What does “Clear” mean?
The animal does not carry the mutation. It will not develop the disease and will not pass it on.
Cat Primary Hyperoxaluria Type Ii (Oxalosis Ii) (PH2)
Primary Hyperoxaluria Type II (PH2) in cats is a rare genetic disorder causing excessive oxalate buildup, leading to kidney stones and renal failure. Early DNA testing for PH2 helps identify affected cats, enabling timely intervention and better management. This hereditary condition results from mutations in the GRHPR gene, crucial for oxalate metabolism. Breeders and veterinarians rely on DNA tests to prevent passing PH2 to future generations. Accurate diagnosis through genetic screening improves treatment outcomes and quality of life for cats. If you suspect PH2 symptoms like urinary issues or lethargy, consult your vet for DNA testing. Prioritizing genetic health ensures your cat’s long-term wellness and vitality.
Abbreviation : PH2
Analysed mutation : GRHPR
Inheritance : Autosomal Recessive
Acronym
PH2
Observed frequency
Clinical severity
Clinical classification
Metabolic Diseases
Analysed mutation
GRHPR
p.(N169Kfs*46)
p.(N169Kfs*46)
Mode of inheritance
Autosomal Recessive
Test summary:
Primary Hyperoxaluria Type II (PH2) in cats is a rare genetic disorder causing excessive oxalate production. This leads to the formation of calcium oxalate crystals, which can accumulate in the kidneys and urinary tract. A DNA test can identify mutations responsible for PH2, enabling early diagnosis. Early detection helps manage symptoms and prevent severe kidney damage. Genetic testing is crucial for breeders to reduce the risk of passing PH2 to offspring.
Available from the pack : Basic
This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.
View DNA Test Packs →Choose the pack that best fits your breeding or health strategy of your animals.
Introduction to Primary Hyperoxaluria Type II (PH2)
Primary Hyperoxaluria Type II (PH2), also known as Oxalosis II, is a rare genetic disorder that affects the metabolism of oxalate in the body. This condition is caused by a deficiency of the enzyme glycolate oxidase, which is responsible for the conversion of glycolate into oxalate. When this enzyme is deficient, glycolate accumulates and is subsequently converted into oxalate in excess, leading to hyperoxaluria or elevated levels of oxalate in the urine.
Clinical Signs and Symptoms
In cats, PH2 can present with a variety of clinical signs that can significantly affect their quality of life. Common symptoms include the formation of calcium oxalate crystals or stones in the urinary tract, which can lead to urinary obstruction and painful urination. Other signs may include increased thirst and urination, vomiting, and, in severe cases, kidney damage or failure due to the accumulation of oxalate in the kidneys.
Diagnosis of Primary Hyperoxaluria Type II
The diagnosis of PH2 is typically made through a combination of clinical signs, urine analysis, and genetic testing. Urine tests often reveal elevated levels of oxalate, which can be a strong indicator of the condition. However, the definitive diagnosis is usually confirmed through DNA testing that identifies mutations in the relevant genes associated with PH2.
Management and Treatment
Management of Primary Hyperoxaluria Type II in cats primarily focuses on reducing the levels of oxalate in the body and alleviating symptoms. This may include dietary modifications to limit oxalate intake, increased hydration to help dilute urine, and medications to manage pain or inflammation. In cases of severe kidney damage or recurrent urinary obstruction, surgical intervention may be necessary.
Conclusion
Primary Hyperoxaluria Type II is a serious genetic condition that can have significant health implications for affected cats. Early diagnosis and management are critical in improving outcomes and quality of life for these animals. Genetic testing plays an essential role in confirming the diagnosis, allowing for timely intervention and care tailored to the specific needs of the cat.
Breed recognized for the test : Primary Hyperoxaluria Type Ii (Oxalosis Ii) (PH2)
- Abyssinian
- Aegean
- Alpine Lynx
- Altai
- American Bobtail
- American Bobtail Longhair
- American Bobtail Shorthair
- American Burmese
- American Curl
- American Curl Longhair
- American Curl Shorthair
- American Fold Longhair
- American Fold Shorthair
- American Keuda
- American Longhair
- American Lynx
- American Miniature Cat
- American Polydactyl
- American Ringtail
- American Shorthair
- American Straight Long Hair
- American Straight Shorthair
- American Wirehair
- Anatoli
- Aphrodite
- Aphrodite Giant
- Aphrodite's Giant Longhair
- Aphrodite's Giant Shorthair
- Arabian Mau
- Asian
- Asian Leopard Cat
- Asian Longhair
- Asian Semi-longhair
- Asian Shorthair
- Australian Bombay
