Kaj pomeni »Počisti«?
Žival ne nosi mutacije. To ne bo razvilo bolezni in ga ne bo posredoval naprej.
pes Akromatopsija tipa 3 pri nemški kratkodlaki ptičarki (PRAcd)
The DNA test for Achromatopsia Type 3 (PRAcd) in German Shorthaired Pointers is essential for responsible breeding. This genetic screening identifies carriers of the PRAcd mutation, which causes progressive vision loss and color blindness in affected dogs. Early detection through DNA testing helps breeders prevent passing this hereditary condition to future generations. By using the PRAcd test, owners can ensure healthier litters and maintain the breed’s overall well-being. Regular testing supports informed breeding decisions and promotes the longevity of German Shorthaired Pointers. Protect your dog’s vision and contribute to breed health with the Achromatopsia Type 3 DNA test.
Okrajšava: PRAcd
Analizirana mutacija: CNGB3 c.784G>A
dedovanje: Avtosomno recesivno
akronim
PRAcd
Opazovana frekvenca
Klinična resnost
Klinična klasifikacija
Oftalmične bolezni
Analizirana mutacija
CNGB3 c.784G>A
p.(D262N)
p.(D262N)
Način dedovanja
Avtosomno recesivno
Povzetek testa:
The DNA test for Achromatopsia Type 3 (PRAcd) in German Shorthaired Pointers helps identify carriers and affected dogs. This inherited condition causes complete color blindness and vision problems. Early testing allows breeders to make informed decisions to reduce the risk of passing the disorder. By screening breeding dogs, the prevalence of PRAcd can be minimized in future generations. Responsible breeding ensures healthier dogs with better quality of life.
Na voljo iz paketa: Basic
Ta DNK test je vključen od našega paketa Basic — in je tudi del paketov Basic, Standard, Advanced, Complete.
Oglejte si pakete testov DNK →Izberite paket, ki najbolje ustreza vaši vzrejni ali zdravstveni strategiji vaših živali.
Understanding Achromatopsia Type 3 in German Shorthaired Pointers
Achromatopsia Type 3, also known as Progressive Retinal Atrophy with complete color blindness (PRAcd), is a hereditary condition that affects the vision of German Shorthaired Pointers. This genetic disorder results from mutations in specific genes that are crucial for the proper functioning of photoreceptor cells in the retina, leading to vision impairment over time.
Symptoms of Achromatopsia Type 3
Dogs affected by Achromatopsia Type 3 typically exhibit symptoms such as a lack of color vision, difficulty seeing in bright light, and potential night blindness. Owners may notice that their dogs have trouble navigating their environment, particularly in brightly lit areas, as their ability to perceive colors is significantly diminished.
Genetic Basis of the Condition
This condition is inherited in an autosomal recessive manner, meaning that both copies of the gene must be mutated for the dog to express the disease. Carriers, which have one normal and one mutated gene, do not show symptoms but can pass the condition to their offspring. Identifying carriers through DNA testing is essential for responsible breeding practices, as it helps prevent the propagation of the condition in future generations.
Impact on Quality of Life
While Achromatopsia Type 3 can lead to significant visual impairment, many dogs adapt well to their condition. Owners can assist by providing a safe environment and ensuring that their pets are comfortable in low-light conditions or areas with bright lighting. Understanding the limitations of their dog's vision allows owners to make necessary adjustments to enhance their pet's quality of life.
Management and Care
Managing a dog with Achromatopsia Type 3 primarily involves environmental modifications rather than medical interventions. Owners should ensure that their living space is free from obstacles that could pose a danger, as affected dogs may not respond to visual cues in the same way as their sighted counterparts. Regular veterinary check-ups are also advised to monitor the dog's overall eye health and address any other potential issues that may arise.
Zaključek
Achromatopsia Type 3 in German Shorthaired Pointers is a serious genetic condition that affects visual perception. Understanding the symptoms, genetic basis, and management strategies is crucial for owners and breeders alike. Through responsible breeding and proper care, the impact of this condition on affected dogs can be alleviated, allowing them to lead fulfilling lives despite their visual challenges.
Pasma, priznana za test: Akromatopsija tipa 3 pri nemški kratkodlaki ptičarki (PRAcd)
- German Shorthaired Pointer
🧬 Interpretation of genotypes PRAcd
Genotip
Stanje
🟡 N/N
Brez prevoznika – brez tveganja
🟡 N/PRAcd
Prevoznik - brez tveganja
❌ PRAcd/PRAcd
Prizadeti – ogroženi
Pogosta vprašanja: razumevanje interpretacije
Je "prevoznik" resen?
Ne. Žival je na splošno zdrava, vendar lahko prenese mutacijo na svojo potomci.
Kaj pa, če je žival "prizadeta"?
Nosi dve mutirani kopiji. Klinični znaki so pričakovani glede na bolezen. Ne sme se vzrejati.
Zakaj obstajajo razlike med moškim in žensko?
Nekatere bolezni so povezane s spolom, zato se njihov izraz razlikuje glede na spol živali.
Napoved potomcev
N/N (neprevoznik)
N/PRAcd (Nosilec)
PRAcd/PRAcd (Prizadeti)
Pogosta vprašanja o testu DNK
Kaj ugotovi ta DNK test?
This DNA test detects the mutation associated with Achromatopsia Type 3 In German Shorthaired Pointer (PRAcd) in order to identify clear, carrier, or at-risk animals.
Zakaj testirati plemensko žival?
Testiranje DNK pomaga rejcem pri načrtovanju varnejših parjenj in zmanjšanju tveganja prenosa mutacije na potomce.
Kakšen je način dedovanja tega testa?
Način dedovanja, poročan za ta test, je avtosomno recesivno.
Katero mutacijo analiziramo v tem testu?
This test analyses the mutation CNGB3 c.784G>A.
Ali je žival prenašalka nujno prizadeta?
Ni nujno. Razlaga je odvisna od vzorca dedovanja in nastalega genotipa.
Reference
Sidjanin Duska J, Lowe Jennifer K, McElwee John L, Milne Bruce S, Phippen Taryn M, Sargan David R, Aguirre Gustavo D, Acland Gregory M, Ostrander Elaine A. Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3. Hum Mol Genet. 2002 Aug 1;11(16):1823-33. doi: 10.1093/hmg/11.16.1823.