Dog Cerebellar Cortical Degeneration (CCD)

Cerebellar Cortical Degeneration (CCD) is a hereditary neurological condition in dogs that affects balance and coordination. A DNA test for CCD can help identify carriers and affected dogs, allowing pet owners to make informed breeding decisions. Early detection through genetic testing is crucial for managing symptoms and improving a dog's quality of life. This simple test can provide peace of mind and help prevent the spread of this condition in breeds prone to CCD. By understanding your dog's genetic profile, you can take proactive steps to ensure their health and well-being. Invest in a DNA test today to safeguard your furry friend's future. Stay informed about CCD and take action for your dog's health!

Abbreviation : CCD

Analysed mutation : SNX14 c.26531G>A

Inheritance : Autosomal Recessive

Acronym

CCD

Observed frequency

Rare

Clinical severity

Severe

Clinical classification

Neurological Diseases

Analysed mutation

SNX14 c.26531G>A

Mode of inheritance

Autosomal Recessive (Complete)

Test summary:

Cerebellar Cortical Degeneration (CCD) is a genetic condition affecting dogs, leading to progressive loss of coordination and balance. A DNA test can identify carriers of the gene responsible for this disorder, allowing breeders to make informed decisions. Early detection through testing can help manage the symptoms and improve the quality of life for affected dogs. Pet owners can take proactive measures by seeking genetic counseling and regular veterinary check-ups. Ultimately, the DNA test plays a crucial role in the responsible breeding and health management of canine companions.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Understanding Cerebellar Cortical Degeneration (CCD) in Dogs

Cerebellar Cortical Degeneration (CCD) is a progressive neurological condition that affects the cerebellum, a part of the brain responsible for coordinating voluntary movements, balance, and posture. This condition is characterized by the degeneration of the neurons in the cerebellar cortex, leading to a range of motor dysfunctions that can severely impact a dog's quality of life.

Symptoms of CCD

The clinical signs of CCD typically manifest as a lack of coordination, unsteady gait, and difficulty performing everyday movements. Affected dogs may exhibit symptoms such as tremors, a wide-based stance, and difficulty with tasks that require precise motor control, such as jumping or navigating stairs. As the disease progresses, these symptoms can become more pronounced, leading to significant mobility challenges.

Causes and Pathophysiology

The exact cause of CCD is not fully understood, but it is believed to be associated with genetic factors that influence neuronal health and maintenance in the cerebellum. In some cases, oxidative stress and other cellular mechanisms may contribute to the degeneration of neurons, leading to the clinical signs observed in affected dogs. Research into the genetic underpinnings of this condition is ongoing, with the aim of identifying specific mutations that may predispose certain dogs to CCD.

Diagnosis of CCD

Diagnosis of CCD typically involves a combination of clinical neurological examination and imaging techniques. While a definitive diagnosis may be made through advanced imaging such as MRI, genetic testing can also play a crucial role in identifying dogs at risk for developing this condition. The identification of specific genetic markers associated with CCD can aid in understanding the disease's prevalence and potential management options.

Management and Treatment Options

Currently, there is no cure for Cerebellar Cortical Degeneration in dogs. Management strategies focus on improving the quality of life for affected animals. This may include physical therapy to enhance mobility, dietary adjustments to support overall health, and environmental modifications to ensure a safe living space. Caretakers are encouraged to work closely with veterinarians to develop a tailored management plan that addresses the specific needs of the affected dog.

Conclusion

Cerebellar Cortical Degeneration is a challenging condition that can significantly affect a dog’s motor functions and overall well-being. Understanding the symptoms, causes, and management strategies is essential for pet owners and veterinarians alike. Continued research into the genetic aspects of CCD may pave the way for better diagnostic tools and potential therapeutic approaches in the future.

Breed recognized for the test : Cerebellar Cortical Degeneration (CCD)

Vizsla
Wirehaired Vizsla

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes CCD

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/CCD

Carrier - No Risk

❌ CCD/CCD

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/CCD (Carrier)

CCD/CCD (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Cerebellar Cortical Degeneration (CCD) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation SNX14 c.26531G>A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Fenn Joe, Boursnell Mike, Hitti Rebekkah J, Jenkins Christopher A, Terry Rebecca L, Priestnall Simon L, Kenny Patrick J, Mellersh Cathryn S, Forman Oliver P. Genome sequencing reveals a splice donor site mutation in the SNX14 gene associated with a novel cerebellar cortical degeneration in the Hungarian Vizsla dog breed. BMC Genet. 2016 Aug 26;17(1):123. doi: 10.1186/s12863-016-0433-y.

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