«Таза» нені білдіреді?
Жануар мутацияны көтермейді. Бұл ауруды дамытпайды және оны өткізбейді.
мысық Дигидропиримидиназа тапшылығы (DHP)
Discover the importance of DNA testing for Dihydropyrimidinase Deficiency (DHP) in cats, a rare genetic disorder affecting pyrimidine metabolism. Early detection through a simple DNA test helps breeders and cat owners prevent the inheritance of this condition, ensuring healthier feline generations. DHP deficiency can lead to neurological issues and developmental delays, making genetic screening essential for at-risk breeds. Our comprehensive DNA test provides accurate results, supporting responsible breeding decisions. Protect your cat’s health by identifying carriers and affected cats before symptoms arise. Trust expert veterinary genetics labs for reliable DHP DNA testing. Stay proactive with genetic testing to promote long-term feline wellness.
аббревиатура: DHP
Талданатын мутация: DPYS c.1303G>A
Мұрагерлік: Аутосомды-рецессивті
Акроним
DHP
Бақыланатын жиілік
Клиникалық ауырлық
Клиникалық классификация
Метаболикалық аурулар
Талданған мутация
DPYS c.1303G>A
p.(G435R)
p.(G435R)
Мұрагерлік тәсілі
Аутосомды-рецессивті
Тест қорытындысы:
Dihydropyrimidinase Deficiency (DHP) is a rare genetic disorder that can affect cats, impacting their ability to properly break down certain amino acids. A DNA test for DHP helps identify carriers and affected cats, allowing breeders to make informed decisions. Early detection through genetic testing can prevent the breeding of affected kittens and manage the condition effectively. This test is especially important for breeds known to carry the mutation. Overall, DNA testing for DHP promotes healthier cat populations and reduces the risk of inherited metabolic issues.
Пакеттен қол жетімді: Basic
Бұл ДНҚ сынағы біздің пакеттен бастап енгізілген Basic — және де пакеттердің бөлігі болып табылады Basic, Standard, Advanced, Complete.
ДНҚ сынақ пакеттерін қарау →Жануарларыңызды өсіру немесе денсаулық стратегияңызға сәйкес келетін қаптаманы таңдаңыз.
Understanding Dihydropyrimidinase Deficiency (DHP)
Dihydropyrimidinase Deficiency (DHP) is a rare genetic disorder that affects the metabolism of pyrimidines in cats. This condition is caused by a mutation in the gene responsible for encoding the enzyme dihydropyrimidinase, which plays a crucial role in the breakdown of pyrimidine compounds. When this enzyme is deficient or absent, it leads to the accumulation of toxic metabolites that can cause various health issues in affected cats.
Клиникалық белгілері мен белгілері
Cats with Dihydropyrimidinase Deficiency may exhibit a range of clinical signs, which can vary in severity. Common symptoms include neurological issues such as seizures, ataxia (loss of coordination), and behavioral changes. Additionally, affected cats may suffer from gastrointestinal problems, such as diarrhea and vomiting, due to the buildup of toxic substances in their systems. These symptoms often manifest in early life, making early diagnosis crucial for managing the condition effectively.
Diagnosis of DHP
Diagnosis of Dihydropyrimidinase Deficiency typically involves a combination of clinical evaluation and genetic testing. Veterinarians may assess the cat's clinical signs and consider the possibility of DHP based on the observed symptoms. Genetic testing can confirm the presence of mutations in the dihydropyrimidinase gene, allowing for a definitive diagnosis. Early detection is important for managing the condition and implementing appropriate care strategies.
Басқару және емдеу
Currently, there is no specific cure for Dihydropyrimidinase Deficiency. Management of the condition focuses on alleviating symptoms and improving the quality of life for affected cats. This may involve dietary modifications to reduce the intake of pyrimidines, supportive care for neurological symptoms, and regular monitoring of the cat's health. Collaboration between veterinarians and pet owners is essential in developing a tailored care plan that addresses the unique needs of each affected cat.
Prognosis and Long-term Outlook
The long-term prognosis for cats with Dihydropyrimidinase Deficiency can vary significantly based on the severity of symptoms and the effectiveness of management strategies. Some cats may lead relatively normal lives with appropriate care, while others may experience more severe neurological deficits that impact their overall well-being. Regular veterinary check-ups and proactive care are vital to ensuring the best possible outcome for these cats.
Қорытынды
Dihydropyrimidinase Deficiency is a serious genetic condition that can significantly affect a cat's health and quality of life. Understanding the disease, recognizing its symptoms, and seeking timely diagnosis and management are critical for pet owners. Through education and collaboration with veterinary professionals, affected cats can receive the care they need to thrive despite their diagnosis.
