Dog Acute Respiratory Distress Syndrome (ARDS)

Discover the benefits of a DNA test for Acute Respiratory Distress Syndrome (ARDS) in dogs, a critical condition affecting canine lung function. Early genetic screening helps identify dogs at risk, enabling timely intervention and improved treatment outcomes. Our advanced DNA test analyzes key genetic markers linked to ARDS, providing valuable insights for breeders and veterinarians. By understanding your dog's genetic predisposition, you can take proactive steps to safeguard their respiratory health. Ensure your furry friend’s well-being with accurate and reliable ARDS DNA testing. Stay ahead in canine health management with our cutting-edge genetic solutions. Protect your dog from respiratory complications today!

Abbreviation : ARDS

Analysed mutation : ANLN c.31C>T

Inheritance : Autosomal Recessive

Acronym

ARDS

Observed frequency

Rare

Clinical severity

Severe

Clinical classification

Respiratory Diseases

Analysed mutation

ANLN c.31C>T
p.(R11*)

Mode of inheritance

Autosomal Recessive

Test summary:

A DNA test for Acute Respiratory Distress Syndrome (ARDS) in dogs can help identify genetic predispositions to this severe lung condition. ARDS causes rapid inflammation and fluid buildup in the lungs, leading to breathing difficulties. Early genetic screening allows veterinarians to assess risk and tailor preventive care. Understanding a dog's genetic makeup may improve treatment outcomes and survival rates. Ongoing research aims to develop more accurate DNA tests for better diagnosis and management of ARDS in dogs.

Available from the pack : Basic

This DNA test is included starting from our pack Basic — and is also part of the packs Basic, Standard, Advanced, Complete.

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Choose the pack that best fits your breeding or health strategy of your animals.

Understanding Acute Respiratory Distress Syndrome (ARDS) in Dogs

Acute Respiratory Distress Syndrome (ARDS) is a serious condition that affects the respiratory system of dogs. It is characterized by rapid onset of severe respiratory failure, which can lead to significant morbidity and mortality if not promptly addressed. ARDS is often a secondary condition that arises from various underlying causes, including pneumonia, trauma, sepsis, or exposure to toxins.

Pathophysiology of ARDS

The pathophysiology of ARDS involves inflammation and damage to the alveolar-capillary membrane, leading to increased permeability. This results in the accumulation of fluid in the alveoli, impairing gas exchange and causing hypoxemia. The condition is marked by significant clinical signs, including labored breathing, coughing, and decreased exercise tolerance. In severe cases, affected dogs may exhibit cyanosis, lethargy, and a rapid respiratory rate.

Clinical Signs and Diagnosis

Dogs with ARDS present with a variety of clinical signs that may develop rapidly. Common symptoms include difficulty breathing, shallow or rapid respiration, coughing, and nasal discharge. A veterinarian will typically perform a thorough physical examination, coupled with diagnostic imaging such as X-rays or ultrasound to assess the lungs and rule out other conditions. Blood tests may also be conducted to evaluate the overall health status of the dog and identify potential underlying causes.

Treatment Options for ARDS

Managing ARDS in dogs requires a multifaceted approach that focuses on addressing the underlying cause and providing supportive care. Treatment may include supplemental oxygen therapy, fluid management, and medications to reduce inflammation and support lung function. In some cases, mechanical ventilation may be necessary for severely affected animals. The prognosis for dogs with ARDS varies depending on the severity of the condition and the timeliness of intervention.

Importance of DNA Testing in ARDS

While there is currently no specific DNA test for diagnosing ARDS, genetic factors may play a role in an individual dog's susceptibility to respiratory conditions. DNA testing can provide insights into hereditary health issues that may predispose dogs to ARDS or other respiratory diseases. Additionally, understanding a dog’s genetic background can help veterinarians and pet owners make informed decisions regarding breeding practices and health management.

Conclusion

Acute Respiratory Distress Syndrome is a critical condition in dogs that requires immediate veterinary attention. By understanding the underlying mechanisms, clinical signs, and treatment options, pet owners can better recognize the importance of timely intervention. While DNA testing may not directly diagnose ARDS, it can offer valuable information regarding genetic predispositions that could influence a dog's respiratory health.

Breed recognized for the test : Acute Respiratory Distress Syndrome (ARDS)

Dalmatian

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes ARDS

Genotype

Status

🟡 N/N

Non-carrier - No Risk

🟡 N/ARDS

Carrier - No Risk

❌ ARDS/ARDS

Affected - At Risk

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/ARDS (Carrier)

ARDS/ARDS (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Acute Respiratory Distress Syndrome (ARDS) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Recessive.

Which mutation is analysed in this test?

This test analyses the mutation ANLN c.31C>T.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Holopainen Saila, Hytönen Marjo K, Syrjä Pernilla, Arumilli Meharji, Järvinen AnnaKaisa, Rajamäki Minna, Lohi Hannes. ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs. PLoS Genet. 2017 Feb 21;13(2):e1006625. doi: 10.1371/journal.pgen.1006625. eCollection 2017 Feb.

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