「クリア」とはどういう意味ですか？
その動物は突然変異を持っていません。病気を発症することはありません そしてそれを伝えません。
犬 犬白血球接着不全タイプ III (CLAD3)
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system, leading to severe infections and poor wound healing. A DNA test for CLAD3 helps identify carriers and affected dogs, enabling responsible breeding decisions to prevent the spread of this condition. Early detection through genetic testing is crucial for managing the health of at-risk breeds. By using a reliable CLAD3 DNA test, breeders and veterinarians can improve canine health outcomes and reduce the incidence of this immune deficiency. Protect your dog’s future with accurate genetic screening for CLAD3 today. Stay informed and ensure your dog’s well-being with advanced DNA testing options.
略語 ： CLAD3
解析された変異: FERMT3 c.1349_1350insAAGACGGCTGCC
継承 ： 常染色体劣性
頭字語
CLAD3
観測周波数
臨床的重症度
臨床分類
免疫疾患
解析された変異
FERMT3 c.1349_1350insAAGACGGCTGCC
p.(L450_A451insRRLP)
p.(L450_A451insRRLP)
継承のモード
常染色体劣性 （完了）
テストの概要:
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system. It impairs the ability of white blood cells to adhere and migrate to infection sites, leading to severe and recurrent infections. A DNA test can identify carriers and affected dogs by detecting mutations responsible for CLAD3. Early diagnosis through testing helps breeders make informed decisions to reduce the spread of this condition. Managing affected dogs requires veterinary care to address infections and support immune function.
パックから入手可能: Basic
この DNA 検査はパックから含まれています Basic — これもパックの一部です Basic, Standard, Advanced, Complete。
DNA テスト パックを見る →動物の繁殖戦略や健康戦略に最適なパックをお選びください。
Understanding Canine Leukocyte Adhesion Deficiency Type III (CLAD3)
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a genetic disorder that affects the immune system of dogs. This condition is characterized by a defect in the leukocyte adhesion process, which is critical for the proper functioning of the immune system. The deficiency disrupts the ability of white blood cells, or leukocytes, to adhere to blood vessel walls, preventing them from migrating to sites of infection or inflammation. As a result, affected dogs are more susceptible to infections and may experience chronic health issues.
Clinical Symptoms of CLAD3
Dogs with CLAD3 typically exhibit a range of clinical symptoms that are indicative of a compromised immune system. Common signs include recurrent infections, poor wound healing, and an increased frequency of inflammatory conditions. Affected dogs may also present with symptoms such as lethargy, fever, and swelling due to the inability of immune cells to effectively respond to pathogens.
Pathophysiology of CLAD3
The underlying cause of CLAD3 lies in a mutation within specific genes responsible for the production of adhesion molecules on leukocytes. These molecules are essential for the leukocyte's ability to stick to and traverse the endothelial cells lining blood vessels. When this adhesion process is impaired, the immune response is significantly weakened, leading to the clinical manifestations associated with the condition. This genetic mutation can lead to lifelong health challenges for affected dogs.
Diagnosis of CLAD3
Diagnosis of Canine Leukocyte Adhesion Deficiency Type III involves genetic testing to identify the specific mutation responsible for the condition. A DNA test can confirm the presence of the mutation, allowing for an accurate diagnosis. This diagnostic tool is particularly valuable for breeders and veterinarians, as it helps identify at-risk individuals and informs breeding decisions to reduce the prevalence of the disorder within certain populations.
Management and Treatment Options
While there is currently no cure for CLAD3, management of affected dogs focuses on supporting their immune system and minimizing the risk of infections. This may include regular veterinary check-ups, prompt treatment of infections, and maintaining a clean environment to reduce exposure to pathogens. Additionally, owners may need to monitor their dogs closely for any signs of illness and seek veterinary care as needed.
結論
Canine Leukocyte Adhesion Deficiency Type III is a serious genetic disorder that poses significant challenges for affected dogs due to their compromised immune function. Understanding the condition, recognizing its symptoms, and pursuing genetic testing are crucial steps in managing the health of dogs at risk. By raising awareness and educating dog owners and breeders, it is possible to mitigate the impact of this condition on canine health.
試験に認められた品種: 犬白血球接着不全タイプ III (CLAD3)
- American White Shepherd Dog
- German Shepherd Dog
- Shiloh Shepherd
- Swiss White Shepherd Dog
🧬 Interpretation of genotypes CLAD3
遺伝子型
状態
🟡 N/N
ノンキャリア - リスクなし
🟡 N/CLAD3
キャリア - リスクなし
❌ CLAD3/CLAD3
影響を受ける – 危険にさらされる
FAQ: 解釈を理解する
「キャリア」って本気なの？
いいえ、その動物は通常健康ですが、突然変異をその動物に伝える可能性があります。 子孫。
動物が「影響を受けている」場合はどうなりますか?
それは2つの突然変異したコピーを持っています。臨床症状は以下に応じて予想されます 病気。飼育してはいけません。
なぜ男性/女性で違いがあるのでしょうか？
一部の病気は性と関連があるため、その発現は性別によって異なります。 動物の性別。
子孫を予測する
N/N (%e3%83%8e%e3%83%b3%e3%82%ad%e3%83%a3%e3%83%aa%e3%82%a2）
N/CLAD3 (キャリア）
CLAD3/CLAD3 (影響を受ける）
DNA検査に関するよくある質問
この DNA 検査では何が検出されますか?
This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3) in order to identify clear, carrier, or at-risk animals.
なぜ繁殖動物を検査するのでしょうか?
DNA検査は、ブリーダーがより安全な交配を計画し、子孫に突然変異が伝わるリスクを軽減するのに役立ちます。
このテストの継承モードは何ですか?
このテストで報告される継承モードは常染色体劣性です。
このテストではどの変異が分析されますか?
This test analyses the mutation FERMT3 c.1349_1350insAAGACGGCTGCC.
保菌動物は必ず影響を受けますか?
必ずしもそうとは限りません。解釈は、遺伝パターンと結果として生じる遺伝子型によって異なります。
参考文献
Boudreaux M K, Wardrop K J, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13.