Cat Cystinuria Type I-A (CystIA)

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Cystinuria Type I-A (CystIA) is a genetic condition in cats that affects their ability to metabolize certain amino acids, leading to the formation of kidney stones. A DNA test for CystIA can help cat owners identify carriers and affected individuals, enabling proactive management of this condition. Early detection through genetic testing can significantly improve your cat's quality of life by preventing painful symptoms and costly treatments associated with kidney stones. If you’re a cat owner, consider investing in a Cystinuria DNA test to ensure a healthy future for your feline friend. Understanding CystIA can also guide dietary choices and care strategies tailored to your cat's specific needs. Discover the benefits of genetic testing today to safeguard your pet's health!

Abbreviation : CystIA

Analysed mutation : SLC3A1 c.1342C>T

Inheritance : Autosomal Recessive

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Understanding Cystinuria Type I-A (CystIA) in Cats

Cystinuria Type I-A (CystIA) is a genetic disorder that affects the metabolism of certain amino acids in cats. This condition is characterized by the improper reabsorption of cystine, leading to an increase in urinary cystine levels. As cystine is poorly soluble, its accumulation can result in the formation of urinary stones, also known as uroliths, which can cause discomfort and serious health issues for affected cats.

Symptoms and Clinical Manifestations

Cats with Cystinuria Type I-A may exhibit a range of symptoms related to urinary tract issues. Common signs include frequent urination, straining to urinate, blood in the urine, and possible urinary blockages. These symptoms can cause significant distress and may require immediate veterinary attention. In some cases, cats may also show signs of pain or discomfort in the abdomen, particularly if stones are present.

Diagnosis of Cystinuria Type I-A

The diagnosis of Cystinuria Type I-A typically involves a combination of clinical signs, urine analysis, and genetic testing. Urine analysis can reveal high levels of cystine, while a genetic test can confirm the presence of mutations associated with CystIA. Early diagnosis is crucial for managing the condition effectively and preventing complications such as urinary obstruction or bladder infections.

Treatment Approaches

Management of Cystinuria Type I-A focuses on preventing the formation of urinary stones and alleviating symptoms. Treatment options may include dietary modifications to reduce cystine levels in the urine, increased water intake to dilute the urine, and potentially the use of medications to dissolve existing stones. In severe cases, surgical intervention may be necessary to remove large stones or address urinary blockages.

Prognosis and Management

The prognosis for cats diagnosed with Cystinuria Type I-A can vary depending on the severity of the condition and the effectiveness of the management strategies employed. With proper care and dietary adjustments, many cats can live comfortable lives, although they may require ongoing monitoring and treatment to manage their condition effectively. Regular veterinary check-ups and urine tests are essential to track the health of affected cats.

Conclusion

Cystinuria Type I-A (CystIA) is a significant health concern for affected cats, but with appropriate diagnosis and management, the condition can be effectively controlled. Understanding the symptoms, treatment options, and the importance of regular veterinary care can help cat owners provide the best possible support for their feline companions. Awareness and proactive management are key to ensuring a good quality of life for cats suffering from this genetic disorder.

Breed recognized for the test : Cystinuria Type I-A (CystIA)

