Dog Canine Scott Syndrome (CSS)

Discover the essential DNA test for Canine Scott Syndrome in dogs, a rare inherited disorder affecting cardiac and neurological health. Early detection through genetic testing allows veterinarians and breeders to identify carriers and affected dogs, promoting healthier breeding decisions. The Canine Scott Syndrome DNA test provides accurate, reliable results, helping prevent the spread of this hereditary condition. Protect your dog's well-being by screening for genetic disorders with the latest canine DNA testing services. Knowledge of your dog's genetic health ensures better management and improves quality of life. Stay informed—choose a reputable DNA test to detect Canine Scott Syndrome today. Ensure your dog’s future health with comprehensive genetic testing.

Abbreviation : CSS

Analysed mutation : ANO6 c.1934+1G>A

Inheritance : Autosomal Recessive

Acronym

CSS

Observed frequency

Rare

Clinical severity

Moderate

Clinical classification

Haematological Diseases

Analysed mutation

ANO6 c.1934+1G>A

Mode of inheritance

Autosomal Recessive

Alternate name:

Platelet Factor X Receptor Deficiency

Test summary:

Canine Scott Syndrome is a rare inherited disorder affecting dogs, characterized by a deficiency in platelet function. This condition leads to increased bleeding and easy bruising, often presenting in young dogs. A DNA test can accurately diagnose the syndrome by identifying specific genetic mutations. Early detection allows veterinarians to manage symptoms effectively and prevent complications. Regular testing is recommended for breeds known to carry the mutation.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Choose the pack that best fits your breeding or health strategy of your animals.

Understanding Canine Scott Syndrome

Canine Scott Syndrome is a rare inherited bleeding disorder that affects dogs, characterized by a deficiency in platelet function. Unlike other bleeding disorders that result from a decrease in platelet count, Scott Syndrome involves a defect in the ability of platelets to expose phosphatidylserine on their surface, which is essential for proper blood clotting. This defect impairs the blood's ability to form stable clots, leading to an increased risk of bleeding episodes.

Genetic Basis of Canine Scott Syndrome

The condition is inherited in an autosomal recessive manner, meaning that a dog must inherit two copies of the mutated gene—one from each parent—to be affected. Carriers, with only one copy of the mutation, usually do not exhibit symptoms but can pass the gene to offspring. The genetic mutation responsible for Scott Syndrome affects the pathways involved in platelet activation and phospholipid scrambling, crucial processes in the coagulation cascade.

Symptoms and Clinical Presentation

Dogs affected by Scott Syndrome typically present with easy bruising, spontaneous bleeding, prolonged bleeding after injuries or surgeries, and in some cases, bleeding into joints or tissues. The severity of symptoms can vary depending on the extent of platelet dysfunction. Often, affected dogs may not show signs until an injury occurs or during surgical procedures, when bleeding complications become evident.

Importance of DNA Testing for Canine Scott Syndrome

The DNA test for Scott Syndrome plays a vital role in identifying carriers and affected dogs, facilitating informed breeding decisions to prevent the spread of the disorder. Early diagnosis through genetic testing allows veterinarians and breeders to implement appropriate management strategies, such as avoiding trauma, planning for potential bleeding complications during surgeries, and reducing the incidence of affected puppies in the population. It also helps in understanding the prevalence of the condition within specific breeds or bloodlines.

Implications of the Test Results

Testing can confirm whether a dog is affected, a carrier, or clear of the mutation. An affected dog requires careful medical management to prevent bleeding episodes, especially during surgeries or injuries. Carriers are generally asymptomatic but should be considered in breeding programs to prevent passing the mutation to offspring. Dogs that test clear are not at risk of developing or passing on the disorder, contributing to healthier bloodline management.

Conclusion

DNA testing for Canine Scott Syndrome is an essential tool for responsible breeding and health management. By accurately identifying affected dogs and carriers, owners and breeders can make informed decisions that promote canine health and reduce the prevalence of this inherited bleeding disorder in the dog population.

Breed recognized for the test : Canine Scott Syndrome (CSS)

American White Shepherd Dog
Beagle
Chinese Crested
German Shepherd Dog
Shiloh Shepherd
Swiss White Shepherd Dog

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes CSS

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/CSS

Carrier - No Risk

❌ CSS/CSS

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/CSS (Carrier)

CSS/CSS (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Canine Scott Syndrome in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation ANO6 c.1934+1G>A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Brooks M B, Catalfamo J L, MacNguyen R, Tim D, Fancher S, McCardle J A. A TMEM16F point mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling. J Thromb Haemost. 2015 Dec;13(12):2240-52. doi: 10.1111/jth.13157. Epub 2015 Nov 20.

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