O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Distrofia Muscular Congênita em American Staffordshire Terrier (CMD-AST)
The Congenital Muscular Dystrophy (CMD) DNA test in American Staffordshire Terriers is essential for responsible breeders and owners. This genetic test helps identify carriers of CMD, a serious inherited muscle disorder affecting this breed. Early detection through DNA testing enables informed breeding decisions, reducing the risk of passing CMD to puppies. By using the CMD DNA test, breeders can promote healthier bloodlines and improve the overall well-being of American Staffordshire Terriers. Regular testing supports proactive health management and prevents the spread of this debilitating condition. Ensure your dog’s health with reliable CMD DNA testing today. Protect your American Staffordshire Terrier’s future with accurate genetic screening.
Abreviatura: CMD-AST
Mutação analisada: COL6A3 c.6398del
Herança: Autossômico Recessivo
Acrônimo
CMD-AST
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Musculares
Mutação analisada
COL6A3 c.6398del
p.(P2133Rfs*109)
p.(P2133Rfs*109)
Modo de herança
Autossômico Recessivo
Resumo do teste:
The DNA test for Congenital Muscular Dystrophy (CMD) in American Staffordshire Terriers helps identify carriers of this genetic disorder. CMD is a serious condition that affects muscle development and strength from birth. Early detection through genetic testing allows breeders to make informed decisions and reduce the risk of passing the disease to puppies. This test is essential for maintaining the health and well-being of the breed. Responsible breeding practices rely on such genetic screenings to prevent CMD in future generations.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Congenital Muscular Dystrophy (CMD) in American Staffordshire Terriers
Congenital Muscular Dystrophy (CMD) is a hereditary condition that primarily affects the muscle structure and function in dogs, particularly in American Staffordshire Terriers. This genetic disorder leads to progressive muscle degeneration, which can significantly impair mobility and quality of life. CMD is characterized by a defect in the genes responsible for muscle fiber integrity, leading to weakness and muscle wasting.
Sinais e Sintomas Clínicos
Dogs affected by CMD may exhibit a range of clinical signs, often noticeable at a young age. Common symptoms include muscle weakness, difficulty in standing or walking, and an abnormal gait. As the condition progresses, affected dogs may show signs of exercise intolerance and fatigue, and they may struggle to perform normal activities like running or jumping. Muscle atrophy, particularly in the hindquarters, is also a hallmark of this condition.
Genetic Basis of CMD
The genetic basis for CMD in American Staffordshire Terriers stems from mutations in specific genes that are crucial for muscle function and integrity. These mutations disrupt the production of proteins that are vital for muscle cell stability, leading to the clinical manifestations observed in affected dogs. Understanding the genetic underpinnings of CMD is essential for breeders and owners to make informed decisions regarding breeding practices and management of the condition.
Diagnosis of CMD
Diagnosis of Congenital Muscular Dystrophy typically involves a combination of clinical evaluation and genetic testing. Veterinarians will assess the dog’s physical condition, review its history, and may perform muscle biopsies or other diagnostic tests to confirm the presence of the disorder. Genetic testing can provide definitive confirmation of CMD, helping to identify carriers and affected individuals within a breeding program.
Gestão e Cuidado
Currently, there is no cure for CMD, and management focuses on improving the quality of life for affected dogs. This may involve physical therapy, weight management, and supportive care to maintain mobility and reduce discomfort. Regular veterinary check-ups are crucial to monitor the progression of the disease and to adjust care plans as needed. Providing a safe and comfortable environment is also essential to support the needs of dogs living with CMD.
Conclusão
Congenital Muscular Dystrophy in American Staffordshire Terriers is a serious genetic condition that requires careful management and understanding. Through awareness and responsible breeding practices, the impact of CMD can be minimized, ensuring healthier future generations. Owners and breeders should remain informed about the condition and work closely with veterinary professionals to support affected dogs.
Raça reconhecida para o teste: Distrofia Muscular Congênita em American Staffordshire Terrier (CMD-AST)
- American Staffordshire Terrier
🧬 Interpretation of genotypes CMD-AST
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/CMD-AST
Transportadora - Sem Risco
❌ CMD-AST/CMD-AST
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/CMD-AST (Operadora)
CMD-AST/CMD-AST (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Congenital Muscular Dystrophy In American Staffordshire Terrier (CMD-AST) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation COL6A3 c.6398del.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Jankelunas Leanne, Murthy Vishal D, Chen Annie V, Minor Katie M, Friedenberg Steven G, Cullen Jonah N, Guo Ling T, Mickelson James R, Shelton G Diane. Novel COL6A3 frameshift variant in American Staffordshire Terrier dogs with Ullrich-like congenital muscular dystrophy. J Vet Intern Med. 2023 Nov-Dec;37(6):2504-2509. doi: 10.1111/jvim.16862. Epub 2023 Sep 14.