O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cavalo Síndrome de fragilidade de potro de sangue quente (WFFS)
The Warmblood Foal Fragility Syndrome (WFFS) DNA test is essential for horse breeders aiming to prevent this genetic disorder. WFFS is a hereditary condition affecting connective tissue, leading to fragile skin and early foal mortality. By using the WFFS DNA test, breeders can identify carriers and make informed breeding decisions to reduce the risk of affected foals. This test is quick, accurate, and widely recommended for Warmblood horses. Early detection through DNA testing helps maintain healthy bloodlines and improves overall herd quality. Ensure your Warmblood breeding program is safe by incorporating the WFFS DNA test today. Protect your foals and promote responsible breeding with this vital genetic screening.
Abreviatura: WFFS
Mutação analisada: PLOD1 c.2032G/A
Herança: Autossômico Recessivo
Acrônimo
WFFS
Frequência observada
Gravidade clínica
Classificação clínica
Transtornos do Desenvolvimento
Mutação analisada
PLOD1 c.2032G/A
p.(G678R)
p.(G678R)
Modo de herança
Autossômico Recessivo (Completo)
Resumo do teste:
Warmblood Foal Fragility Syndrome (WFFS) is a genetic disorder affecting horses, particularly warmblood breeds. It is caused by a mutation in the PLOD1 gene, leading to fragile skin and connective tissues in foals. A DNA test can identify carriers of the WFFS mutation, helping breeders avoid mating two carriers. Preventing carrier-to-carrier breeding reduces the risk of producing affected foals. This test is an important tool for responsible breeding and maintaining healthy horse populations.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Introduction to Warmblood Foal Fragility Syndrome (WFFS)
Warmblood Foal Fragility Syndrome (WFFS) is a genetic disorder that affects foals, primarily within certain equine breeds. This condition results from a mutation in the gene responsible for collagen production, which is vital for the structural integrity of connective tissues. As a consequence, affected foals exhibit extreme fragility, making them susceptible to severe injuries and complications, particularly during the birthing process or shortly after birth.
Clinical Signs of WFFS
Foals diagnosed with WFFS typically display a range of clinical symptoms that can vary in severity. Common indicators include skin that is incredibly thin and fragile, which can lead to easy tearing and bruising. Additionally, these foals may experience joint laxity, making them prone to dislocations and other orthopedic issues. Other signs can include respiratory difficulties and a failure to thrive, which can significantly impact their overall development and survival rates.
Management and Care of Affected Foals
Managing a foal with WFFS requires a specialized approach to ensure their well-being. Due to their fragile condition, it is crucial to provide a calm and safe environment to minimize the risk of injury. Veterinary care is essential, including regular monitoring for any signs of complications. Supportive care, such as appropriate nutrition and gentle handling, can help improve the quality of life for these foals. In some cases, surgical interventions may be necessary to address specific injuries or complications that arise.
Genetic Counseling and Prevention
For breeders, understanding WFFS is vital for making informed breeding decisions. Genetic counseling can provide valuable insights into the risks associated with breeding horses that may carry the WFFS gene. Implementing genetic testing as part of a breeding program can help prevent the birth of affected foals, thereby reducing the incidence of this condition in future generations. Awareness and education about WFFS can also empower breeders to make responsible choices that prioritize the health and welfare of their horses.
Conclusão
Warmblood Foal Fragility Syndrome is a serious genetic condition that poses significant challenges for affected foals and their caretakers. Awareness of the symptoms, management strategies, and prevention methods is crucial in mitigating the impact of this syndrome. Through responsible breeding practices and genetic testing, the equine community can work towards reducing the prevalence of WFFS, ensuring healthier outcomes for future foals.
Raça reconhecida para o teste: Síndrome de fragilidade de potro de sangue quente (WFFS)
- Thoroughbred
- Warmblood
🧬 Interpretation of genotypes WFFS
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/WFFS
Transportadora - Sem Risco
❌ WFFS/WFFS
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/WFFS (Operadora)
WFFS/WFFS (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Warmblood Foal Fragility Syndrom (WFFS) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation PLOD1 c.2032G/A.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Monthoux Chloé, de Brot Simone, Jackson Michelle, Bleul Ulrich, Walter Jasmin. Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC Vet Res. 2015 Jan 31;11:12. doi: 10.1186/s12917-015-0318-8.