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Ит Дегенеративті миелопатия (DM SOD1A)
Degenerative Myelopathy (DM) is a progressive neurological disorder affecting dogs, often leading to mobility loss. A DNA test for DM can help identify carriers and affected breeds, enabling early intervention and better management of the condition. This genetic testing is particularly crucial for breeds like German Shepherds, Boxers, and Pembroke Welsh Corgis, which are more susceptible. By understanding a dog's genetic predisposition to DM, pet owners can make informed decisions about their care and breeding. Regular veterinary check-ups and lifestyle adjustments can further support dogs at risk. If you suspect your dog might be affected, consider a DNA test for peace of mind and proactive health management. Stay informed and protect your furry friend's mobility with a simple DNA test today!
аббревиатура: DM SOD1A
Талданатын мутация: SOD1 c.118G>A
Мұрагерлік: Аутосомды-рецессивті
Акроним
DM SOD1A
Бақыланатын жиілік
Клиникалық ауырлық
Клиникалық классификация
Неврологиялық аурулар
Талданған мутация
SOD1 c.118G>A
p.(E40K)
p.(E40K)
Мұрагерлік тәсілі
Аутосомды-рецессивті (Аяқталмаған)
Тест қорытындысы:
Degenerative Myelopathy (DM) is a progressive neurological disorder affecting dogs, often leading to loss of coordination and mobility. A DNA test can identify if a dog carries the genetic mutation associated with this condition, allowing for early detection and management. Breeds such as German Shepherds, Boxers, and Pembroke Welsh Corgis are particularly susceptible to DM. Knowing a dog's genetic status can help owners make informed decisions regarding breeding and care. Early intervention and supportive therapies can improve the quality of life for affected dogs.
Пакеттен қол жетімді: Basic
Бұл ДНҚ сынағы біздің пакеттен бастап енгізілген Basic — және де пакеттердің бөлігі болып табылады Basic, Standard, Advanced, Complete.
ДНҚ сынақ пакеттерін қарау →Жануарларыңызды өсіру немесе денсаулық стратегияңызға сәйкес келетін қаптаманы таңдаңыз.
Understanding Degenerative Myelopathy (DM) in Dogs
Degenerative Myelopathy (DM) is a progressive neurological disorder that affects the spinal cord of dogs, leading to a gradual loss of mobility and coordination. It is primarily characterized by the degeneration of the spinal cord’s white matter, which impacts the transmission of nerve signals between the brain and the rest of the body. This condition typically manifests in older dogs, often after the age of eight, and can severely impact their quality of life.
Symptoms of Degenerative Myelopathy
The onset of DM is usually subtle, with early signs including difficulty in coordinating movements, particularly in the hind limbs. As the disease progresses, dogs may exhibit symptoms such as dragging their back paws, weakness in the hind legs, and a loss of balance. Eventually, affected dogs may become unable to walk and may require assistance with mobility. The progression of the disease can vary significantly from one individual to another.
The Role of DNA Testing in Diagnosing DM
DNA testing for Degenerative Myelopathy is a crucial tool for diagnosing the condition, particularly in asymptomatic dogs or those showing early signs of the disease. The test detects the presence of a specific mutation in the SOD1 gene, which is associated with the development of DM. A positive result indicates that the dog carries the mutation, which significantly increases the risk of developing the disease. This information can be invaluable for breeders and pet owners in making informed decisions about breeding and management.
Importance of Early Detection
Early detection of DM through DNA testing allows for better management of the condition. While there is currently no cure for DM, knowing a dog's genetic predisposition can help owners prepare for potential mobility challenges. This knowledge enables proactive measures such as physical therapy, weight management, and home modifications to accommodate the dog’s changing needs. Additionally, responsible breeding practices can be promoted to reduce the prevalence of DM in future generations.
Қорытынды
Degenerative Myelopathy is a serious condition that affects many dogs, leading to significant mobility issues. DNA testing for this disorder serves as an essential step in understanding and managing the risks associated with DM. By identifying carriers of the disease, dog owners and breeders can take informed actions to support affected dogs and contribute to the long-term health of canine populations.
