狗 Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3)

按品種或臨床分類過濾 DNA 測試

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system, leading to severe infections and poor wound healing. A DNA test for CLAD3 helps identify carriers and affected dogs, enabling responsible breeding decisions to prevent the spread of this condition. Early detection through genetic testing is crucial for managing the health of at-risk breeds. By using a reliable CLAD3 DNA test, breeders and veterinarians can improve canine health outcomes and reduce the incidence of this immune deficiency. Protect your dog’s future with accurate genetic screening for CLAD3 today. Stay informed and ensure your dog’s well-being with advanced DNA testing options.

縮寫： CLAD3

分析咗嘅突變： FERMT3 c.1349_1350insAAGACGGCTGCC

遺產 ： 常染色體隱性

喺包裝入面有得買： Basic

呢個 DNA 測試由我哋嘅包裝開始包括喺入面 Basic — 而且亦都係包嘅一部分 Basic, Standard, Advanced, Complete。

查看 DNA 檢測包 →

揀最適合你嘅動物嘅繁殖或者健康策略嘅群體。

Understanding Canine Leukocyte Adhesion Deficiency Type III (CLAD3)

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a genetic disorder that affects the immune system of dogs. This condition is characterized by a defect in the leukocyte adhesion process, which is critical for the proper functioning of the immune system. The deficiency disrupts the ability of white blood cells, or leukocytes, to adhere to blood vessel walls, preventing them from migrating to sites of infection or inflammation. As a result, affected dogs are more susceptible to infections and may experience chronic health issues.

Clinical Symptoms of CLAD3

Dogs with CLAD3 typically exhibit a range of clinical symptoms that are indicative of a compromised immune system. Common signs include recurrent infections, poor wound healing, and an increased frequency of inflammatory conditions. Affected dogs may also present with symptoms such as lethargy, fever, and swelling due to the inability of immune cells to effectively respond to pathogens.

Pathophysiology of CLAD3

The underlying cause of CLAD3 lies in a mutation within specific genes responsible for the production of adhesion molecules on leukocytes. These molecules are essential for the leukocyte's ability to stick to and traverse the endothelial cells lining blood vessels. When this adhesion process is impaired, the immune response is significantly weakened, leading to the clinical manifestations associated with the condition. This genetic mutation can lead to lifelong health challenges for affected dogs.

Diagnosis of CLAD3

Diagnosis of Canine Leukocyte Adhesion Deficiency Type III involves genetic testing to identify the specific mutation responsible for the condition. A DNA test can confirm the presence of the mutation, allowing for an accurate diagnosis. This diagnostic tool is particularly valuable for breeders and veterinarians, as it helps identify at-risk individuals and informs breeding decisions to reduce the prevalence of the disorder within certain populations.

管理同治療選項

While there is currently no cure for CLAD3, management of affected dogs focuses on supporting their immune system and minimizing the risk of infections. This may include regular veterinary check-ups, prompt treatment of infections, and maintaining a clean environment to reduce exposure to pathogens. Additionally, owners may need to monitor their dogs closely for any signs of illness and seek veterinary care as needed.

結論

Canine Leukocyte Adhesion Deficiency Type III is a serious genetic disorder that poses significant challenges for affected dogs due to their compromised immune function. Understanding the condition, recognizing its symptoms, and pursuing genetic testing are crucial steps in managing the health of dogs at risk. By raising awareness and educating dog owners and breeders, it is possible to mitigate the impact of this condition on canine health.

測試認可嘅品種： Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3)

• American White Shepherd Dog
• German Shepherd Dog
• Shiloh Shepherd
• Swiss White Shepherd Dog

🧬 Interpretation of genotypes CLAD3

❓ 進一步了解基因型嘅解釋

常見問題：理解解釋

「清晰」係咩意思？

呢隻動物唔會攜帶呢個突變。佢唔會發病 同埋唔會傳落去。

「承載者」係咪認真？

唔係。隻動物一般都係健康嘅，但係可以將突變傳染畀佢 後代。

如果一隻動物係「受影響」嘅話點算好？

佢有兩個突變嘅副本。預計會有臨床症狀，視乎情況而定 個病。唔應該繁殖。

點解男 / 女有分別？

有啲疾病係同性別有關，所以佢哋嘅表現會因疾病而異 動物嘅性別。

預測後代

DNA 測試常見問題

呢個 DNA 測試可以檢測到啲咩？

This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3) in order to identify clear, carrier, or at-risk animals.

點解要測試一隻繁殖動物？

DNA 檢測有助養殖者計劃更安全嘅交配，同埋減低將突變傳播畀後代嘅風險。

呢個測試嘅繼承模式係點？

呢個測試報告嘅遺傳模式係常染色體隱性。

呢個測試會分析邊個突變？

This test analyses the mutation FERMT3 c.1349_1350insAAGACGGCTGCC.

載體動物係咪一定會受到影響？

唔一定。解釋取決於遺傳模式同所產生嘅基因型。

參考文獻

Boudreaux M K, Wardrop K J, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13.