Сынақ үшін танылған тұқым: Дигидропиримидиназа тапшылығы (DHP)
- Abyssinian
- Aegean
- Alpine Lynx
- Altai
- American Bobtail
- American Bobtail Longhair
- American Bobtail Shorthair
- American Burmese
- American Curl
- American Curl Longhair
- American Curl Shorthair
- American Fold Longhair
- American Fold Shorthair
- American Keuda
- American Longhair
- American Lynx
- American Miniature Cat
- American Polydactyl
- American Ringtail
- American Shorthair
- American Straight Long Hair
- American Straight Shorthair
- American Wirehair
- Anatoli
- Aphrodite
- Aphrodite Giant
- Aphrodite's Giant Longhair
- Aphrodite's Giant Shorthair
- Arabian Mau
- Asian
- Asian Leopard Cat
- Asian Longhair
- Asian Semi-longhair
- Asian Shorthair
- Australian Bombay
- Australian Mist
- Aztec
- Balinese
- Bambino
- Bambino Curl
- BamBob
- Bengal
- Bengal Longhair
- Birman
- Bobcat
- Bohemian Rex
- Bombay
- Bramble
- Brazilian Shorthair
- Bristol
- British Ice Longhair
- British Ice Shorthair
- British Longhair
- British Shorthair
- Burmese
- Burmese European
- Burmese Longhair
- Burmilla
- Burmilla Longhair
- Burmilla Shorthair
- California Spangled
- California Toyger
- Californian Rex
- Canadian Feral Cat
- Canadian Sphynx
- Caracal
- Celtic
- Celtic Shorthair
- Ceylon
- Chantilly-Tiffany
- Chartreux
- Chausie
- Chinchilla Longhair
- Chinese Harlequin
- Chinese Li Hua
- Chinese Tank Cat
- Classicat
- Colorpoint Shorthair
- Companion Cat
- Copper
- Cornish Rex
- Cornish Rex Longhair
- Curly Tail Cat
- Cymric
- Cyprus
- Desert Lynx
- Deutsch Langhaar
- Devon Rex
- Domestic Longhair
- Domestic medium-haired
- Domestic Shorthair
- Don Sphynx
- Donskoy
- Dossow
- Dragon Li
- Dwelf
- Egyptian Mau
- Elf
- European
- European Burmese
- European Shorthair
- Exotic
- Exotic Shorthair
- Experimental
- Fishing Cat
- Foldex
- Foreign White
- Foreign White Longhair
- Foreign White Shorthair
- Gao Taem
- Genetta
- Geoffroy's Cat
- German Longhair
- German Rex
- Havana
- Havana Brown
- Hemingway Curl
- Hibernian Lynx
- Highland Fold
- Highland Lynx
- Highland Straight
- Highlander
- Highlander Longhair
- Highlander Shorthair
- Himalayan
- House Cat Longhair
- House Cat Shorthair
- Household Pet
- Household Pet Kitten
- Household Pet Longhair
- Household Pet Shorthair
- Isle of Man Longhair
- Isle of Man Shorthair
- Jaguarette
- Jaguarundi Curl
- Japanese Bobtail
- Japanese Bobtail Longhair
- Japanese Bobtail Shorthair
- Japanese domestic
- Javanese
- Jungala
- Jungle Cat
- Jungle Curl
- Jungle Lynx
- Junglebob
- Kanaani
- Karelian Bobtail
- Karelian Bobtail Longhair
- Khao Manee
- Khaomanee
- Kinkalow
- Korat
- Korean Bobtail
- Korn Ja
- Kurilian Bobtail
- Kurilian Bobtail Longhair
- Kurilian Bobtail Shorthair
- Lambkin
- LaPerm
- LaPerm Longhair
- LaPerm Shorthair
- Lykoi
- Maine Coon
- Maine Coon Polydactyl
- Manx
- Manx Longhair
- Manx Shorthair
- Me-kong Bobtail
- Meerkat
- Mekong Bobtail
- Minskin
- Minuet
- Minuet Longhair
- Mixed Breed
- Mohave Bob
- Mojave Spotted
- Mokave Jag Cat
- Mountain Bob
- Munchkin
- Munchkin Longhair
- Napoleon
- Nebelung
- Neva Masquerade
- Niebelung
