O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Acromatopsia tipo 3 em ponteiro alemão de pêlo curto (PRAcd)
The DNA test for Achromatopsia Type 3 (PRAcd) in German Shorthaired Pointers is essential for responsible breeding. This genetic screening identifies carriers of the PRAcd mutation, which causes progressive vision loss and color blindness in affected dogs. Early detection through DNA testing helps breeders prevent passing this hereditary condition to future generations. By using the PRAcd test, owners can ensure healthier litters and maintain the breed’s overall well-being. Regular testing supports informed breeding decisions and promotes the longevity of German Shorthaired Pointers. Protect your dog’s vision and contribute to breed health with the Achromatopsia Type 3 DNA test.
Abreviatura: PRAcd
Mutação analisada: CNGB3 c.784G>A
Herança: Autossômico Recessivo
Acrônimo
PRAcd
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Oftalmológicas
Mutação analisada
CNGB3 c.784G>A
p.(D262N)
p.(D262N)
Modo de herança
Autossômico Recessivo
Resumo do teste:
The DNA test for Achromatopsia Type 3 (PRAcd) in German Shorthaired Pointers helps identify carriers and affected dogs. This inherited condition causes complete color blindness and vision problems. Early testing allows breeders to make informed decisions to reduce the risk of passing the disorder. By screening breeding dogs, the prevalence of PRAcd can be minimized in future generations. Responsible breeding ensures healthier dogs with better quality of life.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Achromatopsia Type 3 in German Shorthaired Pointers
Achromatopsia Type 3, also known as Progressive Retinal Atrophy with complete color blindness (PRAcd), is a hereditary condition that affects the vision of German Shorthaired Pointers. This genetic disorder results from mutations in specific genes that are crucial for the proper functioning of photoreceptor cells in the retina, leading to vision impairment over time.
Symptoms of Achromatopsia Type 3
Dogs affected by Achromatopsia Type 3 typically exhibit symptoms such as a lack of color vision, difficulty seeing in bright light, and potential night blindness. Owners may notice that their dogs have trouble navigating their environment, particularly in brightly lit areas, as their ability to perceive colors is significantly diminished.
Genetic Basis of the Condition
This condition is inherited in an autosomal recessive manner, meaning that both copies of the gene must be mutated for the dog to express the disease. Carriers, which have one normal and one mutated gene, do not show symptoms but can pass the condition to their offspring. Identifying carriers through DNA testing is essential for responsible breeding practices, as it helps prevent the propagation of the condition in future generations.
Impact on Quality of Life
While Achromatopsia Type 3 can lead to significant visual impairment, many dogs adapt well to their condition. Owners can assist by providing a safe environment and ensuring that their pets are comfortable in low-light conditions or areas with bright lighting. Understanding the limitations of their dog's vision allows owners to make necessary adjustments to enhance their pet's quality of life.
Gestão e Cuidado
Managing a dog with Achromatopsia Type 3 primarily involves environmental modifications rather than medical interventions. Owners should ensure that their living space is free from obstacles that could pose a danger, as affected dogs may not respond to visual cues in the same way as their sighted counterparts. Regular veterinary check-ups are also advised to monitor the dog's overall eye health and address any other potential issues that may arise.
Conclusão
Achromatopsia Type 3 in German Shorthaired Pointers is a serious genetic condition that affects visual perception. Understanding the symptoms, genetic basis, and management strategies is crucial for owners and breeders alike. Through responsible breeding and proper care, the impact of this condition on affected dogs can be alleviated, allowing them to lead fulfilling lives despite their visual challenges.
Raça reconhecida para o teste: Acromatopsia tipo 3 em ponteiro alemão de pêlo curto (PRAcd)
- German Shorthaired Pointer
🧬 Interpretation of genotypes PRAcd
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/PRAcd
Transportadora - Sem Risco
❌ PRAcd/PRAcd
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/PRAcd (Operadora)
PRAcd/PRAcd (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Achromatopsia Type 3 In German Shorthaired Pointer (PRAcd) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation CNGB3 c.784G>A.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Sidjanin Duska J, Lowe Jennifer K, McElwee John L, Milne Bruce S, Phippen Taryn M, Sargan David R, Aguirre Gustavo D, Acland Gregory M, Ostrander Elaine A. Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3. Hum Mol Genet. 2002 Aug 1;11(16):1823-33. doi: 10.1093/hmg/11.16.1823.