Temu̲ ir bo̲ni 'nar 'Clear 'nar?
Ar me̲ti hingi lleva ar mutación. Hingi da nte ar enfermedad ne hinda thogi.
Mixi Factor Xii Deficiency Variant 1 (FXIIdef1)
The Factor XII Deficiency Variant 1 (FXIIdef1) DNA test in cats is essential for identifying a genetic mutation that affects blood clotting. This hereditary condition can lead to prolonged bleeding times, making early detection crucial for effective management. By using the FXIIdef1 DNA test, breeders and veterinarians can screen cats to prevent passing this variant to offspring. Accurate genetic testing helps maintain healthy feline populations and supports informed breeding decisions. Understanding the FXIIdef1 mutation also aids in diagnosing unexplained bleeding disorders in cats. Invest in the Factor XII Deficiency Variant 1 DNA test to ensure your cat’s health and well-being. Early genetic screening promotes better care and longevity for affected cats.
Abreviatura: FXIIdef1
Mutación analizada: F12 c.1321del
Herencia: Autosómica recesiva
Acrónimo
FXIIdef1
Frecuencia observada
Severidad clínica
Clasificación clínica
Enfermedades Cardiovasculares
Mutación analizada
F12 c.1321del
p.(L441Cfs*119)
p.(L441Cfs*119)
Modo herencia
Autosómica recesiva
Resumen ar ntsa̲:
The Factor XII Deficiency Variant 1 (FXIIdef1) in cats is a genetic mutation affecting blood clotting. Cats with this variant may have prolonged clotting times but typically do not show bleeding symptoms. This condition is important to identify before surgeries or dental procedures to prevent complications. DNA testing can accurately detect the presence of FXIIdef1, allowing veterinarians to manage affected cats safely. Early diagnosis helps ensure proper care and reduces risks during medical treatments.
Disponible ndezu̲ ar pack: Basic
Nuna ar ntsa̲ ADN xi incluido a partir de ma pack Basic — ne 'nehe 'nar xe̲ni ja ya paquetes Basic, Standard, Advanced, Complete.
Ga paquetes ntsa̲ ADN →Da 'ñets'i ar paquete nä'ä mäs xi hño ar adapte ja ár estrategia ar reproducción wa nzaki yá me̲ti.
Introduction to Factor XII Deficiency Variant 1 (FXIIdef1)
Factor XII Deficiency Variant 1 (FXIIdef1) is a hereditary coagulation disorder affecting cats. This condition arises due to mutations in the F12 gene, which is responsible for producing coagulation factor XII, a crucial protein in the blood clotting cascade. A deficiency in this factor can lead to various clinical issues, primarily related to improper blood clotting mechanisms.
Understanding the Role of Factor XII
Factor XII, also known as Hageman factor, plays an essential role in the initiation of the intrinsic pathway of blood coagulation. When activated, it triggers a series of enzymatic reactions that ultimately lead to the formation of a stable blood clot. In cats with FXIIdef1, the deficiency in this factor can compromise the coagulation process, leading to bleeding tendencies even in the absence of external trauma.
Clinical Manifestations of FXIIdef1
Cats affected by FXIIdef1 may exhibit various signs related to bleeding disorders. Common clinical manifestations include prolonged bleeding from minor wounds, excessive bruising, and spontaneous bleeding episodes. These symptoms can vary in severity among affected individuals, and some cats may remain asymptomatic until subjected to surgical procedures or traumatic events.
Diagnosis of FXIIdef1
The diagnosis of Factor XII Deficiency Variant 1 typically involves genetic testing to identify mutations in the F12 gene. This specific DNA test can confirm the presence of FXIIdef1 and help differentiate it from other coagulation disorders. It is essential for veterinarians to accurately diagnose this condition to provide appropriate management and care for affected cats.
Management and Treatment
While there is currently no cure for FXIIdef1, management strategies focus on minimizing the risk of bleeding episodes. This may involve avoiding surgical procedures whenever possible and implementing precautionary measures during routine veterinary care. In cases of bleeding, supportive care and interventions may be required to stabilize the cat and manage the clinical signs effectively.
Conclusion
Factor XII Deficiency Variant 1 (FXIIdef1) is a significant coagulation disorder in cats that requires careful recognition and management. Understanding this condition is crucial for pet owners and veterinarians alike, as it impacts the overall health and wellbeing of affected cats. Early diagnosis through DNA testing can facilitate appropriate care strategies, ensuring that cats with FXIIdef1 can lead healthy lives despite the challenges posed by this genetic condition.
