狗 犬白血球黏附缺陷 III 型 (CLAD3)

依品種或臨床分類過濾 DNA 測試

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a rare genetic disorder affecting a dog’s immune system, leading to severe infections and poor wound healing. A DNA test for CLAD3 helps identify carriers and affected dogs, enabling responsible breeding decisions to prevent the spread of this condition. Early detection through genetic testing is crucial for managing the health of at-risk breeds. By using a reliable CLAD3 DNA test, breeders and veterinarians can improve canine health outcomes and reduce the incidence of this immune deficiency. Protect your dog’s future with accurate genetic screening for CLAD3 today. Stay informed and ensure your dog’s well-being with advanced DNA testing options.

縮寫 ： CLAD3

分析突變： FERMT3 c.1349_1350insAAGACGGCTGCC

繼承： 體染色體隱性遺傳

可從包裝中取得： Basic

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Understanding Canine Leukocyte Adhesion Deficiency Type III (CLAD3)

Canine Leukocyte Adhesion Deficiency Type III (CLAD3) is a genetic disorder that affects the immune system of dogs. This condition is characterized by a defect in the leukocyte adhesion process, which is critical for the proper functioning of the immune system. The deficiency disrupts the ability of white blood cells, or leukocytes, to adhere to blood vessel walls, preventing them from migrating to sites of infection or inflammation. As a result, affected dogs are more susceptible to infections and may experience chronic health issues.

Clinical Symptoms of CLAD3

Dogs with CLAD3 typically exhibit a range of clinical symptoms that are indicative of a compromised immune system. Common signs include recurrent infections, poor wound healing, and an increased frequency of inflammatory conditions. Affected dogs may also present with symptoms such as lethargy, fever, and swelling due to the inability of immune cells to effectively respond to pathogens.

Pathophysiology of CLAD3

The underlying cause of CLAD3 lies in a mutation within specific genes responsible for the production of adhesion molecules on leukocytes. These molecules are essential for the leukocyte's ability to stick to and traverse the endothelial cells lining blood vessels. When this adhesion process is impaired, the immune response is significantly weakened, leading to the clinical manifestations associated with the condition. This genetic mutation can lead to lifelong health challenges for affected dogs.

Diagnosis of CLAD3

Diagnosis of Canine Leukocyte Adhesion Deficiency Type III involves genetic testing to identify the specific mutation responsible for the condition. A DNA test can confirm the presence of the mutation, allowing for an accurate diagnosis. This diagnostic tool is particularly valuable for breeders and veterinarians, as it helps identify at-risk individuals and informs breeding decisions to reduce the prevalence of the disorder within certain populations.

管理和治療方案

While there is currently no cure for CLAD3, management of affected dogs focuses on supporting their immune system and minimizing the risk of infections. This may include regular veterinary check-ups, prompt treatment of infections, and maintaining a clean environment to reduce exposure to pathogens. Additionally, owners may need to monitor their dogs closely for any signs of illness and seek veterinary care as needed.

結論

Canine Leukocyte Adhesion Deficiency Type III is a serious genetic disorder that poses significant challenges for affected dogs due to their compromised immune function. Understanding the condition, recognizing its symptoms, and pursuing genetic testing are crucial steps in managing the health of dogs at risk. By raising awareness and educating dog owners and breeders, it is possible to mitigate the impact of this condition on canine health.

被認可參加測試的品種： 犬白血球黏附缺陷 III 型 (CLAD3)

• American White Shepherd Dog
• German Shepherd Dog
• Shiloh Shepherd
• Swiss White Shepherd Dog

🧬 Interpretation of genotypes CLAD3

❓ 了解有關基因型解釋的更多信息

常見問題：理解解釋

「清晰」是什麼意思？

該動物不攜帶突變。就不會發展成這種疾病 並且不會傳遞下去。

「航母」是認真的嗎？

不會。該動物通常是健康的，但可以將突變傳播給它的 後代。

如果動物「受到影響」怎麼辦？

它攜帶兩個突變的副本。預計臨床症狀取決於 這種疾病。它不應該被培育。

為什麼男性/女性之間會有差異？

有些疾病與性別有關，因此其表現因性別而異 動物的性別。

預測後代

DNA 測試常見問題解答

這個 DNA 測試檢測到什麼？

This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency Type Iii (CLAD3) in order to identify clear, carrier, or at-risk animals.

為什麼要測試繁殖動物？

DNA 測試有助於飼養員計劃更安全的交配並降低將突變傳播給後代的風險。

這個測試的​​繼承模式是什麼？

此測試報告的遺傳模式是體染色體隱性遺傳。

此測試分析哪一種突變？

This test analyses the mutation FERMT3 c.1349_1350insAAGACGGCTGCC.

攜帶動物是否必然受到影響？

未必。解釋取決於遺傳模式和產生的基因型。

參考

Boudreaux M K, Wardrop K J, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13.