Dog Cerebellar Degeneration-Myositis Complex (CDMC)

Cerebellar Degeneration-Myositis Complex (CDMC) is a genetic condition affecting dogs, leading to severe neurological and muscular issues. A DNA test for CDMC can help identify carriers and affected dogs, allowing for informed breeding decisions. Early detection through genetic testing is crucial, as it enables proactive management and care for affected pets. Owners should consult with veterinarians to understand the implications of a positive CDMC test result. By prioritizing genetic health, dog breeders can contribute to the overall wellness of future generations. Ensure your dog's health and well-being by considering a DNA test for CDMC today. Stay informed and take action to protect your furry friends from hereditary conditions.

Abbreviation : CDMC

Analysed mutation : SLC25A12 c.1337C>T

Inheritance : Autosomal Recessive

Acronym

CDMC

Observed frequency

Rare

Clinical severity

Severe

Clinical classification

Neuromuscular Diseases

Analysed mutation

SLC25A12 c.1337C>T
p.(P446L)

Mode of inheritance

Autosomal Recessive

Test summary:

Cerebellar Degeneration-Myositis Complex (CDMC) is a genetic condition affecting certain dog breeds, leading to neurological and muscular issues. A DNA test can identify carriers and affected individuals, helping breeders make informed decisions to reduce the prevalence of this complex disorder. Symptoms may include coordination problems and muscle weakness, which can significantly impact a dog's quality of life. Early detection through genetic testing allows for better management and care. Responsible breeding practices are essential in minimizing the risk of CDMC in future generations.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Understanding Cerebellar Degeneration-Myositis Complex (CDMC)

Cerebellar Degeneration-Myositis Complex (CDMC) is a serious neurological and muscular condition that affects dogs. This complex disease is characterized by two main components: cerebellar degeneration, which impacts the brain's ability to coordinate movement, and myositis, an inflammatory condition of the muscles. Together, these issues can lead to a range of debilitating symptoms that impact a dog's quality of life.

Symptoms and Clinical Manifestations

Dogs suffering from CDMC often exhibit a variety of symptoms that may vary in severity. Common clinical signs include ataxia, which is a lack of coordination and balance, leading to difficulty in walking and performing routine activities. Affected dogs may also display tremors, muscle weakness, and a noticeable decline in muscle mass due to myositis. In some cases, the condition may cause behavioral changes, including lethargy or reluctance to engage in physical activities.

Pathophysiology of CDMC

The pathophysiology of CDMC involves a combination of neurological and immunological factors. The cerebellum, responsible for coordination and balance, suffers from degeneration, while the immune system mistakenly targets muscle fibers, leading to inflammation. This dual impact results in the clinical signs observed in affected dogs. Research into the underlying genetic and environmental factors contributing to CDMC is ongoing, with a focus on understanding how these elements interact to trigger the disease.

Importance of DNA Testing

DNA testing plays a crucial role in identifying and diagnosing CDMC in dogs. By analyzing specific genetic markers associated with the condition, veterinary professionals can determine the likelihood of a dog carrying the genes responsible for CDMC. Early detection through DNA testing can provide pet owners with valuable information regarding their dog's health and guide them in making informed decisions about management and care.

Management and Treatment Options

Currently, there is no cure for CDMC; however, various management strategies can help improve a dog's quality of life. Supportive care, including physical therapy and nutritional support, can play a significant role in maintaining muscle strength and mobility. In some cases, medications to reduce inflammation and manage symptoms may be prescribed. Regular veterinary check-ups are essential for monitoring the condition and adjusting treatment plans as needed.

Conclusion

Cerebellar Degeneration-Myositis Complex (CDMC) is a complex and challenging condition that requires careful management and support. Understanding the nature of this disease, its symptoms, and potential treatment options is critical for pet owners. DNA testing serves as a valuable tool in the early detection and management of CDMC, enabling better health outcomes for affected dogs.

Breed recognized for the test : Cerebellar Degeneration-Myositis Complex (CDMC)

Nova Scotia Duck Tolling Retriever

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes CDMC

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/CDMC

Carrier - No Risk

❌ CDMC/CDMC

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/CDMC (Carrier)

CDMC/CDMC (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Cerebellar Degeneration-Myositis Complex (CDMC) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation SLC25A12 c.1337C>T.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Christen Matthias, Rupp Stefan, Van Soens Iris, Bhatti Sofie F M, Matiasek Kaspar, von Klopmann Thilo, Jagannathan Vidhya, Madden Indiana, Batcher Kevin, Bannasch Danika, Leeb Tosso. SLC25A12 Missense Variant in Nova Scotia Duck Tolling Retrievers Affected by Cerebellar Degeneration-Myositis Complex (CDMC). Genes (Basel). 2022 Jul 9;13(7):1223. doi: 10.3390/genes13071223.

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