Hvad betyder "Ryd"?
Dyret bærer ikke mutationen. Det vil ikke udvikle sygdommen og vil ikke give det videre.
Hest Androgen Insensitivity Syndrome I Thoroughbred Variant 2 (AIS-T2)
The Androgen Insensitivity Syndrome (AIS) Thoroughbred Variant 2 DNA test is a vital tool for horse breeders and veterinarians. This genetic test identifies carriers of AIS, a condition affecting male horses' development despite normal XY chromosomes. Early detection through the AIS Thoroughbred Variant 2 test helps prevent breeding affected stallions, ensuring healthier offspring and maintaining breed integrity. Utilizing this DNA test supports informed breeding decisions and promotes the overall well-being of Thoroughbred horses. Stay ahead in equine genetics by incorporating the AIS Thoroughbred Variant 2 test into your breeding program today. Accurate and reliable, this test is essential for responsible Thoroughbred management.
Forkortelse: AIS-T2
Analyseret mutation: AR c.2132C/T
Arv: X-Linked recessiv
Akronym
AIS-T2
Observeret frekvens
Klinisk sværhedsgrad
Klinisk klassificering
Endokrine sygdomme
Analyseret mutation
AR c.2132C/T
p.(A711V)
p.(A711V)
Arvemåde
X-Linked recessiv (Complete)
Testresumé:
The DNA test for Androgen Insensitivity Syndrome in Thoroughbred Variant 2 (AIS) helps identify horses carrying a genetic mutation that affects sexual development. AIS causes affected horses, typically genetically male, to develop female characteristics despite having XY chromosomes. This condition can impact fertility and breeding decisions in Thoroughbred populations. Early detection through DNA testing allows breeders to make informed choices and manage affected horses appropriately. Overall, the AIS test is a valuable tool for maintaining the health and integrity of Thoroughbred bloodlines.
Tilgængelig fra pakken: Basic
Denne DNA-test er inkluderet fra vores pakke Basic — og er også en del af pakkerne Basic, Standard, Advanced, Complete.
Se DNA-testpakker →Vælg den flok, der passer bedst til din avls- eller sundhedsstrategi for dine dyr.
Introduction to Androgen Insensitivity Syndrome in Thoroughbred Variant 2
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in individuals with XY chromosomes. In horses, particularly in the Thoroughbred breed, a specific variant known as Thoroughbred Variant 2 has been identified. This condition can have significant implications for horse breeding and performance.
Genetic Basis of AIS
AIS is caused by mutations in the androgen receptor gene, which results in a lack of response to androgens, the hormones responsible for male sexual development. In Thoroughbred Variant 2, the genetic mutation manifests in a manner that affects the horse's reproductive system and secondary sexual characteristics. Horses with this syndrome may appear externally female but possess XY chromosomes and internal male reproductive structures.
Clinical Manifestations
Horses affected by Thoroughbred Variant 2 typically display a range of clinical signs. These may include an absence of typical male reproductive organs, the presence of underdeveloped or abnormal genitalia, and a lack of behavioral traits typically associated with stallions. As a result, these horses may not be suitable for breeding purposes, leading to ethical and practical considerations in equine management.
Impact on Breeding and Performance
The presence of AIS in Thoroughbreds can significantly impact breeding programs. Understanding the genetic status of potential breeding stock is crucial for maintaining the integrity and quality of the breed. Horses identified as carriers of the AIS variant may be excluded from breeding to prevent the propagation of the condition, thus ensuring that the lineage remains strong and healthy.
Konklusion
Androgen Insensitivity Syndrome in Thoroughbred Variant 2 is a complex genetic condition that poses unique challenges for horse owners and breeders. By understanding the genetic underpinnings and clinical manifestations of this syndrome, stakeholders can make informed decisions that promote the health and viability of Thoroughbred horses. Ongoing research and genetic testing are essential for advancing knowledge and management practices related to AIS.
Racen anerkendt til testen: Androgen Insensitivity Syndrome I Thoroughbred Variant 2 (AIS-T2)
- Thoroughbred
🧬 Interpretation of genotypes AIS-T2
Genotype
Status
🟡 N/N
Ikke-transportør - Ingen risiko
❌ ♂ N/AIS-T2
Berørt - i fare
🟡 ♀ N/AIS-T2
Transportør - Ingen risiko
❌ AIS-T2/AIS-T2
Berørt - i fare
FAQ: forstå fortolkningen
Er en "Carrier" seriøs?
Nej. Dyret er generelt sundt, men kan overføre mutationen til dens afkom.
Hvad hvis et dyr er "påvirket"?
Den bærer to muterede kopier. Kliniske tegn forventes afhængig af sygdommen. Det skal ikke avles.
Hvorfor er der forskel på mand/kvinde?
Nogle sygdomme er kønsbundne, så deres udtryk varierer afhængigt af dyrs køn.
Forudsig afkom
N/N (ikke-transportor)
N/AIS-T2 (Transportør)
AIS-T2/AIS-T2 (Påvirket)
Ofte stillede spørgsmål om DNA-test
Hvad opdager denne DNA-test?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Thoroughbred Variant 2 (AIS-T2) in order to identify clear, carrier, or at-risk animals.
Hvorfor teste et avlsdyr?
DNA-test hjælper opdrættere med at planlægge sikrere parringer og reducerer risikoen for at overføre mutationen til afkom.
Hvad er arvemetoden for denne test?
Den nedarvede tilstand, der er rapporteret for denne test, er X-Linked Recessive.
Hvilken mutation analyseres i denne test?
This test analyses the mutation AR c.2132C/T.
Er et bærende dyr nødvendigvis påvirket?
Ikke nødvendigvis. Fortolkningen afhænger af arvemønsteret og den resulterende genotype.
Referencer
Villagomez Daniel A F, Welsford Eastman G, King W Allan, Revay Tamas. Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome. Genes (Basel). 2020 Jan 10;11(1):78. doi: 10.3390/genes11010078.