狗 非纖維蛋白原血症（ AF ）

按品種或臨床分類過濾 DNA 測試

Afibrinogenaemia in dogs is a rare but serious genetic disorder affecting blood clotting. A DNA test for afibrinogenaemia can help identify carriers and affected dogs, ensuring early diagnosis and management. Symptoms may include excessive bleeding, prolonged recovery from injuries, and spontaneous hemorrhages. By understanding the genetic basis of this condition, breeders can make informed decisions to prevent its occurrence in future litters. If you suspect your dog may have afibrinogenaemia, consult your veterinarian for testing options. Early intervention can significantly improve your dog's quality of life. Protect your furry friend by considering a DNA test today!

縮寫： AF

分析咗嘅突變： FGA c.1665delT

遺產 ： 常染色體隱性

喺包裝入面有得買： Basic

呢個 DNA 測試由我哋嘅包裝開始包括喺入面 Basic — 而且亦都係包嘅一部分 Basic, Standard, Advanced, Complete。

查看 DNA 檢測包 →

揀最適合你嘅動物嘅繁殖或者健康策略嘅群體。

Understanding Afibrinogenaemia in Dogs

Afibrinogenaemia is a rare genetic disorder characterized by the absence of fibrinogen, a crucial protein involved in the blood coagulation process. This condition can lead to severe bleeding episodes, making it a significant health concern for affected dogs. The lack of fibrinogen impairs the body's ability to form blood clots, which is essential for stopping bleeding following an injury or during surgical procedures.

Genetic Basis of Afibrinogenaemia

The condition is caused by mutations in the FGA gene, which is responsible for producing fibrinogen. These mutations can lead to a complete absence of fibrinogen in the blood, resulting in the clinical manifestation of afibrinogenaemia. The genetic nature of this disorder means that it can be inherited, and identifying carriers of the mutation is crucial for breeding decisions to prevent the propagation of this trait.

臨床徵兆同症狀

Dogs with afibrinogenaemia may present with various clinical signs, primarily related to bleeding. Common symptoms include spontaneous bruising, prolonged bleeding from minor wounds, and excessive bleeding during or after surgical procedures. Some dogs may also experience internal bleeding, which can manifest as weakness, lethargy, or an increased heart rate. It's essential for pet owners to recognize these signs and seek veterinary attention promptly.

Diagnosis of Afibrinogenaemia

Diagnosis typically involves a combination of clinical evaluation and laboratory tests. Blood tests can reveal low or absent levels of fibrinogen, and additional coagulation studies may be performed to assess the overall clotting ability of the blood. In some cases, a DNA test can confirm the presence of mutations associated with afibrinogenaemia, providing a definitive diagnosis.

管理同治療選項

While there is no cure for afibrinogenaemia, management focuses on preventing and controlling bleeding episodes. This may include the use of blood transfusions to provide necessary clotting factors during emergencies. Additionally, veterinarians may recommend avoiding procedures that could lead to bleeding and closely monitoring affected dogs for any signs of bleeding. In some cases, supportive care and medication may be employed to manage symptoms and improve the dog's quality of life.

遺傳檢測嘅重要性

Genetic testing plays a crucial role in the management of afibrinogenaemia. By identifying carriers of the mutation, breeders can make informed decisions to minimize the risk of producing affected offspring. Early identification of at-risk dogs allows for proactive management strategies, improving outcomes for affected individuals and enhancing overall breed health.

結論

Afibrinogenaemia is a serious inherited bleeding disorder in dogs that requires careful management and awareness. Understanding the genetic basis, clinical signs, and treatment options is vital for pet owners and veterinarians alike. Through genetic testing and responsible breeding practices, the incidence of this condition can be reduced, promoting healthier futures for dogs at risk.

測試認可嘅品種： 非纖維蛋白原血症（ AF ）

• Austrian Standard Pinscher
• Brussels, Standard Griffon
• Miniature Longhaired Dachshund
• Miniature Smooth Dachshund
• Miniature Wirehaired Dachshund
• Serbian Balkan Standard Hound
• Standard Longhaired Dachshund
• Standard Wirehaired Dachshund

🧬 Interpretation of genotypes AF

❓ 進一步了解基因型嘅解釋

常見問題：理解解釋

「清晰」係咩意思？

呢隻動物唔會攜帶呢個突變。佢唔會發病 同埋唔會傳落去。

「承載者」係咪認真？

唔係。隻動物一般都係健康嘅，但係可以將突變傳染畀佢 後代。

如果一隻動物係「受影響」嘅話點算好？

佢有兩個突變嘅副本。預計會有臨床症狀，視乎情況而定 個病。唔應該繁殖。

點解男 / 女有分別？

有啲疾病係同性別有關，所以佢哋嘅表現會因疾病而異 動物嘅性別。

預測後代

DNA 測試常見問題

呢個 DNA 測試可以檢測到啲咩？

This DNA test detects the mutation associated with Afibrinogenaemia in order to identify clear, carrier, or at-risk animals.

點解要測試一隻繁殖動物？

DNA 檢測有助養殖者計劃更安全嘅交配，同埋減低將突變傳播畀後代嘅風險。

呢個測試嘅繼承模式係點？

呢個測試報告嘅遺傳模式係常染色體隱性。

呢個測試會分析邊個突變？

This test analyses the mutation FGA c.1665delT.

載體動物係咪一定會受到影響？

唔一定。解釋取決於遺傳模式同所產生嘅基因型。

參考文獻

Mischke Reinhard, Metzger Julia, Distl Ottmar. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds. Genes (Basel). 2021 Jul 13;12(7):1065. doi: 10.3390/genes12071065.