狗 犬白细胞粘附缺陷 III 型 (CLAD3)

按品种或临床分类过滤 DNA 测试

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system, leading to severe infections and poor wound healing. A DNA test for CLAD3 helps identify carriers and affected dogs, enabling responsible breeding decisions to prevent the spread of this condition. Early detection through genetic testing is crucial for managing the health of at-risk breeds. By using a reliable CLAD3 DNA test, breeders and veterinarians can improve canine health outcomes and reduce the incidence of this immune deficiency. Protect your dog’s future with accurate genetic screening for CLAD3 today. Stay informed and ensure your dog’s well-being with advanced DNA testing options.

缩写 ： CLAD3

分析突变： FERMT3 c.1349_1350insAAGACGGCTGCC

继承： 常染色体隐性遗传

可从包装中获取： Basic

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Understanding Canine Leukocyte Adhesion Deficiency Type III (CLAD3)

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a genetic disorder that affects the immune system of dogs. This condition is characterized by a defect in the leukocyte adhesion process, which is critical for the proper functioning of the immune system. The deficiency disrupts the ability of white blood cells, or leukocytes, to adhere to blood vessel walls, preventing them from migrating to sites of infection or inflammation. As a result, affected dogs are more susceptible to infections and may experience chronic health issues.

Clinical Symptoms of CLAD3

Dogs with CLAD3 typically exhibit a range of clinical symptoms that are indicative of a compromised immune system. Common signs include recurrent infections, poor wound healing, and an increased frequency of inflammatory conditions. Affected dogs may also present with symptoms such as lethargy, fever, and swelling due to the inability of immune cells to effectively respond to pathogens.

Pathophysiology of CLAD3

The underlying cause of CLAD3 lies in a mutation within specific genes responsible for the production of adhesion molecules on leukocytes. These molecules are essential for the leukocyte's ability to stick to and traverse the endothelial cells lining blood vessels. When this adhesion process is impaired, the immune response is significantly weakened, leading to the clinical manifestations associated with the condition. This genetic mutation can lead to lifelong health challenges for affected dogs.

Diagnosis of CLAD3

Diagnosis of Canine Leukocyte Adhesion Deficiency Type III involves genetic testing to identify the specific mutation responsible for the condition. A DNA test can confirm the presence of the mutation, allowing for an accurate diagnosis. This diagnostic tool is particularly valuable for breeders and veterinarians, as it helps identify at-risk individuals and informs breeding decisions to reduce the prevalence of the disorder within certain populations.

管理和治疗方案

While there is currently no cure for CLAD3, management of affected dogs focuses on supporting their immune system and minimizing the risk of infections. This may include regular veterinary check-ups, prompt treatment of infections, and maintaining a clean environment to reduce exposure to pathogens. Additionally, owners may need to monitor their dogs closely for any signs of illness and seek veterinary care as needed.

结论

Canine Leukocyte Adhesion Deficiency Type III is a serious genetic disorder that poses significant challenges for affected dogs due to their compromised immune function. Understanding the condition, recognizing its symptoms, and pursuing genetic testing are crucial steps in managing the health of dogs at risk. By raising awareness and educating dog owners and breeders, it is possible to mitigate the impact of this condition on canine health.

被认可参加测试的品种： 犬白细胞粘附缺陷 III 型 (CLAD3)

• American White Shepherd Dog
• German Shepherd Dog
• Shiloh Shepherd
• Swiss White Shepherd Dog

🧬 Interpretation of genotypes CLAD3

❓ 了解有关基因型解释的更多信息

常见问题解答：理解解释

“清晰”是什么意思？

该动物不携带突变。就不会发展成这种疾病 并且不会将其传递下去。

“航母”是认真的吗？

不会。该动物通常是健康的，但可以将突变传播给它的 后代。

如果动物“受到影响”怎么办？

它携带两个突变的副本。预计临床症状取决于 这种疾病。它不应该被培育。

为什么男性/女性之间存在差异？

有些疾病与性别相关，因此其表现因性别而异 动物的性别。

预测后代

DNA 测试常见问题解答

这个 DNA 测试检测到什么？

This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3) in order to identify clear, carrier, or at-risk animals.

为什么要测试繁殖动物？

DNA 测试有助于饲养员计划更安全的交配并降低将突变传播给后代的风险。

这个测试的继承模式是什么？

该测试报告的遗传模式是常染色体隐性遗传。

此测试分析哪种突变？

This test analyses the mutation FERMT3 c.1349_1350insAAGACGGCTGCC.

携带动物是否必然受到影响？

未必。解释取决于遗传模式和产生的基因型。

参考

Boudreaux M K, Wardrop K J, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13.