狗 无纤维蛋白原血症 (AF)

按品种或临床分类过滤 DNA 测试

Afibrinogenaemia in dogs is a rare but serious genetic disorder affecting blood clotting. A DNA test for afibrinogenaemia can help identify carriers and affected dogs, ensuring early diagnosis and management. Symptoms may include excessive bleeding, prolonged recovery from injuries, and spontaneous hemorrhages. By understanding the genetic basis of this condition, breeders can make informed decisions to prevent its occurrence in future litters. If you suspect your dog may have afibrinogenaemia, consult your veterinarian for testing options. Early intervention can significantly improve your dog's quality of life. Protect your furry friend by considering a DNA test today!

缩写 ： AF

分析突变： FGA c.1665delT

继承： 常染色体隐性遗传

可从包装中获取： Basic

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Understanding Afibrinogenaemia in Dogs

Afibrinogenaemia is a rare genetic disorder characterized by the absence of fibrinogen, a crucial protein involved in the blood coagulation process. This condition can lead to severe bleeding episodes, making it a significant health concern for affected dogs. The lack of fibrinogen impairs the body's ability to form blood clots, which is essential for stopping bleeding following an injury or during surgical procedures.

Genetic Basis of Afibrinogenaemia

The condition is caused by mutations in the FGA gene, which is responsible for producing fibrinogen. These mutations can lead to a complete absence of fibrinogen in the blood, resulting in the clinical manifestation of afibrinogenaemia. The genetic nature of this disorder means that it can be inherited, and identifying carriers of the mutation is crucial for breeding decisions to prevent the propagation of this trait.

临床体征和症状

Dogs with afibrinogenaemia may present with various clinical signs, primarily related to bleeding. Common symptoms include spontaneous bruising, prolonged bleeding from minor wounds, and excessive bleeding during or after surgical procedures. Some dogs may also experience internal bleeding, which can manifest as weakness, lethargy, or an increased heart rate. It's essential for pet owners to recognize these signs and seek veterinary attention promptly.

Diagnosis of Afibrinogenaemia

Diagnosis typically involves a combination of clinical evaluation and laboratory tests. Blood tests can reveal low or absent levels of fibrinogen, and additional coagulation studies may be performed to assess the overall clotting ability of the blood. In some cases, a DNA test can confirm the presence of mutations associated with afibrinogenaemia, providing a definitive diagnosis.

管理和治疗方案

While there is no cure for afibrinogenaemia, management focuses on preventing and controlling bleeding episodes. This may include the use of blood transfusions to provide necessary clotting factors during emergencies. Additionally, veterinarians may recommend avoiding procedures that could lead to bleeding and closely monitoring affected dogs for any signs of bleeding. In some cases, supportive care and medication may be employed to manage symptoms and improve the dog's quality of life.

基因检测的重要性

Genetic testing plays a crucial role in the management of afibrinogenaemia. By identifying carriers of the mutation, breeders can make informed decisions to minimize the risk of producing affected offspring. Early identification of at-risk dogs allows for proactive management strategies, improving outcomes for affected individuals and enhancing overall breed health.

结论

Afibrinogenaemia is a serious inherited bleeding disorder in dogs that requires careful management and awareness. Understanding the genetic basis, clinical signs, and treatment options is vital for pet owners and veterinarians alike. Through genetic testing and responsible breeding practices, the incidence of this condition can be reduced, promoting healthier futures for dogs at risk.

被认可参加测试的品种： 无纤维蛋白原血症 (AF)

• Austrian Standard Pinscher
• Brussels, Standard Griffon
• Miniature Longhaired Dachshund
• Miniature Smooth Dachshund
• Miniature Wirehaired Dachshund
• Serbian Balkan Standard Hound
• Standard Longhaired Dachshund
• Standard Wirehaired Dachshund

🧬 Interpretation of genotypes AF

❓ 了解有关基因型解释的更多信息

常见问题解答：理解解释

“清晰”是什么意思？

该动物不携带突变。就不会发展成这种疾病 并且不会将其传递下去。

“航母”是认真的吗？

不会。该动物通常是健康的，但可以将突变传播给它的 后代。

如果动物“受到影响”怎么办？

它携带两个突变的副本。预计临床症状取决于 这种疾病。它不应该被培育。

为什么男性/女性之间存在差异？

有些疾病与性别相关，因此其表现因性别而异 动物的性别。

预测后代

DNA 测试常见问题解答

这个 DNA 测试检测到什么？

This DNA test detects the mutation associated with Afibrinogenaemia in order to identify clear, carrier, or at-risk animals.

为什么要测试繁殖动物？

DNA 测试有助于饲养员计划更安全的交配并降低将突变传播给后代的风险。

这个测试的继承模式是什么？

该测试报告的遗传模式是常染色体隐性遗传。

此测试分析哪种突变？

This test analyses the mutation FGA c.1665delT.

携带动物是否必然受到影响？

未必。解释取决于遗传模式和产生的基因型。

参考

Mischke Reinhard, Metzger Julia, Distl Ottmar. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds. Genes (Basel). 2021 Jul 13;12(7):1065. doi: 10.3390/genes12071065.