Ar raza reconocida pa ar ntsa̲: Factor Xii Deficiency Variant 1 (FXIIdef1)
- Abyssinian
- Aegean
- Alpine Lynx
- Altai
- American Bobtail
- American Bobtail Longhair
- American Bobtail Shorthair
- American Burmese
- American Curl
- American Curl Longhair
- American Curl Shorthair
- American Fold Longhair
- American Fold Shorthair
- American Keuda
- American Longhair
- American Lynx
- American Miniature Cat
- American Polydactyl
- American Ringtail
- American Shorthair
- American Straight Long Hair
- American Straight Shorthair
- American Wirehair
- Anatoli
- Aphrodite
- Aphrodite Giant
- Aphrodite's Giant Longhair
- Aphrodite's Giant Shorthair
- Arabian Mau
- Asian
- Asian Leopard Cat
- Asian Longhair
- Asian Semi-longhair
- Asian Shorthair
- Australian Bombay
- Australian Mist
- Aztec
- Balinese
- Bambino
- Bambino Curl
- BamBob
- Bengal
- Bengal Longhair
- Birman
- Bobcat
- Bohemian Rex
- Bombay
- Bramble
- Brazilian Shorthair
- Bristol
- British Ice Longhair
- British Ice Shorthair
- British Longhair
- British Shorthair
- Burmese
- Burmese European
- Burmese Longhair
- Burmilla
- Burmilla Longhair
- Burmilla Shorthair
- California Spangled
- California Toyger
- Californian Rex
- Canadian Feral Cat
- Canadian Sphynx
- Caracal
- Celtic
- Celtic Shorthair
- Ceylon
- Chantilly-Tiffany
- Chartreux
- Chausie
- Chinchilla Longhair
- Chinese Harlequin
- Chinese Li Hua
- Chinese Tank Cat
- Classicat
- Colorpoint Shorthair
- Companion Cat
- Copper
- Cornish Rex
- Cornish Rex Longhair
- Curly Tail Cat
- Cymric
- Cyprus
- Desert Lynx
- Deutsch Langhaar
- Devon Rex
- Domestic Longhair
- Domestic medium-haired
- Domestic Shorthair
- Don Sphynx
- Donskoy
- Dossow
- Dragon Li
- Dwelf
- Egyptian Mau
- Elf
- European
- European Burmese
- European Shorthair
- Exotic
- Exotic Shorthair
- Experimental
- Fishing Cat
- Foldex
- Foreign White
- Foreign White Longhair
- Foreign White Shorthair
- Gao Taem
- Genetta
- Geoffroy's Cat
- German Longhair
- German Rex
- Havana
- Havana Brown
- Hemingway Curl
- Hibernian Lynx
- Highland Fold
- Highland Lynx
- Highland Straight
- Highlander
- Highlander Longhair
- Highlander Shorthair
- Himalayan
- House Cat Longhair
- House Cat Shorthair
- Household Pet
- Household Pet Kitten
- Household Pet Longhair
- Household Pet Shorthair
- Isle of Man Longhair
- Isle of Man Shorthair
- Jaguarette
- Jaguarundi Curl
- Japanese Bobtail
- Japanese Bobtail Longhair
- Japanese Bobtail Shorthair
- Japanese domestic
- Javanese
- Jungala
- Jungle Cat
- Jungle Curl
- Jungle Lynx
- Junglebob
- Kanaani
- Karelian Bobtail
- Karelian Bobtail Longhair
- Khao Manee
- Khaomanee
- Kinkalow
- Korat
- Korean Bobtail
- Korn Ja
- Kurilian Bobtail
- Kurilian Bobtail Longhair
- Kurilian Bobtail Shorthair
- Lambkin
- LaPerm
- LaPerm Longhair
- LaPerm Shorthair
- Lykoi
- Maine Coon
- Maine Coon Polydactyl
- Manx
- Manx Longhair
- Manx Shorthair
- Me-kong Bobtail
- Meerkat
- Mekong Bobtail
- Minskin
- Minuet
- Minuet Longhair
- Mixed Breed
- Mohave Bob
- Mojave Spotted
- Mokave Jag Cat
- Mountain Bob
- Munchkin
- Munchkin Longhair
- Napoleon
- Nebelung
