Dog Deafness With Vestibular Dysfunction Variant 2 (DINGS2)

Uncovering the genetic basis of canine health is essential for dog owners, especially when it comes to conditions like Deafness With Vestibular Dysfunction Variant 2 (DINGS). This DNA test identifies dogs at risk of developing DINGS, providing valuable insights for breeders and pet owners. Early detection through genetic testing can lead to proactive management and improved quality of life for affected dogs. By understanding this hereditary condition, you can make informed decisions about breeding and care. Ensure your furry friend’s well-being with the DINGS DNA test, promoting a healthier future. Stay ahead of potential health issues and protect your dog's hearing and balance with this essential genetic screening. Invest in your pet's health today!

Abbreviation : DINGS2

Analysed mutation : MYO7A c.3719G>A

Inheritance : Unknown

Acronym

DINGS2

Observed frequency

Rare

Clinical severity

Moderate

Clinical classification

Ophthalmic Diseases

Analysed mutation

MYO7A c.3719G>A
p.(R1240Q)

Mode of inheritance

Unknown

Test summary:

The DNA test for Deafness With Vestibular Dysfunction Variant 2 (DINGS) in dogs identifies a genetic mutation associated with hearing loss and balance issues. This condition primarily affects certain breeds, leading to challenges in communication and mobility. Early detection through genetic testing can help breeders make informed decisions and reduce the prevalence of DINGS in future generations. Owners of affected dogs can benefit from tailored training and management strategies. Understanding this condition is vital for improving the quality of life for dogs with DINGS.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Overview of Deafness With Vestibular Dysfunction Variant 2 (DINGS)

Deafness With Vestibular Dysfunction Variant 2 (DINGS) is a hereditary condition observed in dogs, characterized by a combination of hearing impairment and balance disorders. This condition is caused by genetic mutations that affect the inner ear structures responsible for hearing and maintaining equilibrium. Understanding DINGS is crucial for early diagnosis and management, allowing affected dogs to receive appropriate care and support.

Genetic Basis of DINGS

The DINGS condition is linked to specific mutations in genes that are integral to the development and function of the auditory and vestibular systems in dogs. These genetic anomalies disrupt the normal functioning of hair cells in the inner ear, leading to progressive hearing loss and vestibular dysfunction, which manifests as issues with balance and coordination.

Symptoms and Clinical Presentation

Dogs affected by DINGS may exhibit a range of symptoms. Common signs include hearing impairment, which may be evident from an early age, as well as vestibular symptoms such as uncoordinated movements, head tilt, circling, and difficulty maintaining balance. Owners may notice that their pets are less responsive to auditory stimuli and may appear clumsy or disoriented when moving about.

Diagnosis of DINGS

Diagnosis of DINGS typically involves a combination of clinical evaluation, behavioral assessments, and genetic testing. Veterinarians may conduct hearing tests, such as brainstem auditory evoked response (BAER) testing, to assess auditory function. Genetic testing can confirm the presence of mutations associated with DINGS, enabling precise identification of the condition.

Management and Care

While there is currently no cure for DINGS, management strategies can help improve the quality of life for affected dogs. These may include environmental modifications to enhance safety and minimize risks associated with balance issues. Training using visual cues and positive reinforcement can also aid in communication, allowing dogs to navigate their surroundings more effectively despite their hearing loss.

Prognosis and Lifelong Considerations

The prognosis for dogs diagnosed with DINGS varies, as the progression of the condition can differ among individuals. While some dogs may adapt well to their disabilities and lead fulfilling lives, others may require ongoing support and adjustments to their living environment. Regular veterinary check-ups are recommended to monitor the condition and address any emerging health issues promptly.

Conclusion

Deafness With Vestibular Dysfunction Variant 2 (DINGS) is a complex genetic condition that significantly impacts a dog's auditory and vestibular functions. Through early diagnosis and appropriate management, owners can help ensure that their pets live comfortably and safely. Continued research into the genetic factors and potential treatments for DINGS will be essential in improving outcomes for affected dogs.

Breed recognized for the test : Deafness With Vestibular Dysfunction Variant 2 (DINGS2)

Doberman Pinscher

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/DINGS2 (Carrier)

DINGS2/DINGS2 (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Deafness With Vestibular Dysfunction Variant 2 (DINGS) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Unknown.

Which mutation is analysed in this test?

This test analyses the mutation MYO7A c.3719G>A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Webb Aubrey A, Ruhe Alison L, Neff Mark W. A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed. Can J Vet Res. 2019 Apr;83(2):142-148.

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