Dog Cardiac Laminopathy (CLAM)

Discover the importance of the Cardiac Laminopathy (CLAM) DNA test for dogs, a vital tool in identifying genetic predisposition to heart disease. This test helps breeders and pet owners detect mutations linked to cardiac laminopathy, ensuring early intervention and better management. By screening your dog’s DNA, you can prevent the spread of this hereditary condition and promote healthier breeding practices. The CLAM test is quick, accurate, and essential for maintaining your dog’s heart health. Protect your furry friend with reliable genetic testing today. Stay informed and proactive with the Cardiac Laminopathy DNA test for dogs.

Abbreviation : CLAM

Analysed mutation : LMNA c.1726del

Inheritance : Autosomal Dominant

Acronym

CLAM

Observed frequency

Rare

Clinical severity

Mild

Clinical classification

Cardiovascular Diseases

Analysed mutation

LMNA c.1726del
p.(D576Tfs*124)

Mode of inheritance

Autosomal Dominant

Test summary:

The DNA test for Cardiac Laminopathy (CLAM) in dogs helps identify genetic mutations linked to this inherited heart condition. CLAM affects the heart's electrical system, potentially leading to arrhythmias and heart failure. Early detection through genetic testing allows breeders and veterinarians to make informed decisions to reduce the risk of passing the disease. This test is especially important for breeds known to be predisposed to cardiac laminopathy. Overall, DNA testing supports healthier breeding practices and improved canine cardiac care.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Choose the pack that best fits your breeding or health strategy of your animals.

Introduction to Cardiac Laminopathy (CLAM)

Cardiac Laminopathy (CLAM) is a genetic condition that affects the heart muscle in dogs, leading to various cardiac issues. It is primarily caused by mutations in the genes responsible for the structural integrity of cardiac cells. This condition can result in arrhythmias, heart failure, and other serious cardiovascular problems, significantly impacting the health and longevity of affected dogs.

Understanding the Genetic Basis

The underlying genetic mutations associated with CLAM disrupt the normal function of lamin proteins, which are crucial for maintaining the structural framework of cardiac cells. These proteins play an essential role in the stability of the heart muscle and its ability to function effectively. When mutations occur, they can lead to a weakened heart structure, making it more susceptible to damage and dysfunction.

Clinical Signs and Symptoms

Dogs with Cardiac Laminopathy may exhibit a range of clinical signs, which can vary in severity. Common symptoms include exercise intolerance, lethargy, coughing, and episodes of fainting or collapse. As the condition progresses, more severe manifestations, such as congestive heart failure or sudden cardiac events, may occur. Early detection and monitoring are crucial to managing the condition effectively.

Importance of DNA Testing

DNA testing for Cardiac Laminopathy plays a vital role in identifying at-risk dogs and making informed breeding decisions. By testing for the specific genetic mutations associated with CLAM, breeders and pet owners can better understand the risk of this condition in their dogs. This proactive approach can help reduce the prevalence of CLAM in future generations and improve overall canine heart health.

Management and Treatment Options

While there is currently no cure for Cardiac Laminopathy, management strategies can help mitigate the condition's effects. Treatment options may include medications to manage arrhythmias, dietary changes, and lifestyle modifications to reduce stress on the heart. Regular veterinary check-ups and monitoring are essential to assess the progression of the disease and adjust treatment plans as necessary.

Conclusion

Cardiac Laminopathy is a serious genetic condition that poses significant challenges for affected dogs and their owners. Understanding the genetic basis, recognizing clinical signs, and utilizing DNA testing are crucial steps in managing this condition. With proper care and attention, dogs with CLAM can lead fulfilling lives, and ongoing research may further enhance our understanding and treatment of this cardiac disorder.

Breed recognized for the test : Cardiac Laminopathy (CLAM)

Nova Scotia Duck Tolling Retriever

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes CLAM

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/CLAM

Carrier - At Risk

❌ CLAM/CLAM

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/CLAM (Carrier)

CLAM/CLAM (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Cardiac Laminopathy (CLAM) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Dominant.

Which mutation is analysed in this test?

This test analyses the mutation LMNA c.1726del.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Bannasch Danika L, Oertle Danielle T, Vo Julia, Batcher Kevin L, Stern Joshua A, Kaplan Joanna L, Li Ronald H L, Madden Indiana E, Christen Matthias, Leeb Tosso, Joshi Nikhil. Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever. Sci Rep. 2023 Nov 4;13(1):19077. doi: 10.1038/s41598-023-46601-2.

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