Dog Congenital Mirror Movement Disorder in Weimaraners (CMM1)

The DNA test for Congenital Mirror Movement Disorder in Weimaraners (CMM1) is essential for responsible breeders and owners. CMM1 is a genetic condition causing involuntary mirrored movements, affecting a dog’s coordination and quality of life. Early detection through this DNA test helps identify carriers and affected dogs, preventing the spread of the disorder in breeding lines. By using the CMM1 DNA test, breeders can make informed decisions to promote healthier Weimaraner litters. This test is simple, accurate, and widely available through specialized veterinary genetic labs. Ensuring your Weimaraner is tested supports better health and wellbeing. Prioritize genetic testing for CMM1 to maintain strong, active, and happy dogs.

Abbreviation : CMM1

Analysed mutation : EFNB3 c.643_644dup

Inheritance : Autosomal Recessive

Acronym

CMM1

Observed frequency

Rare

Clinical severity

Moderate

Clinical classification

Neurological Diseases

Analysed mutation

EFNB3 c.643_644dup

Mode of inheritance

Autosomal Recessive (Complete)

Test summary:

Congenital Mirror Movement Disorder (CMM1) in Weimaraners is a genetic condition that causes involuntary mirrored movements of the limbs. This disorder is inherited and can be identified through a specific DNA test. Early detection via genetic testing helps breeders avoid passing the condition to offspring. Understanding CMM1 is crucial for maintaining the health and mobility of affected dogs. Responsible breeding practices rely on DNA testing to reduce the prevalence of this disorder in the Weimaraner population.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Choose the pack that best fits your breeding or health strategy of your animals.

Understanding Congenital Mirror Movement Disorder in Weimaraners

Congenital Mirror Movement Disorder (CMM1) is a neurological condition that affects the motor coordination of dogs, particularly in Weimaraners. This hereditary disorder is characterized by involuntary mirror movements, where the affected dog exhibits simultaneous movements on both sides of its body. For example, if the dog raises its right paw, the left paw may also lift involuntarily, leading to challenges in performing coordinated tasks.

Symptoms of CMM1

Dogs suffering from CMM1 typically display a range of symptoms that can be observed from an early age. Common signs include clumsiness, difficulty in performing tasks that require precise movements, and exaggerated movements on one side of the body that are mirrored on the other side. These symptoms can affect the dog's ability to run, play, and engage in activities that require agility and coordination.

Genetic Basis of Congenital Mirror Movement Disorder

CMM1 is caused by a genetic mutation that affects the development of the nervous system. This mutation disrupts normal motor control pathways, resulting in the characteristic involuntary movements. Understanding the genetic basis of this condition is crucial for breeders and owners as it allows for better management and potential avoidance of breeding affected individuals, thereby reducing the prevalence of the disorder in future generations.

Diagnosis and Management

Diagnosis of CMM1 typically involves a combination of clinical observation and genetic testing. While there is no cure for the disorder, management strategies can help improve the quality of life for affected dogs. These may include physical therapy to enhance coordination and strength, as well as training techniques that focus on encouraging voluntary movements. Supportive care is essential to help these dogs adapt to their condition.

Importance of DNA Testing

DNA testing for CMM1 plays a critical role in identifying carriers and affected individuals. By conducting genetic tests, breeders can make informed decisions about their breeding programs, aiming to reduce the incidence of this disorder. Responsible breeding practices, guided by DNA test results, contribute to healthier populations of Weimaraners and can prevent the transmission of CMM1 to future generations.

Breed recognized for the test : Congenital Mirror Movement Disorder in Weimaraners (CMM1)

Weimaraner

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes CMM1

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/CMM1

Carrier - No Risk

❌ CMM1/CMM1

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/CMM1 (Carrier)

CMM1/CMM1 (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Congenital Mirror Movement Disorder in Weimaraners (CMM1) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation EFNB3 c.643_644dup.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Schwarz, C., Bartenschlager, F., Kershaw, O., Braun, J., Guevar, J., Jagannathan, V., Epplen, J.T., Reineking, W., Baumgärtner, W., Bhatia, K.P., Gruber, A.D., Leeb, T. : EFNB3 frameshift variant in Weimaraner dogs with a condition resembling a congenital mirror movement disorder. Mov Disord 40:1883-1891, 2025. Pubmed reference: 40401490

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