgen Insensitivity Syndrome in Thoroughbred Variant 2 is a complex genetic condition that poses unique challenges for horse owners and breeders. By understanding the genetic underpinnings and clinical manifestations of this syndrome, stakeholders can make informed decisions that promote the health and viability of Thoroughbred horses. Ongoing research and genetic testing are essential for advancing knowledge and management practices related to AIS.
Rasa recunoscută pentru test: Sindromul de insensibilitate la androgeni în varianta 2 pursânge (AIS-T2)
- Thoroughbred
🧬 Interpretation of genotypes AIS-T2
Genotip
Stare
🟡 N/N
Non-transportator - Fără risc
❌ ♂ N/AIS-T2
Afectat - În pericol
🟡 ♀ N/AIS-T2
Transportator - Fără risc
❌ AIS-T2/AIS-T2
Afectat - În pericol
Întrebări frecvente: înțelegerea interpretării
Un „Carrier” este serios?
Nu. Animalul este în general sănătos, dar poate transmite mutația acestuia urmas.
Ce se întâmplă dacă un animal este „Afectat”?
Are două copii mutante. Se așteaptă semne clinice în funcție de boala. Nu trebuie crescut.
De ce există diferențe între bărbat/femeie?
Unele boli sunt legate de sex, astfel încât expresia lor variază în funcție de sexul animalului.
Prezice descendenții
N/N (netransportator)
N/AIS-T2 (Purtător)
AIS-T2/AIS-T2 (Afectat)
Întrebări frecvente despre testul ADN
Ce detectează acest test ADN?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Thoroughbred Variant 2 (AIS-T2) in order to identify clear, carrier, or at-risk animals.
De ce testați un animal de reproducție?
Testarea ADN îi ajută pe crescători să planifice împerecheri mai sigure și să reducă riscul de transmitere a mutației către descendenți.
Care este modul de moștenire al acestui test?
Modul de moștenire raportat pentru acest test este X-Linked Recessiv.
Ce mutație este analizată în acest test?
This test analyses the mutation AR c.2132C/T.
Este neapărat afectat un animal purtător?
Nu neapărat. Interpretarea depinde de modelul de moștenire și de genotipul rezultat.
Referințe
Villagomez Daniel A F, Welsford Eastman G, King W Allan, Revay Tamas. Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome. Genes (Basel). 2020 Jan 10;11(1):78. doi: 10.3390/genes11010078.