Kiko “Kla” ta nifiká?
E animal no ta karga e mutashon. E no lo desaroyá e malesa i lo no pasa esaki.
Kachó Síndrome di Neutrofil Atrapá (TNS)
Discover your dog's genetic health with our Trapped Neutrophil Syndrome (TNS) DNA test. This critical test identifies dogs at risk of TNS, a severe immune disorder preventing effective infection fighting. Early detection allows for proactive health management, reducing the risk of serious infections. Our test offers quick, reliable results, guiding your dog's care. Protect your beloved pet from hidden health issues with our expertly designed TNS DNA test.
Abreviashon : TNS
Mutashon analisá : VPS13B c.2893_2896del
Herensha : Autosomal Resesivo
Sigla
TNS
Frekuensha opservá
Severidat klíniko
Klasifikashon klíniko
Malesanan Imunologiko
Mutashon analisá
VPS13B c.2893_2896del
p.(V595Ifs)
p.(V595Ifs)
Modo di herensia
Autosomal Resesivo
Resumen di prueba:
Trapped Neutrophil Syndrome (TNS) is a genetic disorder affecting dogs' immune systems, leading to severe infections. This condition prevents neutrophils from reaching infection sites, making affected dogs prone to illnesses. Early detection through DNA testing can be life-saving. Knowing your dog's TNS status helps in managing their health proactively. Ensure your canine companion's wellbeing with our comprehensive TNS DNA test.
Obtenibel for di e pakete : Basic
E tèst di DNA aki ta inkluí kuminsando for di nos pakete Basic — i tambe ta parti di e paketenan Basic, Standard, Advanced, Complete.
Wak e paketenan di tèst di DNA →Skohe e pakete ku ta pas mihó ku bo strategia di krio òf salú di bo bestianan.
Understanding Trapped Neutrophil Syndrome (TNS)
Trapped Neutrophil Syndrome (TNS) is a rare genetic disorder that affects the immune system of dogs. This condition is characterized by the inability of neutrophils, a type of white blood cell, to migrate from the bone marrow to the bloodstream and tissues where they are needed to fight infections. As a result, affected dogs may have a reduced number of functional neutrophils circulating in their blood, leading to an increased susceptibility to infections.
Symptoms of Trapped Neutrophil Syndrome
Dogs with Trapped Neutrophil Syndrome may exhibit a range of symptoms, including recurrent infections, poor wound healing, and overall lethargy. These infections can manifest as skin infections, respiratory issues, or gastrointestinal problems. Additionally, the affected dogs may show signs of fever, weight loss, and diminished appetite due to their compromised immune system.
Genetic Basis of TNS
TNS is caused by mutations in specific genes that are essential for the normal development and function of neutrophils. These genetic mutations interfere with the cellular processes required for neutrophil maturation and release. Understanding the genetic basis of TNS is crucial for diagnosing the condition and developing potential treatment strategies.
Diagnosis of TNS
Diagnosis of Trapped Neutrophil Syndrome can be challenging and often involves a combination of clinical evaluation and laboratory testing. Veterinarians may perform blood tests to assess the neutrophil count and functionality, as well as genetic testing to identify specific mutations associated with TNS. Early diagnosis is vital to manage the condition effectively and prevent severe complications.
Treatment Options for TNS
While there is no definitive cure for Trapped Neutrophil Syndrome, treatment focuses on managing symptoms and preventing infections. This may include the use of antibiotics to treat existing infections, supportive care to maintain overall health, and regular monitoring by a veterinarian. In some cases, immunomodulatory therapies may be considered to enhance the immune response.
Pronóstiko i Maneho
The prognosis for dogs with Trapped Neutrophil Syndrome varies depending on the severity of the condition and the effectiveness of management strategies. With appropriate care and monitoring, some dogs can lead relatively normal lives. However, ongoing veterinary support is essential to adapt treatment plans as needed and to address any emerging health issues promptly.
Rasa rekonosé pa e tèst: Síndrome di Neutrofil Atrapá (TNS)
- Australian Koolie
- Bearded Collie
- Border Collie
- Bordoodle
- Farm Collie
- Koolie
- Old Farm Collie
- Rough Collie
- Scottish Collie
- Scottish Rough Collie
- Scottish Smooth Collie
- Smooth Collie
- Working Kelpie
🧬 Interpretation of genotypes TNS
Genotipo
Estado
🟡 N/N
No-transportador - Sin Riesgo
🟡 N/TNS
Transportadó - Sin Riesgo
❌ TNS/TNS
Afektá - Na Riesgo
FAQ: komprondementu di e interpretashon
Un “Transportadó” ta serio?
No. E animal ta generalmente salú pero por transmití e mutashon na su yu.
Kiko si un bestia ta “Afektá”?
E ta karga dos kopia mutá. Ta spera señalnan klíniko dependiendo di e malesa. E no mester wòrdu kriá.
Dikon tin diferensia entre hòmber/muhé?
Algun malesa ta mará na sekso, pues nan ekspreshon ta varia dependiendo di e sekso di bestia.
Pronostiká Desendiente
N/N (no-transportador) )
N/TNS (Transportador) )
TNS/TNS (Afektá) )
FAQ di Prueba di DNA
Kiko e tèst di DNA aki ta detektá?
This DNA test detects the mutation associated with Trapped Neutrophil Syndrome (TNS) in order to identify clear, carrier, or at-risk animals.
Dikon tèst un bestia di krio?
Prueba di DNA ta yuda kriadónan plania parehamentu mas sigur i redusí e riesgo di transmití e mutashon na yunan.
Kiko ta e moda di herensia di e tèst aki?
E moda di herensia raportá pa e tèst aki ta Outosomal Resesivo.
Kua mutashon ta wòrdu analisá den e tèst aki?
This test analyses the mutation VPS13B c.2893_2896del.
Un bestia kargadó ta nesesariamente afektá?
No nesesariamente. Interpretashon ta dependé di e patronchi di herensia i e genotipo resultante.
Referensianan
Shearman Jeremy R, Wilton Alan N. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics. 2011 May 23;12:258. doi: 10.1186/1471-2164-12-258.