Beth mae “Clir” yn ei olygu?
Nid yw'r anifail yn cario'r treiglad. Ni fydd yn datblygu'r afiechyd ac ni fydd yn ei drosglwyddo.
Ci Clefyd Storio Glycogen Vii Mewn Ci Sofliar Almaenig (GSDVII-DW)
Glycogen Storage Disease VII (GSDVII) is a genetic condition that affects the Deutscher Wachtelhund, leading to muscle weakness and exercise intolerance. A DNA test for GSDVII is crucial for responsible breeding, helping to identify carriers and prevent the disease from being passed on to future generations. By testing your Deutscher Wachtelhund, you can ensure a healthier lineage and contribute to the overall well-being of the breed. Early detection through a simple saliva or blood test enables proactive management of the condition. Understanding GSDVII is essential for breeders and dog owners alike. Protect your pet's health by choosing DNA testing today. Invest in your dog's future and promote genetic health within the Deutscher Wachtelhund community.
Talfyriad: GSDVII-DW
Treiglad wedi'i ddadansoddi : PFKM c.550C>T
Etifeddiaeth: Autosomal Reciliol
Acronym
GSDVII-DW
Amlder a arsylwyd
Difrifoldeb clinigol
Dosbarthiad clinigol
Clefydau Metabolaidd
Treiglad wedi'i ddadansoddi
PFKM c.550C>T
p.(R184W)
p.(R184W)
Modd etifeddiaeth
Autosomal Reciliol (Cyflawn)
Crynodeb prawf:
Glycogen Storage Disease VII (GSDVII) is a hereditary condition affecting the Deutscher Wachtelhund, a breed known for its hunting prowess. This genetic disorder impairs the dog's ability to metabolize glycogen, leading to muscle weakness and exercise intolerance. A DNA test can identify carriers and affected individuals, helping breeders make informed decisions to minimize the disease's prevalence. Early diagnosis through genetic testing can significantly improve the quality of life for affected dogs. Responsible breeding practices are essential to ensure the health and well-being of future generations of this beloved breed.
Ar gael o'r pecyn: Basic
Mae'r prawf DNA hwn wedi'i gynnwys gan ddechrau o'n pecyn Basic - ac mae hefyd yn rhan o'r pecynnau Basic, Standard, Advanced, Complete.
Gweld Pecynnau Prawf DNA →Dewiswch y pecyn sy'n gweddu orau i'ch strategaeth bridio neu iechyd eich anifeiliaid.
Understanding DNA Testing for Glycogen Storage Disease VII in Deutscher Wachtelhund
Glycogen Storage Disease Type VII (GSDVII), also known as Tarui's disease, is a rare inherited metabolic disorder that affects the muscle cells of dogs, including the Deutscher Wachtelhund. This condition results from a deficiency in the enzyme phosphofructokinase (PFK), which plays a crucial role in the glycolytic pathway responsible for energy production during muscle activity.
Pathophysiology of GSDVII in Deutscher Wachtelhund
In affected dogs, the lack of functional PFK enzyme impairs the breakdown of glucose within muscle cells, leading to an abnormal accumulation of glycogen and other metabolic byproducts. This disruption causes muscle weakness, exercise intolerance, and potential muscle damage, especially during periods of exertion. The energy deficiency within muscle tissues can lead to episodes of weakness or collapse following physical activity.
Genetic Basis of GSDVII
GSDVII in Deutscher Wachtelhund is inherited in an autosomal recessive manner, meaning that an affected dog must inherit two copies of the mutated gene—one from each parent—to develop the disease. Carriers, with only one copy of the mutation, typically do not display clinical signs but can pass the mutation to their offspring. Identifying carriers and affected individuals is essential for responsible breeding and disease management.
Importance of DNA Testing for GSDVII
DNA testing provides a definitive method for determining the presence or absence of the genetic mutation associated with GSDVII. This testing allows breeders and veterinarians to make informed decisions to reduce the incidence of affected puppies. Early diagnosis through genetic screening can also help manage the condition by adjusting exercise routines and providing supportive care to affected dogs, improving their quality of life.
Brid yn cael ei gydnabod ar gyfer y prawf: Clefyd Storio Glycogen Vii Mewn Ci Sofliar Almaenig (GSDVII-DW)
- Deutscher Wachtelhund
🧬 Interpretation of genotypes GSDVII-DW
Genoteip
Statws
🟡 N/N
Heb fod yn gludwr - Dim Risg
🟡 N/GSDVII-DW
Cludwr - Dim Risg
❌ GSDVII-DW/GSDVII-DW
Wedi'i Effeithio - Mewn Perygl
FAQ: deall y dehongliad
Ydy “Cludwr” yn ddifrifol?
Mae'r anifail yn gyffredinol iach ond gall drosglwyddo'r treiglad iddo epil.
Beth os yw anifail yn cael ei “Effeithio”?
Mae'n cario dau gopi treigledig. Disgwylir arwyddion clinigol yn dibynnu ar y clefyd. Ni ddylid ei fridio.
Pam mae gwahaniaethau rhwng gwryw / benyw?
Mae rhai afiechydon yn gysylltiedig â rhyw, felly mae eu mynegiant yn amrywio yn dibynnu ar y rhyw anifail.
Rhagfynegi Epil
N/N (heb-fod-yn-gludwr)
N/GSDVII-DW (Cludwr)
GSDVII-DW/GSDVII-DW (Wedi'i effeithio)
Cwestiynau Cyffredin Prawf DNA
Beth mae'r prawf DNA hwn yn ei ganfod?
This DNA test detects the mutation associated with Glycogen Storage Disease VII In Deutscher Wachtelhund (GSDVII) in order to identify clear, carrier, or at-risk animals.
Pam rhoi prawf ar anifail magu?
Mae profion DNA yn helpu bridwyr i gynllunio paru mwy diogel a lleihau'r risg o drosglwyddo'r mwtaniad i'r epil.
Beth yw modd etifeddiaeth y prawf hwn?
Y modd etifeddu a adroddwyd ar gyfer y prawf hwn yw Autosomal Recessive.
Pa dreiglad sy'n cael ei ddadansoddi yn y prawf hwn?
This test analyses the mutation PFKM c.550C>T.
A effeithir ar anifail cludo o reidrwydd?
Ddim o reidrwydd. Mae dehongliad yn dibynnu ar y patrwm etifeddiaeth a'r genoteip canlyniadol.
Cyfeiriadau
Inal Gultekin G, Raj K, Lehman S, Hillström A, Giger U. Missense mutation in PFKM associated with muscle-type phosphofructokinase deficiency in the Wachtelhund dog. Mol Cell Probes. 2012 Dec;26(6):243-7. doi: 10.1016/j.mcp.2012.02.004. Epub 2012 Mar 16.