Què significa "Esborrar"?
L'animal no porta la mutació. No desenvoluparà la malaltia i no ho transmetrà.
gos Glaucoma primari d'angle obert a Basset Fauve De Bretagne (POAG-BFB)
Discover the importance of DNA testing for Primary Open Angle Glaucoma (POAG) in Basset Fauve de Bretagne dogs. This hereditary condition can lead to serious vision problems, making early detection crucial. By utilizing a DNA test, breeders and pet owners can identify at-risk individuals and implement preventive measures. Understanding your dog’s genetic predisposition allows for better health management and informed breeding decisions. Ensure the long-term well-being of your Basset Fauve de Bretagne by considering a genetic test for POAG. Protect your furry friend’s vision and quality of life today! Explore reliable testing options to stay ahead of this genetic condition.
Abreviatura: POAG-BFB
Mutació analitzada: ADAMTS17 c.1552G>A
Herència: Autosòmic recessiu
Acrònim
POAG-BFB
Freqüència observada
Gravetat clínica
Classificació clínica
Malalties Oftàlmiques
Mutació analitzada
ADAMTS17 c.1552G>A
p.(G518S)
p.(G518S)
Modalitat d'herència
Autosòmic recessiu
Resum de la prova:
The DNA test for Primary Open Angle Glaucoma (POAG) in Basset Fauve de Bretagne is a crucial tool for breeders and veterinarians. This genetic test helps identify dogs at risk of developing this progressive eye condition, which can lead to vision loss. By screening for specific genetic markers, responsible breeding practices can be implemented to reduce the incidence of POAG in future generations. Early detection through DNA testing allows for timely interventions, improving the quality of life for affected dogs. Ultimately, this test contributes to the overall health and longevity of the breed.
Disponible des del pack: Basic
Aquesta prova d'ADN s'inclou a partir del nostre pack Basic — i també forma part dels packs Basic, Standard, Advanced, Complete.
Veure paquets de proves d'ADN →Tria el paquet que millor s'adapti a la teva estratègia de cria o salut dels teus animals.
Understanding Primary Open Angle Glaucoma (POAG) in Basset Fauve De Bretagne
Primary Open Angle Glaucoma (POAG) is a significant ocular condition that affects the intraocular pressure in dogs, particularly noted in breeds like the Basset Fauve De Bretagne. This condition is characterized by a gradual increase in intraocular pressure due to impaired drainage of aqueous humor, leading to potential optic nerve damage and vision loss if not addressed promptly.
Genetic Basis of POAG
Research has indicated that there is a hereditary component to POAG, suggesting that certain genetic mutations may predispose individuals to developing this condition. The identification of specific genetic markers associated with POAG can assist breeders in making informed decisions to reduce the prevalence of this glaucoma type within the breed.
Clinical Signs and Diagnosis
The clinical signs of POAG can be subtle at first, often including increased tear production, cloudiness of the cornea, and behavioral changes such as reluctance to engage in activities that require good vision. As the condition progresses, dogs may exhibit signs of pain, such as squinting or rubbing their eyes. Early diagnosis is crucial for effective management and to prevent irreversible damage to the optic nerve.
Opcions de tractament
Treatment for POAG typically involves a combination of medical management and surgical intervention. Medications may be prescribed to lower intraocular pressure, while surgical options can include procedures to improve fluid drainage from the eye. The choice of treatment depends on the severity of the condition and the individual dog's needs.
Importància de les proves genètiques
Genetic testing for POAG in Basset Fauve De Bretagne serves as a crucial tool for responsible breeding practices. By identifying carriers of the genetic mutations associated with POAG, breeders can make informed breeding choices that may help reduce the incidence of this condition within the breed. This proactive approach contributes to the overall health and well-being of future generations of Basset Fauve De Bretagne dogs.
Conclusió
Primary Open Angle Glaucoma is a serious condition that can lead to significant health issues if left untreated. Understanding the genetic factors involved in this disease, along with the clinical signs and treatment options, is essential for dog owners and breeders alike. Through genetic testing and responsible breeding practices, the impact of POAG can be mitigated, leading to healthier lives for affected breeds.
Raça reconeguda per a la prova: Glaucoma primari d'angle obert a Basset Fauve De Bretagne (POAG-BFB)
- Basset Fauve de Bretagne
🧬 Interpretation of genotypes POAG-BFB
Genotip
Estat
🟡 N/N
No transportista - Sense risc
🟡 N/POAG-BFB
Transportista - Sense risc
❌ POAG-BFB/POAG-BFB
Afectat - En risc
Preguntes freqüents: entendre la interpretació
Un "Transportista" és seriós?
No. L'animal és generalment sa, però pot transmetre la mutació al seu descendència.
Què passa si un animal està "afectat"?
Porta dues còpies mutades. S'esperen signes clínics segons la malaltia. No s'ha de criar.
Per què hi ha diferències entre home/dona?
Algunes malalties estan lligades al sexe, de manera que la seva expressió varia en funció de la sexe de l'animal.
Prediu la descendència
N/N (no-transportista)
N/POAG-BFB (Portador)
POAG-BFB/POAG-BFB (Afectat)
Preguntes freqüents sobre les proves d'ADN
Què detecta aquesta prova d'ADN?
This DNA test detects the mutation associated with Primary Open Angle Glaucoma In Basset Fauve De Bretagne (POAG) in order to identify clear, carrier, or at-risk animals.
Per què provar un animal reproductor?
Les proves d'ADN ajuden els criadors a planificar aparellaments més segurs i reduir el risc de transmetre la mutació a la descendència.
Quina és la manera d'herència d'aquesta prova?
El mode d'herència informat per a aquesta prova és autosòmic recessiu.
Quina mutació s'analitza en aquesta prova?
This test analyses the mutation ADAMTS17 c.1552G>A.
Un animal portador està necessàriament afectat?
No necessàriament. La interpretació depèn del patró d'herència i del genotip resultant.
Referències
Oliver James A C, Forman Oliver P, Pettitt Louise, Mellersh Cathryn S. Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One. 2015 Oct 16;10(10):e0140436. doi: 10.1371/journal.pone.0140436. eCollection 2015.