Apakah maksud "Jelas"?
Haiwan itu tidak membawa mutasi. Ia tidak akan membangunkan penyakit ini dan tidak akan meneruskannya.
anjing Kekurangan Lekatan Leukosit Anjing Jenis III (CLAD3)
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system, leading to severe infections and poor wound healing. A DNA test for CLAD3 helps identify carriers and affected dogs, enabling responsible breeding decisions to prevent the spread of this condition. Early detection through genetic testing is crucial for managing the health of at-risk breeds. By using a reliable CLAD3 DNA test, breeders and veterinarians can improve canine health outcomes and reduce the incidence of this immune deficiency. Protect your dog’s future with accurate genetic screening for CLAD3 today. Stay informed and ensure your dog’s well-being with advanced DNA testing options.
Singkatan : CLAD3
Mutasi yang dianalisis: FERMT3 c.1349_1350insAAGACGGCTGCC
Warisan : Autosomal Resesif
Akronim
CLAD3
Kekerapan diperhatikan
Keterukan klinikal
Klasifikasi klinikal
Penyakit Imunologi
Mutasi yang dianalisis
FERMT3 c.1349_1350insAAGACGGCTGCC
p.(L450_A451insRRLP)
p.(L450_A451insRRLP)
Cara pewarisan
Autosomal Resesif (Lengkap)
Ringkasan ujian:
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system. It impairs the ability of white blood cells to adhere and migrate to infection sites, leading to severe and recurrent infections. A DNA test can identify carriers and affected dogs by detecting mutations responsible for CLAD3. Early diagnosis through testing helps breeders make informed decisions to reduce the spread of this condition. Managing affected dogs requires veterinary care to address infections and support immune function.
Tersedia dari pek: Basic
Ujian DNA ini disertakan bermula dari pek kami Basic — dan juga merupakan sebahagian daripada pek Basic, Standard, Advanced, Complete.
Lihat Pek Ujian DNA →Pilih pek yang paling sesuai dengan strategi pembiakan atau kesihatan haiwan anda.
Understanding Canine Leukocyte Adhesion Deficiency Type III (CLAD3)
Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a genetic disorder that affects the immune system of dogs. This condition is characterized by a defect in the leukocyte adhesion process, which is critical for the proper functioning of the immune system. The deficiency disrupts the ability of white blood cells, or leukocytes, to adhere to blood vessel walls, preventing them from migrating to sites of infection or inflammation. As a result, affected dogs are more susceptible to infections and may experience chronic health issues.
Clinical Symptoms of CLAD3
Dogs with CLAD3 typically exhibit a range of clinical symptoms that are indicative of a compromised immune system. Common signs include recurrent infections, poor wound healing, and an increased frequency of inflammatory conditions. Affected dogs may also present with symptoms such as lethargy, fever, and swelling due to the inability of immune cells to effectively respond to pathogens.
Pathophysiology of CLAD3
The underlying cause of CLAD3 lies in a mutation within specific genes responsible for the production of adhesion molecules on leukocytes. These molecules are essential for the leukocyte's ability to stick to and traverse the endothelial cells lining blood vessels. When this adhesion process is impaired, the immune response is significantly weakened, leading to the clinical manifestations associated with the condition. This genetic mutation can lead to lifelong health challenges for affected dogs.
Diagnosis of CLAD3
Diagnosis of Canine Leukocyte Adhesion Deficiency Type III involves genetic testing to identify the specific mutation responsible for the condition. A DNA test can confirm the presence of the mutation, allowing for an accurate diagnosis. This diagnostic tool is particularly valuable for breeders and veterinarians, as it helps identify at-risk individuals and informs breeding decisions to reduce the prevalence of the disorder within certain populations.
Pilihan Pengurusan dan Rawatan
While there is currently no cure for CLAD3, management of affected dogs focuses on supporting their immune system and minimizing the risk of infections. This may include regular veterinary check-ups, prompt treatment of infections, and maintaining a clean environment to reduce exposure to pathogens. Additionally, owners may need to monitor their dogs closely for any signs of illness and seek veterinary care as needed.
Kesimpulan
Canine Leukocyte Adhesion Deficiency Type III is a serious genetic disorder that poses significant challenges for affected dogs due to their compromised immune function. Understanding the condition, recognizing its symptoms, and pursuing genetic testing are crucial steps in managing the health of dogs at risk. By raising awareness and educating dog owners and breeders, it is possible to mitigate the impact of this condition on canine health.
Baka yang diiktiraf untuk ujian: Kekurangan Lekatan Leukosit Anjing Jenis III (CLAD3)
- American White Shepherd Dog
- German Shepherd Dog
- Shiloh Shepherd
- Swiss White Shepherd Dog
🧬 Interpretation of genotypes CLAD3
Genotip
Status
🟡 N/N
Bukan pembawa - Tiada Risiko
🟡 N/CLAD3
Pembawa - Tiada Risiko
❌ CLAD3/CLAD3
Terjejas - Berisiko
FAQ: memahami tafsiran
Adakah "Pembawa" serius?
Tidak. Haiwan itu secara amnya sihat tetapi boleh menghantar mutasi kepada haiwan itu zuriat.
Bagaimana jika haiwan "Terjejas"?
Ia membawa dua salinan bermutasi. Tanda-tanda klinikal dijangka bergantung kepada penyakit itu. Ia tidak sepatutnya dibiakkan.
Mengapa terdapat perbezaan antara lelaki / perempuan?
Sesetengah penyakit adalah berkaitan seks, jadi ekspresi mereka berbeza-beza bergantung pada seks haiwan.
Ramalkan Keturunan
N/N (bukan-pembawa)
N/CLAD3 (Pembawa)
CLAD3/CLAD3 (Terpengaruh)
Soalan Lazim Ujian DNA
Apakah yang dikesan oleh ujian DNA ini?
This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3) in order to identify clear, carrier, or at-risk animals.
Mengapa menguji haiwan pembiakan?
Ujian DNA membantu penternak merancang perkahwinan yang lebih selamat dan mengurangkan risiko penghantaran mutasi kepada anak.
Apakah mod pewarisan ujian ini?
Mod pewarisan yang dilaporkan untuk ujian ini ialah Autosomal Resesif.
Mutasi manakah yang dianalisis dalam ujian ini?
This test analyses the mutation FERMT3 c.1349_1350insAAGACGGCTGCC.
Adakah haiwan pembawa semestinya terjejas?
Tidak semestinya. Tafsiran bergantung pada corak pewarisan dan genotip yang terhasil.
Rujukan
Boudreaux M K, Wardrop K J, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13.