Dog May-Hegglin Anomaly (MHA)

Discover the importance of the DNA test for May-Hegglin Anomaly (MHA) in dogs, a rare genetic disorder affecting platelet function and blood clotting. Early detection through this test helps breeders and veterinarians identify carriers and affected dogs, ensuring responsible breeding practices. By screening for MHA, pet owners can prevent the transmission of this condition and safeguard their dog's health. Our accurate and reliable DNA test provides fast results, supporting better management and treatment plans. Protect your dog’s well-being with the May-Hegglin Anomaly DNA test today. Stay informed and keep your furry friend healthy with our expert genetic testing services.

Abbreviation : MHA

Analysed mutation : MYH9 c.5521G>A

Inheritance : Autosomal Dominant

Acronym

MHA

Observed frequency

Rare

Clinical severity

Moderate

Clinical classification

Haematological Diseases

Analysed mutation

MYH9 c.5521G>A
p.(E1841L)

Mode of inheritance

Autosomal Dominant

Test summary:

May-Hegglin Anomaly (MHA) is a rare genetic disorder affecting dogs, characterized by abnormal platelet size and reduced platelet count. A DNA test can identify mutations in the MYH9 gene responsible for this condition. Early diagnosis through genetic testing helps manage bleeding risks and informs breeding decisions. Dogs with MHA may show mild bleeding tendencies but often live normal lives with proper care. DNA testing is essential for preventing the spread of this anomaly in dog populations.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Introduction to May-Hegglin Anomaly (MHA)

May-Hegglin Anomaly (MHA) is a rare genetic blood disorder characterized primarily by the presence of large platelets and a reduction in the number of platelets in the bloodstream, a condition known as thrombocytopenia. This anomaly may result in various clinical symptoms, including easy bruising, prolonged bleeding, and an increased risk of bleeding complications.

Genetic Basis of MHA

MHA is linked to mutations in the MYH9 gene, which encodes a protein involved in the structure and function of cells, particularly in the cytoskeletal organization of platelets. These mutations can lead to the production of abnormal platelets, which are larger than normal and often dysfunctional. The condition can also affect other cell types, potentially impacting kidney function and hearing.

Clinical Signs and Symptoms

Dogs affected by May-Hegglin Anomaly may exhibit clinical signs that can vary in severity. Common symptoms include bruising, nosebleeds, and bleeding gums. Some dogs may also experience prolonged bleeding after surgery or injury. In severe cases, spontaneous bleeding may occur, posing significant health risks. It is important for pet owners to monitor their dogs for these signs and consult with a veterinarian if they suspect a bleeding disorder.

Diagnosis of MHA

The diagnosis of May-Hegglin Anomaly typically involves a combination of clinical evaluation, blood tests, and genetic testing. A complete blood count (CBC) may reveal thrombocytopenia and the presence of large platelets, which are hallmark features of the condition. Genetic testing can confirm the presence of mutations in the MYH9 gene, providing a definitive diagnosis.

Management and Treatment

While there is no cure for May-Hegglin Anomaly, management strategies focus on minimizing the risk of bleeding and managing symptoms. This may include regular monitoring of platelet counts, avoiding medications that can exacerbate bleeding risks, and providing supportive care during episodes of bleeding. In some cases, veterinary intervention may be necessary to address significant bleeding events or complications.

Conclusion

May-Hegglin Anomaly is a genetic disorder that affects platelet function in dogs, leading to various bleeding complications. Understanding the condition, its symptoms, and management strategies is crucial for pet owners and veterinarians alike. Genetic testing plays a vital role in confirming the diagnosis and facilitating appropriate care for affected dogs.

Breed recognized for the test : May-Hegglin Anomaly (MHA)

Carlin Pinscher
Pug

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes MHA

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/MHA

Carrier - At Risk

❌ MHA/MHA

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/MHA (Carrier)

MHA/MHA (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with May-Hegglin Anomaly (MHA) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Dominant.

Which mutation is analysed in this test?

This test analyses the mutation MYH9 c.5521G>A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Flatland Bente, Fry Michael M, Baek Seung J, Bahn Jae H, LeBlanc Casey J, Dunlap John R, Carroll Roger C, Kosiba Deborah J, Millsaps Doris J, Schleis Stephanie E. May-Hegglin anomaly in a dog. Vet Clin Pathol. 2011 Jun;40(2):207-14. doi: 10.1111/j.1939-165X.2011.00320.x. Epub 2011 May 9.

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