狗 凯利蓝梗犬多系统退化（CMSD-KBT）

按品种或临床分类过滤 DNA 测试

The Canine Multiple System Degeneration (CMSD) DNA test is essential for Kerry Blue Terrier owners to ensure their dogs' health. CMSD is a hereditary neurological disorder affecting coordination and movement in Kerry Blue Terriers. Early genetic testing helps identify carriers and affected dogs, enabling responsible breeding decisions. By using the CMSD DNA test, breeders can reduce the risk of passing this debilitating condition to future generations. This test provides accurate, reliable results, promoting the well-being of your Kerry Blue Terrier. Protect your dog’s health with the CMSD DNA test today. Regular screening supports a healthier, happier canine companion.

缩写 ： CMSD-KBT

分析突变： SERAC1 c.1536G>A

继承： 常染色体隐性遗传

可从包装中获取： Basic

我们的包装中已包含此 DNA 测试 Basic — 也是包的一部分 Basic, Standard, Advanced, Complete。

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Understanding Canine Multiple System Degeneration in Kerry Blue Terriers (CMSD-KBT)

Canine Multiple System Degeneration (CMSD) is a progressive neurological disorder that primarily affects Kerry Blue Terriers. This condition is characterized by the degeneration of multiple systems within the nervous system, leading to a range of debilitating symptoms that can significantly impact the quality of life of affected dogs.

Symptoms of CMSD-KBT

The symptoms of CMSD-KBT typically manifest in early to mid-adulthood, although the age of onset can vary. Common signs include balance problems, difficulty walking, and a general lack of coordination. As the disease progresses, affected dogs may exhibit muscle weakness, tremors, and a decline in overall mobility. In some cases, dogs may also experience changes in behavior, such as increased anxiety or a reluctance to engage in normal activities.

Pathophysiology of CMSD-KBT

The underlying cause of CMSD-KBT lies in genetic mutations that affect the nervous system's ability to function properly. These mutations lead to the degeneration of nerve cells, which in turn causes a breakdown of communication between the brain and the body. This disruption results in the clinical symptoms observed in affected dogs. Understanding the genetic basis of CMSD-KBT is crucial for breeders and owners, as it allows for informed decisions regarding breeding practices and the management of affected animals.

受影响狗的管理和护理

While there is currently no cure for CMSD-KBT, management strategies can help improve the quality of life for affected dogs. Regular veterinary check-ups are essential for monitoring the progression of the disease and addressing any health concerns that arise. Physical therapy and rehabilitation exercises can assist in maintaining mobility and strength. Additionally, providing a safe and supportive environment can help dogs cope with their symptoms and enhance their overall well-being.

结论

Canine Multiple System Degeneration in Kerry Blue Terriers is a serious condition that requires attention from dog owners and breeders. By understanding the symptoms, underlying causes, and management strategies associated with CMSD-KBT, stakeholders can work towards improving the lives of affected dogs while making informed breeding decisions to reduce the prevalence of this condition in the breed.

被认可参加测试的品种： 凯利蓝梗犬多系统退化（CMSD-KBT）

• Kerry Blue Terrier

🧬 Interpretation of genotypes CMSD-KBT

❓ 了解有关基因型解释的更多信息

常见问题解答：理解解释

“清晰”是什么意思？

该动物不携带突变。就不会发展成这种疾病 并且不会将其传递下去。

“航母”是认真的吗？

不会。该动物通常是健康的，但可以将突变传播给它的 后代。

如果动物“受到影响”怎么办？

它携带两个突变的副本。预计临床症状取决于 这种疾病。它不应该被培育。

为什么男性/女性之间存在差异？

有些疾病与性别相关，因此其表现因性别而异 动物的性别。

预测后代

DNA 测试常见问题解答

这个 DNA 测试检测到什么？

This DNA test detects the mutation associated with Canine Multiple System Degeneration In Kerry Blue Terrier (CMSD-KBT) in order to identify clear, carrier, or at-risk animals.

为什么要测试繁殖动物？

DNA 测试有助于饲养员计划更安全的交配并降低将突变传播给后代的风险。

这个测试的继承模式是什么？

该测试报告的遗传模式是常染色体隐性遗传。

此测试分析哪种突变？

This test analyses the mutation SERAC1 c.1536G>A.

携带动物是否必然受到影响？

未必。解释取决于遗传模式和产生的基因型。

参考

Johnson GS, Mhlanga-Mutangadura T, Morava E, Kozicz T, Taylor JF, O’Brien DP, Schnabel RD. Canine Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract]. Presented at the 63rd Annual Meeting of the American Society of Human Genetics in Boston, Massachusetts; 2013 Oct 22-26.