Ce înseamnă „Clear”?
Animalul nu poartă mutația. Nu va dezvolta boala și nu o va transmite mai departe.
Câine Tulburarea congenitală a mișcării oglinzii la Weimaraner (CMM1)
The DNA test for Congenital Mirror Movement Disorder in Weimaraners (CMM1) is essential for responsible breeders and owners. CMM1 is a genetic condition causing involuntary mirrored movements, affecting a dog’s coordination and quality of life. Early detection through this DNA test helps identify carriers and affected dogs, preventing the spread of the disorder in breeding lines. By using the CMM1 DNA test, breeders can make informed decisions to promote healthier Weimaraner litters. This test is simple, accurate, and widely available through specialized veterinary genetic labs. Ensuring your Weimaraner is tested supports better health and wellbeing. Prioritize genetic testing for CMM1 to maintain strong, active, and happy dogs.
Abreviere: CMM1
Mutația analizată: EFNB3 c.643_644dup
Moștenire: Autosomal recesiv
Acronim
CMM1
Frecvența observată
Severitate clinică
Clasificare clinică
Boli neurologice
Mutație analizată
EFNB3 c.643_644dup
Modul de moștenire
Autosomal recesiv (Complet)
Rezumatul testului:
Congenital Mirror Movement Disorder (CMM1) in Weimaraners is a genetic condition that causes involuntary mirrored movements of the limbs. This disorder is inherited and can be identified through a specific DNA test. Early detection via genetic testing helps breeders avoid passing the condition to offspring. Understanding CMM1 is crucial for maintaining the health and mobility of affected dogs. Responsible breeding practices rely on DNA testing to reduce the prevalence of this disorder in the Weimaraner population.
Disponibil din pachet: Basic
Acest test ADN este inclus începând din pachetul nostru Basic — și face parte și din pachete Basic, Standard, Advanced, Complete.
Vizualizați pachetele de teste ADN →Alege haita care se potrivește cel mai bine cu strategia ta de creștere sau de sănătate a animalelor tale.
Understanding Congenital Mirror Movement Disorder in Weimaraners
Congenital Mirror Movement Disorder (CMM1) is a neurological condition that affects the motor coordination of dogs, particularly in Weimaraners. This hereditary disorder is characterized by involuntary mirror movements, where the affected dog exhibits simultaneous movements on both sides of its body. For example, if the dog raises its right paw, the left paw may also lift involuntarily, leading to challenges in performing coordinated tasks.
Symptoms of CMM1
Dogs suffering from CMM1 typically display a range of symptoms that can be observed from an early age. Common signs include clumsiness, difficulty in performing tasks that require precise movements, and exaggerated movements on one side of the body that are mirrored on the other side. These symptoms can affect the dog's ability to run, play, and engage in activities that require agility and coordination.
Genetic Basis of Congenital Mirror Movement Disorder
CMM1 is caused by a genetic mutation that affects the development of the nervous system. This mutation disrupts normal motor control pathways, resulting in the characteristic involuntary movements. Understanding the genetic basis of this condition is crucial for breeders and owners as it allows for better management and potential avoidance of breeding affected individuals, thereby reducing the prevalence of the disorder in future generations.
Diagnosis and Management
Diagnosis of CMM1 typically involves a combination of clinical observation and genetic testing. While there is no cure for the disorder, management strategies can help improve the quality of life for affected dogs. These may include physical therapy to enhance coordination and strength, as well as training techniques that focus on encouraging voluntary movements. Supportive care is essential to help these dogs adapt to their condition.
Importanța testării ADN
DNA testing for CMM1 plays a critical role in identifying carriers and affected individuals. By conducting genetic tests, breeders can make informed decisions about their breeding programs, aiming to reduce the incidence of this disorder. Responsible breeding practices, guided by DNA test results, contribute to healthier populations of Weimaraners and can prevent the transmission of CMM1 to future generations.
Rasa recunoscută pentru test: Tulburarea congenitală a mișcării oglinzii la Weimaraner (CMM1)
- Weimaraner
🧬 Interpretation of genotypes CMM1
Genotip
Stare
🟡 N/N
Non-transportator - Fără risc
🟡 N/CMM1
Transportator - Fără risc
❌ CMM1/CMM1
Afectat - În pericol
Întrebări frecvente: înțelegerea interpretării
Un „Carrier” este serios?
Nu. Animalul este în general sănătos, dar poate transmite mutația acestuia urmas.
Ce se întâmplă dacă un animal este „Afectat”?
Are două copii mutante. Se așteaptă semne clinice în funcție de boala. Nu trebuie crescut.
De ce există diferențe între bărbat/femeie?
Unele boli sunt legate de sex, astfel încât expresia lor variază în funcție de sexul animalului.
Prezice descendenții
N/N (netransportator)
N/CMM1 (Purtător)
CMM1/CMM1 (Afectat)
Întrebări frecvente despre testul ADN
Ce detectează acest test ADN?
This DNA test detects the mutation associated with Congenital Mirror Movement Disorder in Weimaraners (CMM1) in order to identify clear, carrier, or at-risk animals.
De ce testați un animal de reproducție?
Testarea ADN îi ajută pe crescători să planifice împerecheri mai sigure și să reducă riscul de transmitere a mutației către descendenți.
Care este modul de moștenire al acestui test?
Modul de moștenire raportat pentru acest test este autosomal recesiv.
Ce mutație este analizată în acest test?
This test analyses the mutation EFNB3 c.643_644dup.
Este neapărat afectat un animal purtător?
Nu neapărat. Interpretarea depinde de modelul de moștenire și de genotipul rezultat.
Referințe
Schwarz, C., Bartenschlager, F., Kershaw, O., Braun, J., Guevar, J., Jagannathan, V., Epplen, J.T., Reineking, W., Baumgärtner, W., Bhatia, K.P., Gruber, A.D., Leeb, T. : EFNB3 frameshift variant in Weimaraner dogs with a condition resembling a congenital mirror movement disorder. Mov Disord 40:1883-1891, 2025. Pubmed reference: 40401490