O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Hipertermia Maligna Canina (HM)
Discover the importance of DNA testing for Canine Malignant Hyperthermia (MH) in dogs. This genetic disorder can lead to severe reactions during anesthesia, placing your furry friend at risk. By identifying the MH gene mutation through a simple DNA test, pet owners can make informed decisions about their dog's health and safety. Early detection allows for proactive management, ensuring a safer experience during veterinary procedures. Investing in a DNA test for Canine Malignant Hyperthermia can ultimately save lives and enhance your dog's well-being. Consult your veterinarian today to learn more about this vital genetic screening. Protect your pup with knowledge and peace of mind!
Abreviatura: MH
Mutação analisada: RYR1 c.1643T>C
Herança: Autossômico Dominante
Acrônimo
MH
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Metabólicas
Mutação analisada
RYR1 c.1643T>C
p.(V548A)
p.(V548A)
Modo de herança
Autossômico Dominante
Resumo do teste:
Canine Malignant Hyperthermia (MH) is a rare genetic disorder triggered by certain anesthetic agents in dogs. It leads to a severe and uncontrolled increase in body temperature, muscle rigidity, and metabolic disturbances. The condition is often linked to mutations in the ryanodine receptor gene. Prompt recognition and immediate treatment are crucial to prevent serious complications or death. Preventive measures include genetic testing and avoiding specific anesthetics in at-risk breeds.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Introduction to Canine Malignant Hyperthermia (MH)
Canine Malignant Hyperthermia (MH) is a rare but serious genetic disorder that affects certain dog breeds. It is characterized by an abnormal and severe response to specific stressors, such as anesthesia or extreme heat, leading to a rapid increase in body temperature and metabolic crisis. If not recognized and treated promptly, MH can be fatal for the affected dog.
Understanding the Condition
Malignant Hyperthermia in dogs is caused by a hereditary defect in the regulation of calcium within muscle cells. This defect leads to uncontrolled muscle contractions and a significant increase in metabolic activity, resulting in a rapid rise in core body temperature. Symptoms often include muscle rigidity, rapid breathing, increased heart rate, and a sudden onset of hyperthermia. The condition is often triggered by certain anesthetic agents or stress, making perioperative management critical.
Genetic Basis of Canine MH
The disorder is inherited in a manner similar to that observed in humans, with specific genetic mutations affecting calcium regulation pathways. Dogs carrying these mutations are predisposed to developing MH when exposed to triggering factors. Identifying affected dogs through DNA testing allows breeders and veterinarians to make informed decisions to prevent the spread of the disorder and to implement appropriate management strategies for affected animals.
O papel dos testes de DNA
DNA testing for canine MH involves analyzing specific genetic markers associated with the disorder. This test provides valuable information about an individual dog's genetic status, helping to identify carriers or affected animals. Early detection through DNA testing can assist in making preventative choices, such as avoiding certain medications or stressful situations that could trigger a crisis, thereby safeguarding the health and well-being of the dog.
Importance of Diagnosis and Management
Accurate diagnosis of MH through DNA testing is essential for effective management. Dogs identified as at risk can be provided with tailored anesthetic protocols, monitored closely during procedures, and kept in a stress-free environment. Additionally, knowing a dog’s genetic status helps inform breeding decisions to reduce the prevalence of the disorder within a breed population.
Raça reconhecida para o teste: Hipertermia Maligna Canina (HM)
- Bearded Collie
- Border Collie
- Doberman Pinscher
- Farm Collie
- German Shepherd Dog
- Labrador Retriever
- Old Farm Collie
- Rough Collie
- Scottish Collie
- Scottish Rough Collie
- Scottish Smooth Collie
- Smooth Collie
🧬 Interpretation of genotypes MH
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/MH
Transportadora - em risco
❌ MH/MH
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/MH (Operadora)
MH/MH (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Canine Malignant Hyperthermia (MH) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Dominante.
Qual mutação é analisada neste teste?
This test analyses the mutation RYR1 c.1643T>C.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Roberts M C, Mickelson J R, Patterson E E, Nelson T E, Armstrong P J, Brunson D B, Hogan K. Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel (RYR1). Anesthesiology. 2001 Sep;95(3):716-25. doi: 10.1097/00000542-200109000-00026.