• Abyssinian
• Aegean
• Alpine Lynx
• Altai
• American Bobtail
• American Bobtail Longhair
• American Bobtail Shorthair
• American Burmese
• American Curl
• American Curl Longhair
• American Curl Shorthair
• American Fold Longhair
• American Fold Shorthair
• American Keuda
• American Longhair
• American Lynx
• American Miniature Cat
• American Polydactyl
• American Ringtail
• American Shorthair
• American Straight Long Hair
• American Straight Shorthair
• American Wirehair
• Anatoli
• Aphrodite
• Aphrodite Giant
• Aphrodite's Giant Longhair
• Aphrodite's Giant Shorthair
• Arabian Mau
• Asian
• Asian Leopard Cat
• Asian Longhair
• Asian Semi-longhair
• Asian Shorthair
• Australian Bombay
• Australian Mist
• Aztec
• Balinese
• Bambino
• Bambino Curl
• BamBob
• Bengal
• Bengal Longhair
• Birman
• Bobcat
• Bohemian Rex
• Bombay
• Bramble
• Brazilian Shorthair
• Bristol
• British Ice Longhair
• British Ice Shorthair
• British Longhair
• British Shorthair
• Burmese
• Burmese European
• Burmese Longhair
• Burmilla
• Burmilla Longhair
• Burmilla Shorthair
• California Spangled
• California Toyger
• Californian Rex
• Canadian Feral Cat
• Canadian Sphynx
• Caracal
• Celtic
• Celtic Shorthair
• Ceylon
• Chantilly-Tiffany
• Chartreux
• Chausie
• Chinchilla Longhair
• Chinese Harlequin
• Chinese Li Hua
• Chinese Tank Cat
• Classicat
• Colorpoint Shorthair
• Companion Cat
• Copper
• Cornish Rex
• Cornish Rex Longhair
• Curly Tail Cat
• Cymric
• Cyprus
• Desert Lynx
• Deutsch Langhaar
• Devon Rex
• Domestic Longhair
• Domestic medium-haired
• Domestic Shorthair
• Don Sphynx
• Donskoy
• Dossow
• Dragon Li
• Dwelf
• Egyptian Mau
• Elf
• European
• European Burmese
• European Shorthair
• Exotic
• Exotic Shorthair
• Experimental
• Fishing Cat
• Foldex
• Foreign White
• Foreign White Longhair
• Foreign White Shorthair
• Gao Taem
• Genetta
• Geoffroy's Cat
• German Longhair
• German Rex
• Havana
• Havana Brown
• Hemingway Curl
• Hibernian Lynx
• Highland Fold
• Highland Lynx
• Highland Straight
• Highlander
• Highlander Longhair
• Highlander Shorthair
• Himalayan
• House Cat Longhair
• House Cat Shorthair
• Household Pet
• Household Pet Kitten
• Household Pet Longhair
• Household Pet Shorthair
• Isle of Man Longhair
• Isle of Man Shorthair
• Jaguarette
• Jaguarundi Curl
• Japanese Bobtail
• Japanese Bobtail Longhair
• Japanese Bobtail Shorthair
• Japanese domestic
• Javanese
• Jungala
• Jungle Cat
• Jungle Curl
• Jungle Lynx
• Junglebob
• Kanaani
• Karelian Bobtail
• Karelian Bobtail Longhair
• Khao Manee
• Khaomanee
• Kinkalow
• Korat
• Korean Bobtail
• Korn Ja
• Kurilian Bobtail
• Kurilian Bobtail Longhair
• Kurilian Bobtail Shorthair
• Lambkin
• LaPerm
• LaPerm Longhair
• LaPerm Shorthair
• Lykoi
• Maine Coon
• Maine Coon Polydactyl
• Manx
• Manx Longhair
• Manx Shorthair
• Me-kong Bobtail
• Meerkat
• Mekong Bobtail
• Minskin
• Minuet
• Minuet Longhair
• Mixed Breed
• Mohave Bob
• Mojave Spotted
• Mokave Jag Cat
• Mountain Bob
• Munchkin
• Munchkin Longhair
• Napoleon
• Nebelung
• Neva Masquerade
• Niebelung
• Non Recognized Hairless
• Non Recognized Longhair
• Non Recognized Shorthair
• Norwegian Forest Cat
• Ocicat
• Ojos Azules
• Oregon Rex (extinct)
• Oriental
• Oriental Bicolor
• Oriental Longhair
• Oriental Shorthair
• Original Longhair
• Owyhee Bob
• Pantherette
• Persian
• Peterbald
• Pharaoh
• Pixiebob
• Pixiebob Longhair
• Puppykat
• Raas
• Ragamuffin
• Ragdoll
• Ruffle
• Russian
• Russian Black
• Russian Blue
• Russian Tabby
• Russian White
• Rusty Spotted Cat
• Sacred Birman
• Safari
• Sam Sawet
• Sashkin Rex
• Savannah
• Scottish Fold
• Scottish Fold Longhair
• Scottish Longhair
• Scottish Shorthair
• Scottish Straight
• Scottish Straight Longhair
• Selkirk Rex
• Selkirk Rex Longhair
• Selkirk Rex Shorthair
• Selkirk Straight
• Serengeti
• Serrade Petit
• Serval
• Siamese
• Siamese Longhair
• Siberian
• Singapura
• Skookum
• Snowbob
• Snowshoe
• Sokoke
• Somali
• Sphynx
• Suffolk
• Suphalak
• Tennessee Bobtail
• Tennessee Rex
• Thai
• Thai Blue Point
• Thai Lilac
• Thai Lilac Point
• Tiffanie
• Tigrette
• Tonkinese
• Tonkinese Longhair
• Tonkinese Shorthair
• Toybob
• Toyger
• Traditional Siamese
• Transylvanian
• Tundra
• Turkish Angora
• Turkish Van
• Turkish Vankedisi
• Ukrainian Levkoy
• Unknown
• Ural Rex
• Ural Rex Longhair
• Vienna Woods
• Viverral
• York Chocolate

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🧬 Interpretation of genotypes CystIA

❓ Learn more about the interpretation of genotypes

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

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DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Cystinuria Type I-A (CystIA) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation SLC3A1 c.1342C>T.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Mizukami K, Raj K, Giger U. Feline cystinuria caused by a missense mutation in the SLC3A1 gene. J Vet Intern Med. 2015 Jan;29(1):120-5. doi: 10.1111/jvim.12501. Epub 2014 Nov 24.