Cosa significa "Chiaro"?
L'animale non porta la mutazione. Non svilupperà la malattia e non lo trasmetterò.
Cavallo Sindrome da insensibilità agli androgeni nella variante purosangue 2 (AIS-T2)
The Androgen Insensitivity Syndrome (AIS) Thoroughbred Variant 2 DNA test is a vital tool for horse breeders and veterinarians. This genetic test identifies carriers of AIS, a condition affecting male horses' development despite normal XY chromosomes. Early detection through the AIS Thoroughbred Variant 2 test helps prevent breeding affected stallions, ensuring healthier offspring and maintaining breed integrity. Utilizing this DNA test supports informed breeding decisions and promotes the overall well-being of Thoroughbred horses. Stay ahead in equine genetics by incorporating the AIS Thoroughbred Variant 2 test into your breeding program today. Accurate and reliable, this test is essential for responsible Thoroughbred management.
Abbreviazione: AIS-T2
Mutazione analizzata: AR c.2132C/T
Eredità: X-Linked Recessive
Acronimo
AIS-T2
Frequenza osservata
Gravità clinica
Classificazione clinica
Malattie endocrine
Mutazione analizzata
AR c.2132C/T
p.(A711V)
p.(A711V)
Modalità di ereditarietà
X-Linked Recessive (Completare)
Riepilogo del test:
The DNA test for Androgen Insensitivity Syndrome in Thoroughbred Variant 2 (AIS) helps identify horses carrying a genetic mutation that affects sexual development. AIS causes affected horses, typically genetically male, to develop female characteristics despite having XY chromosomes. This condition can impact fertility and breeding decisions in Thoroughbred populations. Early detection through DNA testing allows breeders to make informed choices and manage affected horses appropriately. Overall, the AIS test is a valuable tool for maintaining the health and integrity of Thoroughbred bloodlines.
Disponibile dalla confezione: Basic
Questo test del DNA è incluso a partire dalla nostra confezione Basic — e fa anche parte dei pack Basic, Standard, Advanced, Complete.
Visualizza i pacchetti di test del DNA →Scegli il pack che meglio si adatta alla tua strategia di allevamento o di salute dei tuoi animali.
Introduction to Androgen Insensitivity Syndrome in Thoroughbred Variant 2
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in individuals with XY chromosomes. In horses, particularly in the Thoroughbred breed, a specific variant known as Thoroughbred Variant 2 has been identified. This condition can have significant implications for horse breeding and performance.
Genetic Basis of AIS
AIS is caused by mutations in the androgen receptor gene, which results in a lack of response to androgens, the hormones responsible for male sexual development. In Thoroughbred Variant 2, the genetic mutation manifests in a manner that affects the horse's reproductive system and secondary sexual characteristics. Horses with this syndrome may appear externally female but possess XY chromosomes and internal male reproductive structures.
Clinical Manifestations
Horses affected by Thoroughbred Variant 2 typically display a range of clinical signs. These may include an absence of typical male reproductive organs, the presence of underdeveloped or abnormal genitalia, and a lack of behavioral traits typically associated with stallions. As a result, these horses may not be suitable for breeding purposes, leading to ethical and practical considerations in equine management.
Impact on Breeding and Performance
The presence of AIS in Thoroughbreds can significantly impact breeding programs. Understanding the genetic status of potential breeding stock is crucial for maintaining the integrity and quality of the breed. Horses identified as carriers of the AIS variant may be excluded from breeding to prevent the propagation of the condition, thus ensuring that the lineage remains strong and healthy.
Conclusione
Androgen Insensitivity Syndrome in Thoroughbred Variant 2 is a complex genetic condition that poses unique challenges for horse owners and breeders. By understanding the genetic underpinnings and clinical manifestations of this syndrome, stakeholders can make informed decisions that promote the health and viability of Thoroughbred horses. Ongoing research and genetic testing are essential for advancing knowledge and management practices related to AIS.
Razza riconosciuta per il test: Sindrome da insensibilità agli androgeni nella variante purosangue 2 (AIS-T2)
- Thoroughbred
🧬 Interpretation of genotypes AIS-T2
Genotipo
Stato
🟡 N/N
Non portatore: nessun rischio
❌ ♂ N/AIS-T2
Interessato - A rischio
🟡 ♀ N/AIS-T2
Vettore: nessun rischio
❌ AIS-T2/AIS-T2
Interessato - A rischio
FAQ: comprendere l'interpretazione
Un “Portatore” è serio?
No. L'animale è generalmente sano ma può trasmettergli la mutazione prole.
Cosa succede se un animale è “affetto”?
Porta due copie mutate. I segni clinici sono attesi a seconda la malattia. Non dovrebbe essere allevato.
Perché ci sono differenze tra maschio/femmina?
Alcune malattie sono legate al sesso, quindi la loro espressione varia a seconda sesso dell'animale.
Predire la prole
N/N (non-portatore)
N/AIS-T2 (Vettore)
AIS-T2/AIS-T2 (Ricercato)
Domande frequenti sul test del DNA
Cosa rileva questo test del DNA?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Thoroughbred Variant 2 (AIS-T2) in order to identify clear, carrier, or at-risk animals.
Perché testare un animale riproduttore?
Il test del DNA aiuta gli allevatori a pianificare accoppiamenti più sicuri e a ridurre il rischio di trasmettere la mutazione alla prole.
Qual è la modalità di ereditarietà di questo test?
The inheritance mode reported for this test is X-Linked Recessive.
Quale mutazione viene analizzata in questo test?
This test analyses the mutation AR c.2132C/T.
Un animale portatore è necessariamente affetto?
Non necessariamente. L'interpretazione dipende dal modello di ereditarietà e dal genotipo risultante.
Riferimenti
Villagomez Daniel A F, Welsford Eastman G, King W Allan, Revay Tamas. Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome. Genes (Basel). 2020 Jan 10;11(1):78. doi: 10.3390/genes11010078.