O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Atrofia progressiva da retina 2 no Golden Retriever (GR-PRA2)
Progressive Retinal Atrophy 2 (GR-PRA2) is a hereditary eye disease affecting Golden Retrievers, leading to vision loss and eventual blindness. Early detection through a DNA test is crucial for responsible breeding and pet ownership. This genetic test identifies carriers of the GR-PRA2 mutation, allowing owners to make informed decisions about their dog's health. By screening breeding stock, we can reduce the prevalence of this condition in future generations. Regular eye check-ups and genetic testing can ensure your Golden Retriever enjoys a healthy, vibrant life. Protect your furry friend from GR-PRA2 by opting for a reliable DNA test today. Stay proactive and safeguard your dog's vision!
Abreviatura: GR-PRA2
Mutação analisada: TTC8 c.669delA
Herança: Autossômico Recessivo
Acrônimo
GR-PRA2
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Oftalmológicas
Mutação analisada
TTC8 c.669delA
p.(K223Rfs*15)
p.(K223Rfs*15)
Modo de herança
Autossômico Recessivo
Resumo do teste:
Progressive Retinal Atrophy 2 (GR-PRA2) is a hereditary eye disorder affecting Golden Retrievers, leading to gradual vision loss and potential blindness. This condition is caused by a specific genetic mutation, which can be identified through a simple DNA test. Early detection is crucial for managing the health of affected dogs and making informed breeding decisions. Responsible breeders often screen for GR-PRA2 to reduce the incidence of this condition in future generations. Owners are encouraged to consider genetic testing to ensure the well-being of their pets.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Progressive Retinal Atrophy 2 (GR-PRA2)
Progressive Retinal Atrophy 2 (GR-PRA2) is a hereditary eye condition that primarily affects Golden Retrievers. This progressive disease leads to the gradual degeneration of the retina, which is the light-sensitive layer at the back of the eye. The condition typically results in vision loss, which may begin with night blindness and can eventually lead to complete blindness.
Genetic Basis of GR-PRA2
GR-PRA2 is caused by mutations in a specific gene that plays a crucial role in the health and function of photoreceptor cells in the retina. These cells are responsible for detecting light and enabling vision. As the disease progresses, the photoreceptor cells deteriorate, affecting the dog's ability to perceive visual stimuli effectively.
Symptoms of GR-PRA2
Dogs affected by GR-PRA2 may exhibit a range of symptoms related to vision impairment. Initially, owners may notice that their pet has difficulty seeing in low-light conditions, such as during the evening or in dimly lit areas. As the condition advances, dogs may also struggle with daytime vision, bumping into objects or displaying hesitance when navigating their surroundings. Other signs may include increased anxiety in unfamiliar environments, reluctance to engage in activities that require good vision, and changes in behavior due to frustration or confusion.
Importância da detecção precoce
Early detection of GR-PRA2 is crucial for managing the condition effectively. Regular veterinary check-ups and eye examinations can help identify the onset of retinal degeneration. While there is currently no cure for GR-PRA2, early diagnosis allows pet owners to make necessary adjustments in their dog's environment and lifestyle to enhance their quality of life as their vision changes.
Management and Support for Affected Dogs
While there is no definitive treatment for GR-PRA2, several strategies can help manage the condition and support affected dogs. Creating a safe, predictable environment is essential, as this can help dogs navigate their surroundings more easily. Owners are encouraged to maintain consistent routines and minimize changes in furniture layout to reduce confusion. Training and socialization can also assist dogs in adapting to their vision loss, fostering confidence and independence.
Conclusão
Progressive Retinal Atrophy 2 (GR-PRA2) is a significant concern for Golden Retriever owners, impacting the dog's vision and overall quality of life. Awareness of the condition, along with proactive measures for early detection and supportive management, can help enhance the well-being of affected dogs. Through understanding and care, owners can ensure that their pets continue to live fulfilling lives despite the challenges posed by this hereditary eye condition.
Raça reconhecida para o teste: Atrofia progressiva da retina 2 no Golden Retriever (GR-PRA2)
- Golden Retriever
- Goldendoodle
- Lab/Golden Cross
- Labradoodle
- Labrador Retriever
- UK Breed Council Labrador Retriever
🧬 Interpretation of genotypes GR-PRA2
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/GR-PRA2
Transportadora - Sem Risco
❌ GR-PRA2/GR-PRA2
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/GR-PRA2 (Operadora)
GR-PRA2/GR-PRA2 (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Progressive Retinal Atrophy 2 In Golden Retriever (GR-PRA2) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation TTC8 c.669delA.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Downs Louise M, WallinHåkansson Berit, Bergström Tomas, Mellersh Cathryn S. A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever. Canine Genet Epidemiol. 2014 Apr 16;1:4. doi: 10.1186/2052-6687-1-4. eCollection 2014.