O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Transtorno congênito do movimento do espelho em Weimaraners (CMM1)
The DNA test for Congenital Mirror Movement Disorder in Weimaraners (CMM1) is essential for responsible breeders and owners. CMM1 is a genetic condition causing involuntary mirrored movements, affecting a dog’s coordination and quality of life. Early detection through this DNA test helps identify carriers and affected dogs, preventing the spread of the disorder in breeding lines. By using the CMM1 DNA test, breeders can make informed decisions to promote healthier Weimaraner litters. This test is simple, accurate, and widely available through specialized veterinary genetic labs. Ensuring your Weimaraner is tested supports better health and wellbeing. Prioritize genetic testing for CMM1 to maintain strong, active, and happy dogs.
Abreviatura: CMM1
Mutação analisada: EFNB3 c.643_644dup
Herança: Autossômico Recessivo
Acrônimo
CMM1
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Neurológicas
Mutação analisada
EFNB3 c.643_644dup
Modo de herança
Autossômico Recessivo (Completo)
Resumo do teste:
Congenital Mirror Movement Disorder (CMM1) in Weimaraners is a genetic condition that causes involuntary mirrored movements of the limbs. This disorder is inherited and can be identified through a specific DNA test. Early detection via genetic testing helps breeders avoid passing the condition to offspring. Understanding CMM1 is crucial for maintaining the health and mobility of affected dogs. Responsible breeding practices rely on DNA testing to reduce the prevalence of this disorder in the Weimaraner population.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Congenital Mirror Movement Disorder in Weimaraners
Congenital Mirror Movement Disorder (CMM1) is a neurological condition that affects the motor coordination of dogs, particularly in Weimaraners. This hereditary disorder is characterized by involuntary mirror movements, where the affected dog exhibits simultaneous movements on both sides of its body. For example, if the dog raises its right paw, the left paw may also lift involuntarily, leading to challenges in performing coordinated tasks.
Symptoms of CMM1
Dogs suffering from CMM1 typically display a range of symptoms that can be observed from an early age. Common signs include clumsiness, difficulty in performing tasks that require precise movements, and exaggerated movements on one side of the body that are mirrored on the other side. These symptoms can affect the dog's ability to run, play, and engage in activities that require agility and coordination.
Genetic Basis of Congenital Mirror Movement Disorder
CMM1 is caused by a genetic mutation that affects the development of the nervous system. This mutation disrupts normal motor control pathways, resulting in the characteristic involuntary movements. Understanding the genetic basis of this condition is crucial for breeders and owners as it allows for better management and potential avoidance of breeding affected individuals, thereby reducing the prevalence of the disorder in future generations.
Diagnosis and Management
Diagnosis of CMM1 typically involves a combination of clinical observation and genetic testing. While there is no cure for the disorder, management strategies can help improve the quality of life for affected dogs. These may include physical therapy to enhance coordination and strength, as well as training techniques that focus on encouraging voluntary movements. Supportive care is essential to help these dogs adapt to their condition.
Importância dos testes de DNA
DNA testing for CMM1 plays a critical role in identifying carriers and affected individuals. By conducting genetic tests, breeders can make informed decisions about their breeding programs, aiming to reduce the incidence of this disorder. Responsible breeding practices, guided by DNA test results, contribute to healthier populations of Weimaraners and can prevent the transmission of CMM1 to future generations.
Raça reconhecida para o teste: Transtorno congênito do movimento do espelho em Weimaraners (CMM1)
- Weimaraner
🧬 Interpretation of genotypes CMM1
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/CMM1
Transportadora - Sem Risco
❌ CMM1/CMM1
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/CMM1 (Operadora)
CMM1/CMM1 (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Congenital Mirror Movement Disorder in Weimaraners (CMM1) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation EFNB3 c.643_644dup.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Schwarz, C., Bartenschlager, F., Kershaw, O., Braun, J., Guevar, J., Jagannathan, V., Epplen, J.T., Reineking, W., Baumgärtner, W., Bhatia, K.P., Gruber, A.D., Leeb, T. : EFNB3 frameshift variant in Weimaraner dogs with a condition resembling a congenital mirror movement disorder. Mov Disord 40:1883-1891, 2025. Pubmed reference: 40401490