¿Qué significa "claro"?
El animal no porta la mutación. No desarrollará la enfermedad. y no lo transmitiré.
Perro Distrofia muscular congénita en staffordshire terrier americano (CMD-AST)
The Congenital Muscular Dystrophy (CMD) DNA test in American Staffordshire Terriers is essential for responsible breeders and owners. This genetic test helps identify carriers of CMD, a serious inherited muscle disorder affecting this breed. Early detection through DNA testing enables informed breeding decisions, reducing the risk of passing CMD to puppies. By using the CMD DNA test, breeders can promote healthier bloodlines and improve the overall well-being of American Staffordshire Terriers. Regular testing supports proactive health management and prevents the spread of this debilitating condition. Ensure your dog’s health with reliable CMD DNA testing today. Protect your American Staffordshire Terrier’s future with accurate genetic screening.
Abreviatura: CMD-AST
Mutación analizada: COL6A3 c.6398del
Herencia : Autosómica recesiva
Acrónimo
CMD-AST
Frecuencia observada
Gravedad clínica
Clasificación clínica
Enfermedades musculares
Mutación analizada
COL6A3 c.6398del
p.(P2133Rfs*109)
p.(P2133Rfs*109)
Modo de herencia
Autosómica recesiva
Resumen de la prueba:
The DNA test for Congenital Muscular Dystrophy (CMD) in American Staffordshire Terriers helps identify carriers of this genetic disorder. CMD is a serious condition that affects muscle development and strength from birth. Early detection through genetic testing allows breeders to make informed decisions and reduce the risk of passing the disease to puppies. This test is essential for maintaining the health and well-being of the breed. Responsible breeding practices rely on such genetic screenings to prevent CMD in future generations.
Disponible en el paquete: Basic
Este test de ADN está incluido a partir de nuestro pack Basic — y también forma parte de los packs Basic, Standard, Advanced, Complete.
Ver paquetes de pruebas de ADN →Elige el pack que mejor se adapte a tu estrategia de cría o salud de tus animales.
Understanding Congenital Muscular Dystrophy (CMD) in American Staffordshire Terriers
Congenital Muscular Dystrophy (CMD) is a hereditary condition that primarily affects the muscle structure and function in dogs, particularly in American Staffordshire Terriers. This genetic disorder leads to progressive muscle degeneration, which can significantly impair mobility and quality of life. CMD is characterized by a defect in the genes responsible for muscle fiber integrity, leading to weakness and muscle wasting.
Signos y síntomas clínicos
Dogs affected by CMD may exhibit a range of clinical signs, often noticeable at a young age. Common symptoms include muscle weakness, difficulty in standing or walking, and an abnormal gait. As the condition progresses, affected dogs may show signs of exercise intolerance and fatigue, and they may struggle to perform normal activities like running or jumping. Muscle atrophy, particularly in the hindquarters, is also a hallmark of this condition.
Genetic Basis of CMD
The genetic basis for CMD in American Staffordshire Terriers stems from mutations in specific genes that are crucial for muscle function and integrity. These mutations disrupt the production of proteins that are vital for muscle cell stability, leading to the clinical manifestations observed in affected dogs. Understanding the genetic underpinnings of CMD is essential for breeders and owners to make informed decisions regarding breeding practices and management of the condition.
Diagnosis of CMD
Diagnosis of Congenital Muscular Dystrophy typically involves a combination of clinical evaluation and genetic testing. Veterinarians will assess the dog’s physical condition, review its history, and may perform muscle biopsies or other diagnostic tests to confirm the presence of the disorder. Genetic testing can provide definitive confirmation of CMD, helping to identify carriers and affected individuals within a breeding program.
Manejo y Cuidado
Currently, there is no cure for CMD, and management focuses on improving the quality of life for affected dogs. This may involve physical therapy, weight management, and supportive care to maintain mobility and reduce discomfort. Regular veterinary check-ups are crucial to monitor the progression of the disease and to adjust care plans as needed. Providing a safe and comfortable environment is also essential to support the needs of dogs living with CMD.
Conclusión
Congenital Muscular Dystrophy in American Staffordshire Terriers is a serious genetic condition that requires careful management and understanding. Through awareness and responsible breeding practices, the impact of CMD can be minimized, ensuring healthier future generations. Owners and breeders should remain informed about the condition and work closely with veterinary professionals to support affected dogs.
Raza reconocida para la prueba: Distrofia muscular congénita en staffordshire terrier americano (CMD-AST)
- American Staffordshire Terrier
🧬 Interpretation of genotypes CMD-AST
Genotipo
Estado
🟡 N/N
No transportista: sin riesgo
🟡 N/CMD-AST
Transportista: sin riesgo
❌ CMD-AST/CMD-AST
Afectados - En Riesgo
Preguntas frecuentes: comprender la interpretación
¿Un “transportista” es serio?
No. El animal generalmente está sano pero puede transmitir la mutación a su descendencia.
¿Qué pasa si un animal está “afectado”?
Lleva dos copias mutadas. Se esperan signos clínicos dependiendo de la enfermedad. No se debe criar.
¿Por qué hay diferencias entre hombre/mujer?
Algunas enfermedades están ligadas al sexo, por lo que su expresión varía dependiendo del sexo del animal.
Predecir la descendencia
N/N (no-transportista)
N/CMD-AST (Transportista)
CMD-AST/CMD-AST (Afectado)
Preguntas frecuentes sobre la prueba de ADN
¿Qué detecta esta prueba de ADN?
This DNA test detects the mutation associated with Congenital Muscular Dystrophy In American Staffordshire Terrier (CMD-AST) in order to identify clear, carrier, or at-risk animals.
¿Por qué probar un animal reproductor?
Las pruebas de ADN ayudan a los criadores a planificar apareamientos más seguros y reducir el riesgo de transmitir la mutación a la descendencia.
¿Cuál es el modo de herencia de esta prueba?
El modo de herencia informado para esta prueba es autosómico recesivo.
¿Qué mutación se analiza en esta prueba?
This test analyses the mutation COL6A3 c.6398del.
¿Un animal portador está necesariamente afectado?
No necesariamente. La interpretación depende del patrón de herencia y del genotipo resultante.
Referencias
Jankelunas Leanne, Murthy Vishal D, Chen Annie V, Minor Katie M, Friedenberg Steven G, Cullen Jonah N, Guo Ling T, Mickelson James R, Shelton G Diane. Novel COL6A3 frameshift variant in American Staffordshire Terrier dogs with Ullrich-like congenital muscular dystrophy. J Vet Intern Med. 2023 Nov-Dec;37(6):2504-2509. doi: 10.1111/jvim.16862. Epub 2023 Sep 14.