Cat Hypertrophic Cardiomyopathy In Domestic Shorthair (HCM-DSH)

Discover the importance of the DNA test for Hypertrophic Cardiomyopathy (HCM) in Domestic Shorthair cats, a common genetic heart condition. Early detection through this specialized DNA test helps identify cats at risk, enabling timely veterinary care and management. HCM can lead to serious health issues, including heart failure, making genetic screening essential for responsible breeders and cat owners. This non-invasive test provides accurate results, supporting healthier breeding decisions and improved feline well-being. Protect your Domestic Shorthair with the HCM DNA test and ensure a longer, healthier life for your beloved pet. Stay informed and proactive with cutting-edge genetic testing today.

Abbreviation : HCM-DSH

Analysed mutation : MYH7 c.5647G>A

Inheritance : Autosomal Dominant

Acronym

HCM-DSH

Observed frequency

Rare

Clinical severity

Moderate

Clinical classification

Cardiovascular Diseases

Analysed mutation

MYH7 c.5647G>A
p.(E1883K)

Mode of inheritance

Autosomal Dominant (Incomplete)

Test summary:

The DNA test for Hypertrophic Cardiomyopathy (HCM) in Domestic Shorthair cats helps identify genetic mutations linked to this common heart condition. HCM causes thickening of the heart muscle, which can lead to heart failure or sudden death. Early detection through genetic testing allows breeders and owners to make informed decisions to reduce the risk of passing the disease to offspring. This test is a valuable tool in promoting the health and longevity of Domestic Shorthair cats. Regular screening combined with veterinary care is essential for managing HCM effectively.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Choose the pack that best fits your breeding or health strategy of your animals.

Understanding Hypertrophic Cardiomyopathy in Domestic Shorthair Cats

Hypertrophic Cardiomyopathy (HCM) is a common heart condition that affects cats, particularly the Domestic Shorthair breed. This genetic disorder is characterized by the thickening of the heart muscle, which can lead to various cardiovascular complications. HCM is often asymptomatic in its early stages, making it challenging for pet owners to detect without proper screening.

The Genetic Basis of HCM

HCM is primarily an inherited condition, linked to mutations in specific genes that affect the structure and function of cardiac muscle cells. In cats, mutations in the MYBPC3 gene are commonly associated with HCM. This genetic predisposition means that cats carrying these mutations have an increased risk of developing the disease, making genetic testing an invaluable tool for early detection and management.

Clinical Signs of HCM in Cats

While many cats with HCM may not show immediate symptoms, some may exhibit clinical signs as the condition progresses. Common symptoms include lethargy, difficulty breathing, decreased appetite, and sudden collapse. Pet owners should be vigilant for these signs, as early intervention can significantly improve outcomes for affected cats.

Importance of DNA Testing

DNA testing for HCM is crucial for identifying cats at risk for developing this condition. By determining whether a cat carries the genetic mutation associated with HCM, pet owners and veterinarians can make informed decisions regarding breeding, monitoring, and potential treatment options. Early identification allows for proactive management, which can enhance the quality of life for affected cats.

Management and Treatment Options

Though there is currently no cure for HCM, various management strategies can help improve a cat’s quality of life. Regular veterinary check-ups, including echocardiograms, are essential for monitoring the heart's health. In some cases, medications such as beta-blockers or calcium channel blockers may be prescribed to help manage symptoms and reduce the risk of complications.

Conclusion

Hypertrophic Cardiomyopathy is a significant health concern for Domestic Shorthair cats. Understanding the genetic basis of this condition and the importance of DNA testing can empower pet owners to take proactive steps in managing their cat's heart health. With proper monitoring and management, many cats with HCM can lead fulfilling and active lives.

Breed recognized for the test : Hypertrophic Cardiomyopathy In Domestic Shorthair (HCM-DSH)

Domestic Shorthair

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes HCM-DSH

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/HCM-DSH

Carrier - At Risk

❌ HCM-DSH/HCM-DSH

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/HCM-DSH (Carrier)

HCM-DSH/HCM-DSH (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Hypertrophic Cardiomyopathy In Domestic Shorthair (HCM-DSH) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Dominant.

Which mutation is analysed in this test?

This test analyses the mutation MYH7 c.5647G>A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Schipper Tom, Van Poucke Mario, Sonck Laurien, Smets Pascale, Ducatelle Richard, Broeckx Bart J G, Peelman Luc J. A feline orthologue of the human MYH7 c.5647G>A (p.(Glu1883Lys)) variant causes hypertrophic cardiomyopathy in a Domestic Shorthair cat. Eur J Hum Genet. 2019 Nov;27(11):1724-1730. doi: 10.1038/s41431-019-0431-4. Epub 2019 Jun 4.

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