O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Síndrome Miastênica Congênita em Golden Retriever (CMS-GR)
Unlock the secrets to your Golden Retriever's health with a DNA test for Congenital Myasthenic Syndrome (CMS). This genetic condition can significantly impact your dog's quality of life, making early detection essential. By identifying mutations associated with CMS, you can take proactive steps to manage your pet's well-being. Our comprehensive DNA test offers peace of mind, ensuring you stay informed about your dog's genetic predispositions. With accurate results, you can work closely with your veterinarian to tailor a care plan suited to your Golden Retriever's needs. Don't wait—invest in your dog's health today and ensure a happier, healthier future. Discover more about our DNA testing services for CMS in Golden Retrievers now!
Abreviatura: CMS-GR
Mutação analisada: LOC608697 c.880G>A
Herança: Autossômico Recessivo
Acrônimo
CMS-GR
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Neuromusculares
Mutação analisada
LOC608697 c.880G>A
p.(G294R)
p.(G294R)
Modo de herança
Autossômico Recessivo
Resumo do teste:
Congenital Myasthenic Syndrome (CMS) is a genetic disorder affecting Golden Retrievers, characterized by muscle weakness and fatigue. A DNA test can help identify carriers of the mutation responsible for this condition, enabling early diagnosis and management. Affected dogs may struggle with basic activities, impacting their quality of life. Responsible breeding practices, informed by genetic testing, can reduce the incidence of CMS in future generations. Pet owners are encouraged to consult veterinarians for guidance on testing and care options.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Congenital Myasthenic Syndrome (CMS)
Congenital Myasthenic Syndrome (CMS) is a hereditary neuromuscular disorder that affects the transmission of signals between nerves and muscles. In Golden Retrievers, this condition can lead to significant muscle weakness and fatigue, impacting the dog’s ability to perform everyday activities. CMS is caused by mutations in genes responsible for the production of proteins that form the neuromuscular junction, which is crucial for muscle contraction.
Symptoms of CMS in Golden Retrievers
Symptoms of CMS can vary in severity but commonly include muscle weakness, especially after periods of activity. Affected dogs may exhibit difficulty in climbing stairs, running, or even standing for extended periods. Other signs may include a lack of stamina and an increased tendency to collapse after exertion. In some cases, symptoms may become more pronounced as the dog ages, leading to challenges in mobility and overall quality of life.
Diagnosis of CMS
Diagnosing Congenital Myasthenic Syndrome typically involves a combination of clinical observation and genetic testing. Veterinarians will evaluate the dog's muscle function and may conduct electromyography (EMG) to assess the electrical activity of muscles. Genetic testing plays a pivotal role in confirming the diagnosis, allowing for the identification of specific mutations associated with CMS.
Treatment Options for CMS
While there is currently no cure for CMS, various treatment options can help manage the symptoms and improve the quality of life for affected Golden Retrievers. Treatment may include medications that enhance neuromuscular transmission, such as acetylcholinesterase inhibitors. Physiotherapy and supportive care can also be beneficial, helping to maintain muscle strength and mobility. Regular veterinary check-ups are essential to monitor the dog's condition and adjust treatment as needed.
Prognosis and Management
The prognosis for Golden Retrievers diagnosed with Congenital Myasthenic Syndrome can vary widely based on the severity of the condition and the specific genetic mutation involved. With appropriate management, many dogs can lead fulfilling lives, although they may require ongoing care and monitoring. It's crucial for owners to work closely with their veterinarians to develop a tailored care plan that addresses the unique needs of their dog.
Importance of Genetic Testing
Genetic testing for Congenital Myasthenic Syndrome is an important tool for breeders and dog owners alike. By identifying carriers of the disease, breeders can make informed decisions to reduce the incidence of CMS in future litters. For pet owners, understanding the genetic risk can enable proactive management and planning for potential health challenges, ensuring that affected dogs receive the best possible care.
Raça reconhecida para o teste: Síndrome Miastênica Congênita em Golden Retriever (CMS-GR)
- Golden Retriever
- Goldendoodle
- Lab/Golden Cross
🧬 Interpretation of genotypes CMS-GR
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/CMS-GR
Transportadora - Sem Risco
❌ CMS-GR/CMS-GR
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/CMS-GR (Operadora)
CMS-GR/CMS-GR (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Congenital Myasthenic Syndrome In Golden Retriever (CMS) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation LOC608697 c.880G>A.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Tsai Kate L, Vernau Karen M, Winger Kathryn, Zwueste Danielle M, Sturges Beverly K, Knipe Marguerite, Williams D Colette, Anderson Kendall J, Evans Jacquelyn M, Guo Ling T, Clark Leigh Anne, Shelton G Diane. Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation. J Vet Intern Med. 2020 Jan;34(1):258-265. doi: 10.1111/jvim.15667. Epub 2019 Nov 26.