Čo znamená „Vymazať“?
Zviera nie je nositeľom mutácie. Nerozvinie chorobu a neprenesie to ďalej.
Pes Nedostatok adhézie psích leukocytov (CLAD)
Discover the importance of DNA testing for Canine Leukocyte Adhesion Deficiency (CLAD) in dogs. CLAD is a serious genetic disorder affecting the immune system, making dogs more susceptible to infections. Early detection through a simple DNA test can help pet owners make informed breeding decisions and ensure healthier puppies. Understanding CLAD allows for better management of affected dogs, improving their quality of life. This test is crucial for breeds prone to this condition, such as Irish Setters. Protect your furry friend with proactive measures by opting for a CLAD DNA test today. Invest in your dog’s health and well-being—knowledge is power!
skratka: CLAD
Analyzovaná mutácia: ITGB2 c.107G>C
Dedičstvo: Autozomálne recesívne
Skratka
CLAD
Pozorovaná frekvencia
Klinická závažnosť
Klinická klasifikácia
Imunologické choroby
Analyzovaná mutácia
ITGB2 c.107G>C
p.(C36S)
p.(C36S)
Spôsob dedenia
Autozomálne recesívne (Dokončené)
Zhrnutie testu:
Canine Leukocyte Adhesion Deficiency (CLAD) is a genetic disorder that affects the immune system of dogs, particularly prevalent in certain breeds like the Irish Setter. This condition impairs the ability of white blood cells to adhere to blood vessel walls, leading to increased susceptibility to infections. A DNA test can identify carriers and affected dogs, helping breeders make informed decisions to reduce the incidence of CLAD in future generations. Early detection through testing is crucial for managing the health of affected dogs. Responsible breeding practices can help eliminate this debilitating condition from the gene pool.
Dostupné z balenia: Basic
Tento test DNA je súčasťou balenia od nášho balenia Basic — a je tiež súčasťou balenia Basic, Standard, Advanced, Complete.
Zobraziť balíčky testov DNA →Vyberte si balenie, ktoré najlepšie vyhovuje vašej chovateľskej alebo zdravotnej stratégii vašich zvierat.
Understanding Canine Leukocyte Adhesion Deficiency (CLAD)
Canine Leukocyte Adhesion Deficiency (CLAD) is a genetic disorder primarily affecting the immune system of dogs. It is caused by a mutation in a specific gene that is responsible for the development and function of leukocytes, or white blood cells. This condition leads to an inability of leukocytes to adhere to blood vessel walls, which is crucial for their migration to sites of infection or inflammation.
Clinical Signs of CLAD
Dogs affected by CLAD typically exhibit a range of clinical signs due to their compromised immune response. Common symptoms include recurrent infections, poor wound healing, and chronic inflammation. Affected dogs may also show signs of systemic illness, such as fever, lethargy, and weight loss. The severity of these symptoms can vary widely among individuals, depending on the extent of their immune dysfunction.
Diagnosis of CLAD
The diagnosis of CLAD is primarily achieved through genetic testing. A DNA test specifically designed to identify the mutation associated with CLAD can confirm the diagnosis. This test is crucial for breeders and dog owners to understand the genetic status of their dogs and to make informed breeding decisions. Early detection can also help in managing the health of affected dogs more effectively.
Manažment a liečba
Currently, there is no cure for CLAD; however, management strategies can be employed to improve the quality of life for affected dogs. Treatment often involves prompt and aggressive management of infections with antibiotics and supportive care. Additionally, owners may need to take extra precautions to minimize exposure to pathogens, such as avoiding dog parks or other areas where dogs congregate.
Importance of Genetic Testing
Genetic testing for CLAD is vital for responsible breeding practices. By identifying carriers and affected individuals, breeders can make informed decisions to avoid producing affected puppies. This not only helps in reducing the prevalence of the condition in the population but also promotes overall canine health and welfare.
Záver
Canine Leukocyte Adhesion Deficiency is a serious genetic condition that poses significant health challenges for affected dogs. Understanding this disorder, recognizing its symptoms, and utilizing genetic testing are essential steps in managing the condition and ensuring the health of future generations of dogs. By prioritizing genetic health, dog owners and breeders can contribute to a healthier canine population.
Plemeno uznané na skúšku: Nedostatok adhézie psích leukocytov (CLAD)
- Irish Red and White Setter
- Irish Setter
- Irishdoodle
🧬 Interpretation of genotypes CLAD
Genotyp
Stav
🟡 N/N
Neprepravca – žiadne riziko
🟡 N/CLAD
Prepravca – žiadne riziko
❌ CLAD/CLAD
Ovplyvnené – v ohrození
FAQ: pochopenie výkladu
Myslí to „prepravca“ vážne?
Nie. Zviera je vo všeobecnosti zdravé, ale môže naň preniesť mutáciu potomstvo.
Čo ak je zviera „postihnuté“?
Nesie dve mutované kópie. Klinické príznaky sa očakávajú v závislosti od choroby. Nemalo by sa chovať.
Prečo sú rozdiely medzi mužmi a ženami?
Niektoré choroby sú viazané na pohlavie, takže ich prejav sa líši v závislosti od pohlavie zvieraťa.
Predpovedať potomka
N/N (neprepravca)
N/CLAD (Nosič)
CLAD/CLAD (Ovplyvnené)
Časté otázky o teste DNA
Čo zistí tento test DNA?
This DNA test detects the mutation associated with Canine Leukocyte Adhesion Deficiency (CLAD) in order to identify clear, carrier, or at-risk animals.
Prečo testovať chovné zviera?
Testovanie DNA pomáha chovateľom plánovať bezpečnejšie párenie a znižovať riziko prenosu mutácie na potomstvo.
Aký je režim dedičnosti tohto testu?
Režim dedičnosti uvedený pre tento test je autozomálne recesívny.
Ktorá mutácia sa analyzuje v tomto teste?
This test analyses the mutation ITGB2 c.107G>C.
Je nutne postihnuté zviera-nosič?
Nie nevyhnutne. Interpretácia závisí od vzoru dedičnosti a výsledného genotypu.
Referencie
Kijas J M, Bauer T R Jr, Gäfvert S, Marklund S, TrowaldWigh G, Johannisson A, Hedhammar A, Binns M, Juneja R K, Hickstein D D, Andersson L. A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics. 1999 Oct 1;61(1):101-7. doi: 10.1006/geno.1999.5948.