O que significa “Limpar”?
O animal não carrega a mutação. Não desenvolverá a doença e não vai passar adiante.
Cachorro Síndrome de Mutilação Acral (SMA)
Acral Mutilation Syndrome (AMS) in dogs is a rare genetic disorder that affects certain breeds, leading to self-mutilation and severe pain. DNA testing for AMS is crucial for early diagnosis and prevention, helping pet owners understand their dog's genetic predisposition. By identifying carriers of the AMS gene, breeders can make informed decisions to reduce the incidence of this debilitating condition. Symptoms of AMS include excessive licking, biting, and injury to the paws and limbs. With the right genetic testing, owners can ensure better health outcomes for their pets. Don’t wait—consider a DNA test today to safeguard your dog's wellbeing. Discover peace of mind knowing you’re taking proactive steps for your furry friend!
Abreviatura: AMS
Mutação analisada: GDNF g.70875561C>T
Herança: Autossômico Recessivo
Acrônimo
AMS
Frequência observada
Gravidade clínica
Classificação clínica
Doenças Neurológicas
Mutação analisada
GDNF g.70875561C>T
Modo de herança
Autossômico Recessivo
Resumo do teste:
Acral Mutilation Syndrome (AMS) is a rare genetic disorder observed in certain dog breeds, characterized by self-mutilating behaviors and severe pain in the paws. A DNA test for AMS can identify carriers of the gene responsible for this condition, allowing breeders to make informed decisions and reduce the risk of passing it on to future generations. Early diagnosis through genetic testing can lead to better management and treatment options for affected dogs. This test is particularly crucial for breeds known to be predisposed to AMS, ensuring the health and well-being of these animals. Responsible breeding practices can help prevent the emergence of this distressing syndrome in canine populations.
Disponível no pacote: Basic
Este teste de DNA está incluído a partir do nosso pacote Basic - e também faz parte dos packs Basic, Standard, Advanced, Complete.
Ver pacotes de teste de DNA →Escolha o pack que melhor se adapta à sua estratégia de criação ou saúde dos seus animais.
Understanding Acral Mutilation Syndrome (AMS) in Dogs
Acral Mutilation Syndrome (AMS) is a genetic condition that primarily affects certain dog breeds, leading to severe and often painful self-mutilation of the paws and limbs. This disorder is characterized by the loss of skin and tissue, which can result in significant discomfort and complications for affected dogs. AMS is a hereditary condition, and understanding its genetic basis is crucial for breeders and veterinarians alike in managing and preventing its occurrence.
The Role of DNA Testing in AMS
DNA testing for Acral Mutilation Syndrome offers a reliable method for identifying carriers of the gene responsible for this condition. By analyzing specific genetic markers associated with AMS, veterinarians and breeders can make informed decisions about breeding practices. This proactive approach helps reduce the incidence of the syndrome in future generations and promotes the overall health of the population.
Sinais e Sintomas Clínicos
Dogs with Acral Mutilation Syndrome typically exhibit a range of clinical signs, including self-inflicted wounds on the paws and limbs. These wounds can lead to secondary infections, discomfort, and even behavioral changes due to pain and distress. Owners may notice that affected dogs exhibit compulsive licking or chewing at their limbs, which exacerbates the condition. In severe cases, the mutilation can result in significant tissue damage and require surgical intervention.
Opções de manejo e tratamento
While there is no cure for Acral Mutilation Syndrome, effective management strategies can help alleviate the symptoms and improve the quality of life for affected dogs. Treatment may include pain management, wound care, and behavioral modification therapies to reduce the urge to self-mutilate. In some cases, veterinarians may recommend the use of protective devices, such as Elizabethan collars or paw wraps, to prevent further injury while the dog heals.
Importance of Genetic Counseling
Genetic counseling plays a vital role in addressing Acral Mutilation Syndrome. Breeders should seek guidance from geneticists to understand the implications of producing offspring from affected or carrier animals. By utilizing DNA testing and adhering to responsible breeding practices, the risks associated with AMS can be significantly mitigated, ensuring healthier dogs and promoting ethical breeding standards.
Conclusão
Acral Mutilation Syndrome is a serious genetic condition that poses significant challenges for affected dogs and their owners. DNA testing serves as a crucial tool in identifying carriers and managing the condition effectively. Through a combination of early detection, responsible breeding, and comprehensive care, the impact of AMS can be minimized, leading to healthier lives for dogs and greater peace of mind for their caregivers.
Raça reconhecida para o teste: Síndrome de Mutilação Acral (SMA)
- American Cocker Spaniel
- Black Cocker Spaniel
- Cockapoo
- English Cocker Spaniel
- English Springer Spaniel
- French Spaniel
- German Shorthaired Pointer
- Old English Sheepdog
- Pointer
- Sheepadoodle
- Welsh Cocker Spaniel
- Welsh Springer Spaniel
- Working Cocker Spaniel
🧬 Interpretation of genotypes AMS
Genótipo
Status
🟡 N/N
Não portador - sem risco
🟡 N/AMS
Transportadora - Sem Risco
❌ AMS/AMS
Afetados - Em risco
FAQ: entendendo a interpretação
Um “transportador” é sério?
Não. O animal é geralmente saudável, mas pode transmitir a mutação ao seu descendência.
E se um animal for “afetado”?
Ele carrega duas cópias mutadas. Os sinais clínicos são esperados dependendo a doença. Não deveria ser criado.
Por que existem diferenças entre homem/mulher?
Algumas doenças estão ligadas ao sexo, pelo que a sua expressão varia dependendo do sexo do animal.
Prever descendência
N/N (nao-portador)
N/AMS (Operadora)
AMS/AMS (Afetado)
Perguntas frequentes sobre testes de DNA
O que este teste de DNA detecta?
This DNA test detects the mutation associated with Acral Mutilation Syndrome (AMS) in order to identify clear, carrier, or at-risk animals.
Por que testar um animal reprodutor?
Os testes de DNA ajudam os criadores a planejar acasalamentos mais seguros e a reduzir o risco de transmissão da mutação aos descendentes.
Qual é o modo de herança deste teste?
O modo de herança relatado para este teste é Autossômico Recessivo.
Qual mutação é analisada neste teste?
This test analyses the mutation GDNF g.70875561C>T.
Um animal portador é necessariamente afetado?
Não necessariamente. A interpretação depende do padrão de herança e do genótipo resultante.
Referências
Plassais Jocelyn, Lagoutte Laetitia, Correard Solenne, Paradis Manon, Guaguère Eric, Hédan Benoit, Pommier Alix, Botherel Nadine, Cadiergues MarieChristine, Pilorge Philippe, Silversides David, Bizot Maud, Samuels Mark, Arnan Carme, Johnson Rory, Hitte Christophe, Salbert Gilles, Méreau Agnès, Quignon Pascale, Derrien Thomas, André Catherine. A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies. PLoS Genet. 2016 Dec 29;12(12):e1006482. doi: 10.1371/journal.pgen.1006482. eCollection 2016 Dec.