Hvad betyder "Ryd"?
Dyret bærer ikke mutationen. Det vil ikke udvikle sygdommen og vil ikke give det videre.
Hund Medfødt spejlbevægelsesforstyrrelse hos Weimaranere (CMM1)
The DNA test for Congenital Mirror Movement Disorder in Weimaraners (CMM1) is essential for responsible breeders and owners. CMM1 is a genetic condition causing involuntary mirrored movements, affecting a dog’s coordination and quality of life. Early detection through this DNA test helps identify carriers and affected dogs, preventing the spread of the disorder in breeding lines. By using the CMM1 DNA test, breeders can make informed decisions to promote healthier Weimaraner litters. This test is simple, accurate, and widely available through specialized veterinary genetic labs. Ensuring your Weimaraner is tested supports better health and wellbeing. Prioritize genetic testing for CMM1 to maintain strong, active, and happy dogs.
Forkortelse: CMM1
Analyseret mutation: EFNB3 c.643_644dup
Arv: Autosomal recessiv
Akronym
CMM1
Observeret frekvens
Klinisk sværhedsgrad
Klinisk klassificering
Neurologiske sygdomme
Analyseret mutation
EFNB3 c.643_644dup
Arvemåde
Autosomal recessiv (Complete)
Testresumé:
Congenital Mirror Movement Disorder (CMM1) in Weimaraners is a genetic condition that causes involuntary mirrored movements of the limbs. This disorder is inherited and can be identified through a specific DNA test. Early detection via genetic testing helps breeders avoid passing the condition to offspring. Understanding CMM1 is crucial for maintaining the health and mobility of affected dogs. Responsible breeding practices rely on DNA testing to reduce the prevalence of this disorder in the Weimaraner population.
Tilgængelig fra pakken: Basic
Denne DNA-test er inkluderet fra vores pakke Basic — og er også en del af pakkerne Basic, Standard, Advanced, Complete.
Se DNA-testpakker →Vælg den flok, der passer bedst til din avls- eller sundhedsstrategi for dine dyr.
Understanding Congenital Mirror Movement Disorder in Weimaraners
Congenital Mirror Movement Disorder (CMM1) is a neurological condition that affects the motor coordination of dogs, particularly in Weimaraners. This hereditary disorder is characterized by involuntary mirror movements, where the affected dog exhibits simultaneous movements on both sides of its body. For example, if the dog raises its right paw, the left paw may also lift involuntarily, leading to challenges in performing coordinated tasks.
Symptoms of CMM1
Dogs suffering from CMM1 typically display a range of symptoms that can be observed from an early age. Common signs include clumsiness, difficulty in performing tasks that require precise movements, and exaggerated movements on one side of the body that are mirrored on the other side. These symptoms can affect the dog's ability to run, play, and engage in activities that require agility and coordination.
Genetic Basis of Congenital Mirror Movement Disorder
CMM1 is caused by a genetic mutation that affects the development of the nervous system. This mutation disrupts normal motor control pathways, resulting in the characteristic involuntary movements. Understanding the genetic basis of this condition is crucial for breeders and owners as it allows for better management and potential avoidance of breeding affected individuals, thereby reducing the prevalence of the disorder in future generations.
Diagnosis and Management
Diagnosis of CMM1 typically involves a combination of clinical observation and genetic testing. While there is no cure for the disorder, management strategies can help improve the quality of life for affected dogs. These may include physical therapy to enhance coordination and strength, as well as training techniques that focus on encouraging voluntary movements. Supportive care is essential to help these dogs adapt to their condition.
Vigtigheden af DNA-testning
DNA testing for CMM1 plays a critical role in identifying carriers and affected individuals. By conducting genetic tests, breeders can make informed decisions about their breeding programs, aiming to reduce the incidence of this disorder. Responsible breeding practices, guided by DNA test results, contribute to healthier populations of Weimaraners and can prevent the transmission of CMM1 to future generations.
Racen anerkendt til testen: Medfødt spejlbevægelsesforstyrrelse hos Weimaranere (CMM1)
- Weimaraner
🧬 Interpretation of genotypes CMM1
Genotype
Status
🟡 N/N
Ikke-transportør - Ingen risiko
🟡 N/CMM1
Transportør - Ingen risiko
❌ CMM1/CMM1
Berørt - i fare
FAQ: forstå fortolkningen
Er en "Carrier" seriøs?
Nej. Dyret er generelt sundt, men kan overføre mutationen til dens afkom.
Hvad hvis et dyr er "påvirket"?
Den bærer to muterede kopier. Kliniske tegn forventes afhængig af sygdommen. Det skal ikke avles.
Hvorfor er der forskel på mand/kvinde?
Nogle sygdomme er kønsbundne, så deres udtryk varierer afhængigt af dyrs køn.
Forudsig afkom
N/N (ikke-transportor)
N/CMM1 (Transportør)
CMM1/CMM1 (Påvirket)
Ofte stillede spørgsmål om DNA-test
Hvad opdager denne DNA-test?
This DNA test detects the mutation associated with Congenital Mirror Movement Disorder in Weimaraners (CMM1) in order to identify clear, carrier, or at-risk animals.
Hvorfor teste et avlsdyr?
DNA-test hjælper opdrættere med at planlægge sikrere parringer og reducerer risikoen for at overføre mutationen til afkom.
Hvad er arvemetoden for denne test?
Den nedarvede tilstand, der er rapporteret for denne test, er autosomal recessiv.
Hvilken mutation analyseres i denne test?
This test analyses the mutation EFNB3 c.643_644dup.
Er et bærende dyr nødvendigvis påvirket?
Ikke nødvendigvis. Fortolkningen afhænger af arvemønsteret og den resulterende genotype.
Referencer
Schwarz, C., Bartenschlager, F., Kershaw, O., Braun, J., Guevar, J., Jagannathan, V., Epplen, J.T., Reineking, W., Baumgärtner, W., Bhatia, K.P., Gruber, A.D., Leeb, T. : EFNB3 frameshift variant in Weimaraner dogs with a condition resembling a congenital mirror movement disorder. Mov Disord 40:1883-1891, 2025. Pubmed reference: 40401490