Was bedeutet "Clear"?
Das Tier trägt die Mutation nicht. Es wird nicht zur Krankheit kommen und werde es nicht weitergeben.
Pferd Androgenunempfindlichkeitssyndrom beim Warmblut (AIS-W)
The Androgen Insensitivity Syndrome (AIS) DNA test in Warmblood horses is essential for accurate genetic screening and breeding decisions. AIS affects the horse’s response to male hormones, potentially leading to infertility or ambiguous sexual development. By using the AIS DNA test, breeders can identify carriers and avoid mating pairs that may produce affected offspring. This test ensures healthier Warmblood populations and supports responsible breeding practices. Early detection through AIS testing helps maintain the breed’s quality and performance standards. Trust reliable laboratories offering precise AIS DNA testing for Warmblood horses. Optimize your breeding program with comprehensive genetic insights today.
Abkürzung : AIS-W
Analysierte Mutation: AR c.1630_1654del
Nachlass : X-chromosomal rezessiv
Akronym
AIS-W
Beobachtete Häufigkeit
Klinischer Schweregrad
Klinische Klassifizierung
Endokrine Erkrankungen
Analysierte Mutation
AR c.1630_1654del
Art der Vererbung
X-chromosomal rezessiv (Vollständig)
Testzusammenfassung:
The Androgen Insensitivity Syndrome (AIS) DNA test in Warmblood horses helps identify individuals with this genetic condition, which affects sexual development. AIS occurs when a horse is genetically male (XY) but is resistant to male hormones, leading to female or ambiguous physical traits. Testing allows breeders to detect carriers and avoid breeding affected horses, ensuring healthier offspring. Early identification through DNA testing supports better management and breeding decisions. This test is crucial for maintaining the integrity and health of Warmblood populations.
Erhältlich in der Packung: Basic
Dieser DNA-Test ist ab unserem Paket enthalten Basic — und ist auch Teil der Packungen Basic, Standard, Advanced, Complete.
DNA-Testpakete anzeigen →Wählen Sie das Paket, das am besten zu Ihrer Zucht- oder Gesundheitsstrategie Ihrer Tiere passt.
Understanding Androgen Insensitivity Syndrome (AIS) in Horses
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in horses. This disorder is primarily characterized by a resistance to androgens, which are male hormones that play a crucial role in the development of male physical traits. In horses affected by AIS, even though the genetic makeup may indicate a male (XY chromosomes), the physical characteristics can appear more feminine due to the body's inability to respond to androgens.
Genetic Basis of AIS
The condition is linked to mutations in the androgen receptor gene, which impairs the horse's ability to utilize androgens effectively. As a result, horses with AIS may not exhibit typical male behaviors or physical traits, such as the development of stallion-like musculature or reproductive organs. Instead, these horses often present with external characteristics that resemble those of females, leading to potential challenges in breeding and management.
Clinical Signs of AIS
Horses with AIS may display a variety of clinical signs, including the presence of undescended testes (cryptorchidism), an absence of fully developed male reproductive organs, and external genitalia that appear female. Additionally, affected horses may not exhibit stallion-like behaviors, which can complicate their use in breeding programs. It is important for owners and breeders to recognize these signs early to make informed decisions regarding the management of affected horses.
Importance of DNA Testing for AIS
DNA testing for Androgen Insensitivity Syndrome is crucial for identifying carriers and affected individuals within the Warmblood population. By understanding the genetic status of horses, breeders can make more informed breeding decisions, ultimately aiming to reduce the prevalence of AIS in future generations. The availability of a reliable DNA test allows for proactive measures to be taken, ensuring the health and welfare of the horses involved.
Management and Implications of AIS
Managing horses with AIS involves a comprehensive approach that includes proper veterinary care and consideration of the horse's unique needs. Affected horses may require specific management strategies to ensure their well-being. For breeders, understanding the genetic implications of AIS is essential for maintaining the integrity of breeding programs and preventing the continuation of the syndrome within the population.
Fazit
Androgen Insensitivity Syndrome represents a significant genetic consideration in the equine world, particularly within Warmblood breeds. By investing in DNA testing and understanding the implications of this syndrome, breeders and owners can work together to promote healthier breeding practices and improve the overall genetics of their horses.
Für die Prüfung anerkannte Rasse: Androgenunempfindlichkeitssyndrom beim Warmblut (AIS-W)
- Warmblood
🧬 Interpretation of genotypes AIS-W
Genotyp
Status
🟡 N/N
Nicht-Träger - Kein Risiko
❌ ♂ N/AIS-W
Betroffen - Gefährdet
🟡 ♀ N/AIS-W
Carrier - Kein Risiko
❌ AIS-W/AIS-W
Betroffen - Gefährdet
FAQ: das Verständnis der Interpretation
Ist ein „Carrier“ ernsthaft?
Nein. Das Tier ist im Allgemeinen gesund, kann die Mutation aber auf sein Tier übertragen Nachkommen.
Was passiert, wenn ein Tier "betroffen" ist?
Es trägt zwei mutierte Kopien. Klinische Symptome sind abhängig davon zu erwarten die Krankheit. Es sollte nicht gezüchtet werden.
Warum gibt es Unterschiede zwischen Männern und Frauen?
Einige Krankheiten sind geschlechtsgebunden, daher variiert ihre Ausprägung je nach Erkrankung Geschlecht des Tieres.
Nachkommen vorhersagen
N/N (nicht-trager)
N/AIS-W (Träger)
AIS-W/AIS-W (Betroffen)
Häufig gestellte Fragen zum DNA-Test
Was erkennt dieser DNA-Test?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Warmblood (AIS-W) in order to identify clear, carrier, or at-risk animals.
Warum ein Zuchttier testen?
DNA-Tests helfen Züchtern, sicherere Paarungen zu planen und das Risiko einer Übertragung der Mutation auf die Nachkommen zu verringern.
Was ist der Vererbungsmodus dieses Tests?
Der für diesen Test gemeldete Vererbungsmodus ist X-Linked Recessive.
Welche Mutation wird in diesem Test analysiert?
This test analyses the mutation AR c.1630_1654del.
Ist ein Trägertier zwangsläufig betroffen?
Nicht unbedingt. Die Interpretation hängt vom Vererbungsmuster und dem resultierenden Genotyp ab.
Referenzen
Welsford G Eastman, Munk Rikke, Villagómez Daniel A F, Hyttel Poul, King W Allan, Revay Tamas. Androgen Insensitivity Syndrome in a Family of Warmblood Horses Caused by a 25-bp Deletion of the DNA-Binding Domain of the Androgen Receptor Gene. Sex Dev. 2017;11(1):40-45. doi: 10.1159/000455114. Epub 2017 Feb 14.