- Non Recognized Hairless
- Non Recognized Longhair
- Non Recognized Shorthair
- Norwegian Forest Cat
- Ocicat
- Ojos Azules
- Oregon Rex (extinct)
- Oriental
- Oriental Bicolor
- Oriental Longhair
- Oriental Shorthair
- Original Longhair
- Owyhee Bob
- Pantherette
- Persian
- Peterbald
- Pharaoh
- Pixiebob
- Pixiebob Longhair
- Puppykat
- Raas
- Ragamuffin
- Ragdoll
- Ruffle
- Russian
- Russian Black
- Russian Blue
- Russian Tabby
- Russian White
- Rusty Spotted Cat
- Sacred Birman
- Safari
- Sam Sawet
- Sashkin Rex
- Savannah
- Scottish Fold
- Scottish Fold Longhair
- Scottish Longhair
- Scottish Shorthair
- Scottish Straight
- Scottish Straight Longhair
- Selkirk Rex
- Selkirk Rex Longhair
- Selkirk Rex Shorthair
- Selkirk Straight
- Serengeti
- Serrade Petit
- Serval
- Siamese
- Siamese Longhair
- Siberian
- Singapura
- Skookum
- Snowbob
- Snowshoe
- Sokoke
- Somali
- Sphynx
- Suffolk
- Suphalak
- Tennessee Bobtail
- Tennessee Rex
- Thai
- Thai Blue Point
- Thai Lilac
- Thai Lilac Point
- Tiffanie
- Tigrette
- Tonkinese
- Tonkinese Longhair
- Tonkinese Shorthair
- Toybob
- Toyger
- Traditional Siamese
- Transylvanian
- Tundra
- Turkish Angora
- Turkish Van
- Turkish Vankedisi
- Ukrainian Levkoy
- Unknown
- Ural Rex
- Ural Rex Longhair
- Vienna Woods
- Viverral
- York Chocolate
🧬 Interpretation of genotypes DHP
Генотип
Күй
🟡 N/N
Тасымалдаушы емес - Тәуекел жоқ
🟡 N/DHP
Тасымалдаушы - Тәуекел жоқ
❌ DHP/DHP
Зардап шеккен - Тәуекелде
Жиі қойылатын сұрақтар: түсіндіруді түсіну
«Тасымалдаушы» ауыр ма?
Жоқ. Жануар әдетте сау, бірақ мутацияны оған бере алады ұрпақ.
Егер жануар «зардап шеккен» болса ше?
Ол мутацияланған екі көшірмені алып жүреді. Клиникалық белгілерге байланысты күтіледі ауру. Оны өсіруге болмайды.
Неліктен ерлер мен әйелдер арасында айырмашылықтар бар?
Кейбір аурулар жынысқа байланысты, сондықтан олардың көрінісі әртүрлі жануардың жынысы.
Ұрпақты болжау
N/N (%d1%82%d0%b0%d1%81%d1%8b%d0%bc%d0%b0%d0%bb%d0%b4%d0%b0%d1%83%d1%88%d1%8b-%d0%b5%d0%bc%d0%b5%d1%81)
N/DHP (Тасымалдаушы)
DHP/DHP (Әсер еткен)
ДНҚ сынағы жиі қойылатын сұрақтар
Бұл ДНҚ сынағы нені анықтайды?
This DNA test detects the mutation associated with Dihydropyrimidinase Deficiency (DHP) in order to identify clear, carrier, or at-risk animals.
Неліктен асыл тұқымды жануарды сынау керек?
ДНҚ сынағы селекционерлерге қауіпсіз жұптасуды жоспарлауға және мутацияны ұрпаққа беру қаупін азайтуға көмектеседі.
Бұл сынақтың тұқым қуалау режимі қандай?
Бұл сынақ үшін хабарланған тұқым қуалау режимі аутосомды рецессивті болып табылады.
Бұл сынақта қандай мутация талданады?
This test analyses the mutation DPYS c.1303G>A.
Тасымалдаушы жануар міндетті түрде зардап шегеді ме?
Міндетті емес. Интерпретация тұқым қуалаушылық үлгісіне және алынған генотипке байланысты.
Анықтамалар
Chang HyeSook, Shibata Takako, Arai Satoshi, Zhang Chunhua, Yabuki Akira, Mitani Sawane, Higo Takashi, Sunagawa Kazuhiro, Mizukami Keijiro, Yamato Osamu. Dihydropyrimidinase deficiency: the first feline case of dihydropyrimidinuria with clinical and molecular findings. JIMD Rep. 2012;6:21-6. doi: 10.1007/8904_2012_139. Epub 2012 Mar 29.