O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cavalo Síndrome de insensibilidade androgênica em sangue quente (AIS-W)
The Androgen Insensitivity Syndrome (AIS) DNA test in Warmblood horses is essential for accurate genetic screening and breeding decisions. AIS affects the horse’s response to male hormones, potentially leading to infertility or ambiguous sexual development. By using the AIS DNA test, breeders can identify carriers and avoid mating pairs that may produce affected offspring. This test ensures healthier Warmblood populations and supports responsible breeding practices. Early detection through AIS testing helps maintain the breed’s quality and performance standards. Trust reliable laboratories offering precise AIS DNA testing for Warmblood horses. Optimize your breeding program with comprehensive genetic insights today.
Abreviatura: AIS-W
Mutação analisada: AR c.1630_1654del
Herança: Recessivo ligado ao X
Acrônimo
AIS-W
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Endócrinas
Mutação analisada
AR c.1630_1654del
Modo de herança
Recessivo ligado ao X (Completo)
Resumo do teste:
The Androgen Insensitivity Syndrome (AIS) DNA test in Warmblood horses helps identify individuals with this genetic condition, which affects sexual development. AIS occurs when a horse is genetically male (XY) but is resistant to male hormones, leading to female or ambiguous physical traits. Testing allows breeders to detect carriers and avoid breeding affected horses, ensuring healthier offspring. Early identification through DNA testing supports better management and breeding decisions. This test is crucial for maintaining the integrity and health of Warmblood populations.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Androgen Insensitivity Syndrome (AIS) in Horses
Androgen Insensitivity Syndrome (AIS) is a genetic condition that affects the development of sexual characteristics in horses. This disorder is primarily characterized by a resistance to androgens, which are male hormones that play a crucial role in the development of male physical traits. In horses affected by AIS, even though the genetic makeup may indicate a male (XY chromosomes), the physical characteristics can appear more feminine due to the body's inability to respond to androgens.
Genetic Basis of AIS
The condition is linked to mutations in the androgen receptor gene, which impairs the horse's ability to utilize androgens effectively. As a result, horses with AIS may not exhibit typical male behaviors or physical traits, such as the development of stallion-like musculature or reproductive organs. Instead, these horses often present with external characteristics that resemble those of females, leading to potential challenges in breeding and management.
Clinical Signs of AIS
Horses with AIS may display a variety of clinical signs, including the presence of undescended testes (cryptorchidism), an absence of fully developed male reproductive organs, and external genitalia that appear female. Additionally, affected horses may not exhibit stallion-like behaviors, which can complicate their use in breeding programs. It is important for owners and breeders to recognize these signs early to make informed decisions regarding the management of affected horses.
Importance of DNA Testing for AIS
DNA testing for Androgen Insensitivity Syndrome is crucial for identifying carriers and affected individuals within the Warmblood population. By understanding the genetic status of horses, breeders can make more informed breeding decisions, ultimately aiming to reduce the prevalence of AIS in future generations. The availability of a reliable DNA test allows for proactive measures to be taken, ensuring the health and welfare of the horses involved.
Management and Implications of AIS
Managing horses with AIS involves a comprehensive approach that includes proper veterinary care and consideration of the horse's unique needs. Affected horses may require specific management strategies to ensure their well-being. For breeders, understanding the genetic implications of AIS is essential for maintaining the integrity of breeding programs and preventing the continuation of the syndrome within the population.
Conclusão
Androgen Insensitivity Syndrome represents a significant genetic consideration in the equine world, particularly within Warmblood breeds. By investing in DNA testing and understanding the implications of this syndrome, breeders and owners can work together to promote healthier breeding practices and improve the overall genetics of their horses.
Raça reconhecida para o teste: Síndrome de insensibilidade androgênica em sangue quente (AIS-W)
- Warmblood
🧬 Interpretation of genotypes AIS-W
Genótipo
Status
🟡 N/N
Não portador - sem risco
❌ ♂ N/AIS-W
Afetados - Em risco
🟡 ♀ N/AIS-W
Transportadora - Sem Risco
❌ AIS-W/AIS-W
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/AIS-W (Operadora)
AIS-W/AIS-W (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Androgen Insensitivity Syndrome In Warmblood (AIS-W) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é X-Linked Recessive.
Qual mutação é analisada neste teste?
This test analyses the mutation AR c.1630_1654del.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Welsford G Eastman, Munk Rikke, Villagómez Daniel A F, Hyttel Poul, King W Allan, Revay Tamas. Androgen Insensitivity Syndrome in a Family of Warmblood Horses Caused by a 25-bp Deletion of the DNA-Binding Domain of the Androgen Receptor Gene. Sex Dev. 2017;11(1):40-45. doi: 10.1159/000455114. Epub 2017 Feb 14.