Dog Leonberger Polyneuropathy 1 (LPN1)

The Leonberger Polyneuropathy 1 (LPN1) DNA test is essential for responsible breeders and dog owners to detect this inherited neurological disorder early. LPN1 affects the peripheral nerves, leading to muscle weakness and mobility issues in Leonberger dogs. By using the LPN1 DNA test, you can identify carriers and affected dogs, helping to prevent the spread of this debilitating condition. Early diagnosis through genetic testing supports better health management and breeding decisions. This test is simple, accurate, and vital for maintaining the Leonberger breed’s overall health. Protect your dog’s future by choosing LPN1 DNA testing today. Stay informed and promote responsible Leonberger breeding practices.

Abbreviation : LPN1

Analysed mutation : ARHGEF10 c.1955_1958+6del

Inheritance : Autosomal Dominant

Acronym

LPN1

Observed frequency

Rare

Clinical severity

Severe

Clinical classification

Neurological Diseases

Analysed mutation

ARHGEF10 c.1955_1958+6del

Mode of inheritance

Autosomal Dominant (Complete)

Test summary:

The DNA test for Leonberger Polyneuropathy 1 (LPN1) in dogs helps identify carriers and affected individuals of this inherited neurological disorder. LPN1 causes progressive nerve damage, leading to muscle weakness and loss of coordination. Early detection through genetic testing allows breeders to make informed decisions and reduce the incidence of the disease. This test is especially important for Leonberger dogs, where LPN1 is more prevalent. Responsible breeding based on test results promotes healthier future generations.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Understanding Leonberger Polyneuropathy 1 (LPN1)

Leonberger Polyneuropathy 1 (LPN1) is a hereditary neurological disorder that primarily affects the Leonberger breed. This condition is characterized by a progressive degeneration of the peripheral nerves, leading to a range of clinical symptoms that can significantly impact the quality of life for affected dogs. LPN1 is caused by a mutation in the gene responsible for the production of proteins essential for nerve function.

Clinical Symptoms of LPN1

The symptoms of LPN1 typically manifest between 6 months and 3 years of age, although they can vary widely in severity and onset. Common clinical signs include difficulty in walking, hind limb weakness, decreased reflexes, and tremors. As the disease progresses, dogs may exhibit signs of pain, difficulty in coordination, and, in severe cases, paralysis. Early recognition of these symptoms is crucial for management and treatment options.

Pathophysiology of LPN1

The underlying pathology of LPN1 involves the demyelination of peripheral nerves. Myelin is the protective sheath that surrounds nerve fibers, allowing for efficient transmission of electrical signals. In LPN1, the mutation disrupts the normal production and maintenance of myelin, leading to impaired nerve function. This demyelination results in the symptoms observed in affected dogs, as the nerves become less capable of transmitting signals effectively.

Diagnosis of LPN1

Diagnosis of LPN1 typically involves a combination of clinical evaluation and genetic testing. Veterinarians will assess the dog's clinical signs and may suggest a DNA test to confirm the presence of the mutation associated with LPN1. This genetic testing plays a vital role in identifying carriers and affected dogs, aiding breeders in making informed decisions to reduce the incidence of this condition within the breed.

Management and Care for Affected Dogs

Currently, there is no cure for LPN1, and management focuses on improving the quality of life for affected dogs. This may include physical therapy, pain management, and supportive care to help maintain mobility and comfort. Regular veterinary check-ups are essential to monitor the progression of the disease and adjust care plans accordingly. Owners are encouraged to provide a safe and comfortable environment for their dogs to minimize the risks associated with mobility issues.

Conclusion

Leonberger Polyneuropathy 1 (LPN1) is a serious condition that poses significant challenges for affected dogs and their owners. Understanding the nature of this disorder, its symptoms, and management strategies is critical for ensuring the best possible quality of life for affected individuals. Ongoing research and genetic testing continue to play an important role in addressing LPN1 within the Leonberger breed, promoting healthier futures for these beloved dogs.

Breed recognized for the test : Leonberger Polyneuropathy 1 (LPN1)

Leonberger
Saint Bernard

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes LPN1

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/LPN1

Carrier - At Risk

❌ LPN1/LPN1

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/LPN1 (Carrier)

LPN1/LPN1 (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Leonberger Polyneuropathy 1 (LPN1) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Dominant.

Which mutation is analysed in this test?

This test analyses the mutation ARHGEF10 c.1955_1958+6del.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Ekenstedt Kari J, Becker Doreen, Minor Katie M, Shelton G Diane, Patterson Edward E, Bley Tim, Oevermann Anna, Bilzer Thomas, Leeb Tosso, Drögemüller Cord, Mickelson James R. An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs. PLoS Genet. 2014 Oct 2;10(10):e1004635. doi: 10.1371/journal.pgen.1004635. eCollection 2014 Oct.

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