O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Cegueira noturna estacionária congênita em Briard (CSNB-Br)
The DNA test for Congenital Stationary Night Blindness (CSNB) in Briard dogs is essential for responsible breeding. CSNB is a hereditary eye disorder causing impaired night vision from birth, affecting the dog’s quality of life. Early genetic testing helps identify carriers and affected dogs, preventing the spread of this condition within the breed. By using the CSNB DNA test, breeders can make informed decisions to maintain healthy Briard lineages. This test is simple, accurate, and vital for preserving your dog’s vision and overall health. Ensure your Briard’s future with reliable CSNB genetic screening today. Protect your dog’s eyesight with expert DNA testing for CSNB in Briards.
Abreviatura: CSNB-Br
Mutação analisada: RPE65 c.460_463del
Herança: Autossômico Recessivo
Acrônimo
CSNB-Br
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Oftalmológicas
Mutação analisada
RPE65 c.460_463del
p.(K154Lfs*53)
p.(K154Lfs*53)
Modo de herança
Autossômico Recessivo (Completo)
Resumo do teste:
The DNA test for Congenital Stationary Night Blindness (CSNB) in Briard dogs helps identify carriers and affected individuals. CSNB is a hereditary eye disorder causing impaired night vision from birth. Early genetic testing allows breeders to make informed decisions to reduce the incidence of this condition. The test detects specific mutations linked to CSNB in the Briard breed. Responsible breeding based on DNA results promotes healthier puppies with better vision.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Congenital Stationary Night Blindness (CSNB) in Briards
Congenital Stationary Night Blindness (CSNB) is a hereditary condition that affects the vision of dogs, particularly in low-light environments. This condition is characterized by a defect in the retinal cells, specifically the photoreceptors that are responsible for night vision. As a result, affected dogs experience significant difficulty seeing in dim light, which can lead to challenges in their daily activities and overall quality of life.
Clinical Signs of CSNB
Dogs suffering from CSNB typically exhibit specific clinical signs that indicate their vision impairment. These signs may include reluctance to walk in dark areas, bumping into objects, and an unusual hesitance when navigating unfamiliar environments. Interestingly, affected dogs often have normal vision in bright light, which can sometimes lead to misconceptions about their overall sight capabilities.
Genetics of CSNB
The genetic basis of CSNB is linked to mutations in specific genes responsible for retinal function. In Briards, the condition is inherited in an autosomal recessive manner, meaning that both copies of the gene must carry the mutation for the condition to manifest. This genetic understanding is crucial for breeders aiming to reduce the incidence of CSNB within the breed.
Diagnosis of CSNB
While DNA testing is a definitive method for diagnosing CSNB, veterinarians may also use additional techniques to assess a dog's vision. These can include electroretinography (ERG), which measures the electrical responses of the retina to light stimulation, and comprehensive eye examinations by veterinary ophthalmologists. Early diagnosis can help in managing the condition effectively, allowing owners to make informed decisions regarding their dog's care.
Management and Care for Affected Dogs
Currently, there is no cure for CSNB; however, management strategies can help improve the quality of life for affected dogs. Owners can create a safe and accommodating environment by minimizing exposure to low-light situations and ensuring that their pets have a clear understanding of their surroundings. Additionally, providing mental stimulation and training can help affected dogs adapt to their vision limitations.
Conclusão
Understanding Congenital Stationary Night Blindness in Briards is essential for breeders and dog owners alike. By being aware of the genetic implications and clinical signs associated with this condition, responsible breeding practices can be implemented, and proactive measures can be taken to support the well-being of affected dogs. Ongoing research into the genetic aspects of CSNB will contribute to better management strategies and potential future therapies.
Raça reconhecida para o teste: Cegueira noturna estacionária congênita em Briard (CSNB-Br)
- Briard
🧬 Interpretation of genotypes CSNB-Br
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/CSNB-Br
Transportadora - Sem Risco
❌ CSNB-Br/CSNB-Br
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/CSNB-Br (Operadora)
CSNB-Br/CSNB-Br (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Congenital Stationary Night Blindness In Briard (CSNB-Br) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation RPE65 c.460_463del.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Aguirre G D, Baldwin V, PearceKelling S, Narfström K, Ray K, Acland G M. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis. 1998 Oct 30;4:23.