Chì significà "Clear"?
L'animali ùn porta micca a mutazione. Ùn svilupperà micca a malatia è ùn la trasmetterà.
cavallu Sindrome d'insensibilità à l'androgeni in a Variante Purosangue 2 (AIS-T2)
The Androgen Insensitivity Syndrome (AIS) Thoroughbred Variant 2 DNA test is a vital tool for horse breeders and veterinarians. This genetic test identifies carriers of AIS, a condition affecting male horses' development despite normal XY chromosomes. Early detection through the AIS Thoroughbred Variant 2 test helps prevent breeding affected stallions, ensuring healthier offspring and maintaining breed integrity. Utilizing this DNA test supports informed breeding decisions and promotes the overall well-being of Thoroughbred horses. Stay ahead in equine genetics by incorporating the AIS Thoroughbred Variant 2 test into your breeding program today. Accurate and reliable, this test is essential for responsible Thoroughbred management.
Abbreviazione: AIS-T2
mutazione analizzata: AR c.2132C/T
Eredità : X-Linked Recessive
Acronimu
AIS-T2
Frequenza osservata
Gravità clinica
Classificazione clinica
Malatie Endocrine
Mutazione analizata
AR c.2132C/T
p.(A711V)
p.(A711V)
Modu di l'eredi
X-Linked Recessive (Cumpletu)
Riassuntu di a prova:
The DNA test for Androgen Insensitivity Syndrome in Thoroughbred Variant 2 (AIS) helps identify horses carrying a genetic mutation that affects sexual development. AIS causes affected horses, typically genetically male, to develop female characteristics despite having XY chromosomes. This condition can impact fertility and breeding decisions in Thoroughbred populations. Early detection through DNA testing allows breeders to make informed choices and manage affected horses appropriately. Overall, the AIS test is a valuable tool for maintaining the health and integrity of Thoroughbred bloodlines.
Disponibile da u pacchettu: Basic
Questa prova di DNA hè inclusa partendu da u nostru pacchettu Basic — è hè ancu parte di i pacchetti Basic, Standard, Advanced, Complete.
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Introduction to Androgen Insensitivity Syndrome in Thoroughbred Variant 2
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in individuals with XY chromosomes. In horses, particularly in the Thoroughbred breed, a specific variant known as Thoroughbred Variant 2 has been identified. This condition can have significant implications for horse breeding and performance.
Genetic Basis of AIS
AIS is caused by mutations in the androgen receptor gene, which results in a lack of response to androgens, the hormones responsible for male sexual development. In Thoroughbred Variant 2, the genetic mutation manifests in a manner that affects the horse's reproductive system and secondary sexual characteristics. Horses with this syndrome may appear externally female but possess XY chromosomes and internal male reproductive structures.
Clinical Manifestations
Horses affected by Thoroughbred Variant 2 typically display a range of clinical signs. These may include an absence of typical male reproductive organs, the presence of underdeveloped or abnormal genitalia, and a lack of behavioral traits typically associated with stallions. As a result, these horses may not be suitable for breeding purposes, leading to ethical and practical considerations in equine management.
Impact on Breeding and Performance
The presence of AIS in Thoroughbreds can significantly impact breeding programs. Understanding the genetic status of potential breeding stock is crucial for maintaining the integrity and quality of the breed. Horses identified as carriers of the AIS variant may be excluded from breeding to prevent the propagation of the condition, thus ensuring that the lineage remains strong and healthy.
Cunclusioni
Androgen Insensitivity Syndrome in Thoroughbred Variant 2 is a complex genetic condition that poses unique challenges for horse owners and breeders. By understanding the genetic underpinnings and clinical manifestations of this syndrome, stakeholders can make informed decisions that promote the health and viability of Thoroughbred horses. Ongoing research and genetic testing are essential for advancing knowledge and management practices related to AIS.
Razza ricunnisciuta per a prova : Sindrome d'insensibilità à l'androgeni in a Variante Purosangue 2 (AIS-T2)
- Thoroughbred
🧬 Interpretation of genotypes AIS-T2
Genotipu
Status
🟡 N/N
Non trasportatore - Nisun Riscu
❌ ♂ N/AIS-T2
Affettatu - À Risicu
🟡 ♀ N/AIS-T2
Carrier - Nisun Riscu
❌ AIS-T2/AIS-T2
Affettatu - À Risicu
FAQ: capiscenu l'interpretazione
Hè un "Carrier" seriu?
No. L'animali hè generalmente sanu, ma pò trasmette a mutazione à u so prole.
E se un animale hè "Affettatu"?
Porta duie copie mutate. I segni clinichi sò previsti secondu a malatia. Ùn deve esse criatu.
Perchè ci sò differenze trà maschile / femina?
Alcune malatie sò ligati à u sessu, cusì a so espressione varieghja secondu u sessu di l'animali.
Prevede a prole
N/N (non-traspurtadore)
N/AIS-T2 (Carrier)
AIS-T2/AIS-T2 (Affettatu)
FAQ Test di DNA
Chì rileva stu test di DNA?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Thoroughbred Variant 2 (AIS-T2) in order to identify clear, carrier, or at-risk animals.
Perchè pruvà un animale di ripruduzzione?
A prova di DNA aiuta i criatori à pianificà accoppiamenti più sicuri è riduce u risicu di trasmette a mutazione à a prole.
Chì ghjè u modu di eredità di sta prova?
The inheritance mode reported for this test is X-Linked Recessive.
Quale mutazione hè analizata in questa prova?
This test analyses the mutation AR c.2132C/T.
Hè un animale trasportatore necessariamente affettatu?
Micca necessariamente. L'interpretazione dipende da u mudellu di eredità è u genotipu resultanti.
Referenze
Villagomez Daniel A F, Welsford Eastman G, King W Allan, Revay Tamas. Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome. Genes (Basel). 2020 Jan 10;11(1):78. doi: 10.3390/genes11010078.