狗 無纖維蛋白原血症 (AF)

依品種或臨床分類過濾 DNA 測試

Afibrinogenaemia in dogs is a rare but serious genetic disorder affecting blood clotting. A DNA test for afibrinogenaemia can help identify carriers and affected dogs, ensuring early diagnosis and management. Symptoms may include excessive bleeding, prolonged recovery from injuries, and spontaneous hemorrhages. By understanding the genetic basis of this condition, breeders can make informed decisions to prevent its occurrence in future litters. If you suspect your dog may have afibrinogenaemia, consult your veterinarian for testing options. Early intervention can significantly improve your dog's quality of life. Protect your furry friend by considering a DNA test today!

縮寫 ： AF

分析突變： FGA c.1665delT

繼承： 體染色體隱性遺傳

可從包裝中取得： Basic

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Understanding Afibrinogenaemia in Dogs

Afibrinogenaemia is a rare genetic disorder characterized by the absence of fibrinogen, a crucial protein involved in the blood coagulation process. This condition can lead to severe bleeding episodes, making it a significant health concern for affected dogs. The lack of fibrinogen impairs the body's ability to form blood clots, which is essential for stopping bleeding following an injury or during surgical procedures.

Genetic Basis of Afibrinogenaemia

The condition is caused by mutations in the FGA gene, which is responsible for producing fibrinogen. These mutations can lead to a complete absence of fibrinogen in the blood, resulting in the clinical manifestation of afibrinogenaemia. The genetic nature of this disorder means that it can be inherited, and identifying carriers of the mutation is crucial for breeding decisions to prevent the propagation of this trait.

臨床徵兆和症狀

Dogs with afibrinogenaemia may present with various clinical signs, primarily related to bleeding. Common symptoms include spontaneous bruising, prolonged bleeding from minor wounds, and excessive bleeding during or after surgical procedures. Some dogs may also experience internal bleeding, which can manifest as weakness, lethargy, or an increased heart rate. It's essential for pet owners to recognize these signs and seek veterinary attention promptly.

Diagnosis of Afibrinogenaemia

Diagnosis typically involves a combination of clinical evaluation and laboratory tests. Blood tests can reveal low or absent levels of fibrinogen, and additional coagulation studies may be performed to assess the overall clotting ability of the blood. In some cases, a DNA test can confirm the presence of mutations associated with afibrinogenaemia, providing a definitive diagnosis.

管理和治療方案

While there is no cure for afibrinogenaemia, management focuses on preventing and controlling bleeding episodes. This may include the use of blood transfusions to provide necessary clotting factors during emergencies. Additionally, veterinarians may recommend avoiding procedures that could lead to bleeding and closely monitoring affected dogs for any signs of bleeding. In some cases, supportive care and medication may be employed to manage symptoms and improve the dog's quality of life.

基因檢測的重要性

Genetic testing plays a crucial role in the management of afibrinogenaemia. By identifying carriers of the mutation, breeders can make informed decisions to minimize the risk of producing affected offspring. Early identification of at-risk dogs allows for proactive management strategies, improving outcomes for affected individuals and enhancing overall breed health.

結論

Afibrinogenaemia is a serious inherited bleeding disorder in dogs that requires careful management and awareness. Understanding the genetic basis, clinical signs, and treatment options is vital for pet owners and veterinarians alike. Through genetic testing and responsible breeding practices, the incidence of this condition can be reduced, promoting healthier futures for dogs at risk.

被認可參加測試的品種： 無纖維蛋白原血症 (AF)

• Austrian Standard Pinscher
• Brussels, Standard Griffon
• Miniature Longhaired Dachshund
• Miniature Smooth Dachshund
• Miniature Wirehaired Dachshund
• Serbian Balkan Standard Hound
• Standard Longhaired Dachshund
• Standard Wirehaired Dachshund

🧬 Interpretation of genotypes AF

❓ 了解有關基因型解釋的更多信息

常見問題：理解解釋

「清晰」是什麼意思？

該動物不攜帶突變。就不會發展成這種疾病 並且不會傳遞下去。

「航母」是認真的嗎？

不會。該動物通常是健康的，但可以將突變傳播給它的 後代。

如果動物「受到影響」怎麼辦？

它攜帶兩個突變的副本。預計臨床症狀取決於 這種疾病。它不應該被培育。

為什麼男性/女性之間會有差異？

有些疾病與性別有關，因此其表現因性別而異 動物的性別。

預測後代

DNA 測試常見問題解答

這個 DNA 測試檢測到什麼？

This DNA test detects the mutation associated with Afibrinogenaemia in order to identify clear, carrier, or at-risk animals.

為什麼要測試繁殖動物？

DNA 測試有助於飼養員計劃更安全的交配並降低將突變傳播給後代的風險。

這個測試的​​繼承模式是什麼？

此測試報告的遺傳模式是體染色體隱性遺傳。

此測試分析哪一種突變？

This test analyses the mutation FGA c.1665delT.

攜帶動物是否必然受到影響？

未必。解釋取決於遺傳模式和產生的基因型。

參考

Mischke Reinhard, Metzger Julia, Distl Ottmar. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds. Genes (Basel). 2021 Jul 13;12(7):1065. doi: 10.3390/genes12071065.