- Australian Mist
- Aztec
- Balinese
- Bambino
- Bambino Curl
- BamBob
- Bengal
- Bengal Longhair
- Birman
- Bobcat
- Bohemian Rex
- Bombay
- Bramble
- Brazilian Shorthair
- Bristol
- British Ice Longhair
- British Ice Shorthair
- British Longhair
- British Shorthair
- Burmese
- Burmese European
- Burmese Longhair
- Burmilla
- Burmilla Longhair
- Burmilla Shorthair
- California Spangled
- California Toyger
- Californian Rex
- Canadian Feral Cat
- Canadian Sphynx
- Caracal
- Celtic
- Celtic Shorthair
- Ceylon
- Chantilly-Tiffany
- Chartreux
- Chausie
- Chinchilla Longhair
- Chinese Harlequin
- Chinese Li Hua
- Chinese Tank Cat
- Classicat
- Colorpoint Shorthair
- Companion Cat
- Copper
- Cornish Rex
- Cornish Rex Longhair
- Curly Tail Cat
- Cymric
- Cyprus
- Desert Lynx
- Deutsch Langhaar
- Devon Rex
- Domestic Longhair
- Domestic medium-haired
- Domestic Shorthair
- Don Sphynx
- Donskoy
- Dossow
- Dragon Li
- Dwelf
- Egyptian Mau
- Elf
- European
- European Burmese
- European Shorthair
- Exotic
- Exotic Shorthair
- Experimental
- Fishing Cat
- Foldex
- Foreign White
- Foreign White Longhair
- Foreign White Shorthair
- Gao Taem
- Genetta
- Geoffroy's Cat
- German Longhair
- German Rex
- Havana
- Havana Brown
- Hemingway Curl
- Hibernian Lynx
- Highland Fold
- Highland Lynx
- Highland Straight
- Highlander
- Highlander Longhair
- Highlander Shorthair
- Himalayan
- House Cat Longhair
- House Cat Shorthair
- Household Pet
- Household Pet Kitten
- Household Pet Longhair
- Household Pet Shorthair
- Isle of Man Longhair
- Isle of Man Shorthair
- Jaguarette
- Jaguarundi Curl
- Japanese Bobtail
- Japanese Bobtail Longhair
- Japanese Bobtail Shorthair
- Japanese domestic
- Javanese
- Jungala
- Jungle Cat
- Jungle Curl
- Jungle Lynx
- Junglebob
- Kanaani
- Karelian Bobtail
- Karelian Bobtail Longhair
- Khao Manee
- Khaomanee
- Kinkalow
- Korat
- Korean Bobtail
- Korn Ja
- Kurilian Bobtail
- Kurilian Bobtail Longhair
- Kurilian Bobtail Shorthair
- Lambkin
- LaPerm
- LaPerm Longhair
- LaPerm Shorthair
- Lykoi
- Maine Coon
- Maine Coon Polydactyl
- Manx
- Manx Longhair
- Manx Shorthair
- Me-kong Bobtail
- Meerkat
- Mekong Bobtail
- Minskin
- Minuet
- Minuet Longhair
- Mixed Breed
- Mohave Bob
- Mojave Spotted
- Mokave Jag Cat
- Mountain Bob
- Munchkin
- Munchkin Longhair
- Napoleon
- Nebelung
- Neva Masquerade
- Niebelung
- Non Recognized Hairless
- Non Recognized Longhair
- Non Recognized Shorthair
- Norwegian Forest Cat
- Ocicat
- Ojos Azules
- Oregon Rex (extinct)
- Oriental
- Oriental Bicolor
- Oriental Longhair
- Oriental Shorthair
- Original Longhair
- Owyhee Bob
- Pantherette
- Persian
- Peterbald
- Pharaoh
- Pixiebob
- Pixiebob Longhair
- Puppykat
- Raas
- Ragamuffin
- Ragdoll
- Ruffle
- Russian
- Russian Black
- Russian Blue
- Russian Tabby
- Russian White
- Rusty Spotted Cat
- Sacred Birman
- Safari
- Sam Sawet
- Sashkin Rex
- Savannah
- Scottish Fold
- Scottish Fold Longhair
- Scottish Longhair
- Scottish Shorthair
- Scottish Straight
- Scottish Straight Longhair
- Selkirk Rex
- Selkirk Rex Longhair
- Selkirk Rex Shorthair
- Selkirk Straight
- Serengeti
- Serrade Petit
- Serval
- Siamese
- Siamese Longhair
- Siberian
- Singapura
- Skookum
- Snowbob
- Snowshoe
- Sokoke
- Somali
- Sphynx
- Suffolk
- Suphalak
- Tennessee Bobtail
- Tennessee Rex
- Thai
- Thai Blue Point
- Thai Lilac
- Thai Lilac Point
- Tiffanie
- Tigrette
- Tonkinese
- Tonkinese Longhair
- Tonkinese Shorthair
- Toybob
- Toyger
- Traditional Siamese
- Transylvanian
- Tundra
- Turkish Angora
- Turkish Van
- Turkish Vankedisi
- Ukrainian Levkoy
- Unknown
- Ural Rex
- Ural Rex Longhair
- Vienna Woods
- Viverral
- York Chocolate
🧬 Interpretation of genotypes PH2
Genotype
Status
🟡 N/N
Non-carrier - No Risk
🟡 N/PH2
Carrier - No Risk
❌ PH2/PH2
Affected - At Risk
FAQ: understanding the interpretation
Is a “Carrier” serious?
No. The animal is generally healthy but can transmit the mutation to its offspring.
What if an animal is “Affected”?
It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.
Why are there differences between male / female?
Some diseases are sex-linked, so their expression varies depending on the animal’s sex.
Predict Offspring
N/N (Non-carrier)
N/PH2 (Carrier)
PH2/PH2 (Affected)
DNA Test FAQ
What does this DNA test detect?
This DNA test detects the mutation associated with Primary Hyperoxaluria Type Ii (Oxalosis Ii) (PH2) in order to identify clear, carrier, or at-risk animals.
Why test a breeding animal?
DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.
What is the inheritance mode of this test?
The inheritance mode reported for this test is Autosomal Recessive.
Which mutation is analysed in this test?
This test analyses the mutation GRHPR.
Is a carrier animal necessarily affected?
Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.