- Neva Masquerade
- Niebelung
- Non Recognized Hairless
- Non Recognized Longhair
- Non Recognized Shorthair
- Norwegian Forest Cat
- Ocicat
- Ojos Azules
- Oregon Rex (extinct)
- Oriental
- Oriental Bicolor
- Oriental Longhair
- Oriental Shorthair
- Original Longhair
- Owyhee Bob
- Pantherette
- Persian
- Peterbald
- Pharaoh
- Pixiebob
- Pixiebob Longhair
- Puppykat
- Raas
- Ragamuffin
- Ragdoll
- Ruffle
- Russian
- Russian Black
- Russian Blue
- Russian Tabby
- Russian White
- Rusty Spotted Cat
- Sacred Birman
- Safari
- Sam Sawet
- Sashkin Rex
- Savannah
- Scottish Fold
- Scottish Fold Longhair
- Scottish Longhair
- Scottish Shorthair
- Scottish Straight
- Scottish Straight Longhair
- Selkirk Rex
- Selkirk Rex Longhair
- Selkirk Rex Shorthair
- Selkirk Straight
- Serengeti
- Serrade Petit
- Serval
- Siamese
- Siamese Longhair
- Siberian
- Singapura
- Skookum
- Snowbob
- Snowshoe
- Sokoke
- Somali
- Sphynx
- Suffolk
- Suphalak
- Tennessee Bobtail
- Tennessee Rex
- Thai
- Thai Blue Point
- Thai Lilac
- Thai Lilac Point
- Tiffanie
- Tigrette
- Tonkinese
- Tonkinese Longhair
- Tonkinese Shorthair
- Toybob
- Toyger
- Traditional Siamese
- Transylvanian
- Tundra
- Turkish Angora
- Turkish Van
- Turkish Vankedisi
- Ukrainian Levkoy
- Unknown
- Ural Rex
- Ural Rex Longhair
- Vienna Woods
- Viverral
- York Chocolate
🧬 Interpretation of genotypes FXIIdef1
Genotipo
Dätä
🟡 N/N
Hingi — portador — 'ñotho ar riesgo
🟡 N/FXIIdef1
Carrier — 'ñotho ar riesgo
❌ FXIIdef1/FXIIdef1
Afectado — jar riesgo
FAQ: da 'yo̲de ar interpretación
¿Ge 'nar 'nar Carrier 'nar?
Hi'nä. Ar me̲ti ar nu'bu̲ da nthe̲hu̲ 'ra saludable pe tsa̲ da ungumfädi ar mutación ár descendencia.
¿Temu̲ thogi nu'bu̲ 'nar me̲ti 'nar afectado 'nar?
Lleva yoho ya kopya mutadas. Ya signos clínicos ar esperan dependiendo de ar enfermedad. Hingi da da criado.
¿Yogo'ä 'bu̲i ya hñäki ja ya macho yá femenino?
ra enfermedades gi 'bu̲hu̲ vinculadas ko ar nthä'mi, nä'ä ár hmä varía dependiendo de ar nt'ot'e ar me̲ti.
Predict descendencia
N/N (hingi-portador)
N/FXIIdef1 (Portador)
FXIIdef1/FXIIdef1 (afectado)
Nt'a̲ni frecuentes test ADN
¿Temu̲ detecta nuna ntsa̲ ADN?
This DNA test detects the mutation associated with Factor Xii Deficiency Variant 1 (FXIIdef1) in order to identify clear, carrier, or at-risk animals.
¿Yogo'ä probar 'nar me̲ti reproductor?
Ntsa̲ ADN ayuda ja ya criadores planear apareamientos mäs seguros ne reducir riesgo ungumfädi ar mutación ja ar descendencia.
¿Teme ra modo herencia nuna ar ntsa̲?
Modo herencia reportado pa nuna ntsa̲ ar Autosómica recesiva.
¿Temu̲ ar mutación ar analiza jar nuna ntsa̲?
This test analyses the mutation F12 c.1321del.
¿'Bu̲i 'nar me̲ti portador necesariamente afectado?
Hingi nese. Interpretación bi jagu̲ju̲ hmu herencia ne ar genotipo resultante.
Referencias
Bender D E, Kloos M T, Pontius J U, Hinsdale M E, Bellinger D A. Molecular characterization of cat factor XII gene and identification of a mutation causing factor XII deficiency in a domestic shorthair cat colony. Vet Pathol. 2015 Mar;52(2):312-20. doi: 10.1177/0300985814532821. Epub 2014 May 2.