Сынақ үшін танылған тұқым: Дегенеративті миелопатия (DM SOD1A)
- Airedale Terrier
- Alaskan Malamute
- American Bulldog
- American Bully
- American Cocker Spaniel
- American English Coonhound
- American Eskimo Dog
- American Foxhound
- American Hairless Terrier
- American Pit Bull Terrier
- American Staffordshire Terrier
- American Water Spaniel
- American White Shepherd Dog
- Anatolian Shepherd Dog
- Aussiedoodle
- Australian Cobberdog
- Australian Kelpie
- Australian Koolie
- Australian Shepherd
- Australian Stumpy Tail Cattle Dog
- Australian Terrier
- Austrian Standard Pinscher
- Beagle
- Bearded Collie
- Belgian Malinois
- Belgian Sheepdog
- Belgian Shepherd Dog
- Bernedoodle
- Bernese Mountain Dog
- Bichon Frisé
- Biewer Terrier
- Black and Tan Coonhound
- Black Cocker Spaniel
- Bloodhound
- Blue Heeler
- Bluetick Coonhound
- Bohemian Wire-Haired Pointing Griffon
- Border Collie
- Border Terrier
- Bordoodle
- Borzoi
- Boston Terrier
- Boxer
- Boykin Spaniel
- Brussels, Standard Griffon
- Bulldog
- Bullmastiff
- Canaan Dog
- Cardigan Welsh Corgi
- Carlin Pinscher
- Carolina Dog
- Catahoula Leopard Dog
- Cavalier King Charles Spaniel
- Cavapoo
- Cavapoochon
- Cesky Fousek
- Chesapeake Bay Retriever
- Chihuahua
- Chinese Crested
- Chow Chow
- Clumber Spaniel
- Cockapoo
- Coton de Tulear
- Czechoslovakian Wolfdog
- Dalmatian
- Danoodle
- Decker Terrier
- Deutscher Wachtelhund
- Doberman Pinscher
- Dogo Argentino
- Dutch Shepherd
- East Siberian Laika
- English Cocker Spaniel
- English Coonhound
- English Shepherd
- English Springer Spaniel
- English Toy Spaniel
- Farm Collie
- Finnish Lapphund
- Finnish Spitz
- Flat-Coated Retriever
- Fox Terrier
- French Bulldog
- German Pinscher
- German Shepherd Dog
- German Shorthaired Pointer
- German Wirehaired Pointer
- Giant Schnauzer
- Golden Retriever
- Goldendoodle
- Gordon Setter
- Great Pyrenees
- Greyhound
- Harrier
- Hovawart
- Irish Red and White Setter
- Irish Setter
- Irish Soft Coated Wheaten Terrier
- Irish Terrier
- Irish Wolfhound
- Irishdoodle
- Jack Russell Terrier
- Keeshond
- Kerry Blue Terrier
- King Shepherd
- Komondor
- Koolie
- Kuvasz
- Lab/Golden Cross
- Labradoodle
- Labrador Retriever
- Lakenois
- Lancashire Heeler
- Landseer Newfoundland
- Lapponian Herder
- Lucas Terrier
- Maltipoo
- Maremma Sheepdog
- Mastiff
- Miniature American Shepherd
- Miniature Australian Shepherd Dog
- Miniature Fox Terrier
- Miniature Poodle
- Miniature Schnauzer
- Mountain Cur
- Newfoundland
- Newfypoo
- Norfolk Terrier
- Norwich Terrier
- Nova Scotia Duck Tolling Retriever
- Old English Sheepdog
- Old Farm Collie
- Olde English Bulldogge
- Parson Russell Terrier
- Patterdale Terrier
- Pembroke Welsh Corgi
- Peruvian Hairless Dog
- Pharaoh Hound
- Plott Hound
- Pointer
- Pomeranian
- Pomsky
- Poodle
- Portuguese Podengo
- Portuguese Podengo Pequeno
- Pug
- Puli
- Pumi
- Rat Terrier
- Redbone Coonhound
- Redtick Coonhound
- Rhodesian Ridgeback
- Rottweiler
- Rough Collie
- Russell Terrier
- Russian Wolfhound
- Saarloos Wolfhond
- Saint Bernard
- Saluki
- Samoyed
- Schnoodle
- Scottish Collie
- Scottish Rough Collie
- Scottish Smooth Collie
- Sealyham Terrier
- Serbian Balkan Hound
- Serbian Balkan Standard Hound
- Sheepadoodle
- Shetland Sheepdog
- Shih Tzu
- Shiloh Shepherd
- Shorty Bull
- Siberian Husky
- Silken Windhound
- Silky Terrier
- Smooth Collie
- Smooth Fox Terrier
- Stabyhoun
- Staffordshire Bull Terrier
- Swedish Lapphund
- Swiss White Shepherd Dog
- Tamaskan Dog
- Tamaskan Husky
- Teddy Roosevelt Terrier
- Tenterfield Terrier
- Tibetan Terrier
- Toy Australian Shepherd Dog
- Toy Fox Terrier
- Toy Poodle
- Treeing Walker Coonhound
- UK Breed Council Labrador Retriever
- Welsh Cocker Spaniel
- Welsh Springer Spaniel
- Welsh Terrier
- West Siberian Laika
- Whippet
- Wire Fox Terrier
- Wirehaired Pointing Griffon
- Working Cocker Spaniel
- Working Kelpie
- Yorkiepoo
- Yorkshire Terrier
🧬 Interpretation of genotypes DM SOD1A
Генотип
Күй
🟡 N/N
Тасымалдаушы емес - Тәуекел жоқ
🟡 N/DM SOD1A
Тасымалдаушы - Тәуекел жоқ
❌ DM SOD1A/DM SOD1A
Зардап шеккен - Тәуекелде
Жиі қойылатын сұрақтар: түсіндіруді түсіну
«Тасымалдаушы» ауыр ма?
Жоқ. Жануар әдетте сау, бірақ мутацияны оған бере алады ұрпақ.
Егер жануар «зардап шеккен» болса ше?
Ол мутацияланған екі көшірмені алып жүреді. Клиникалық белгілерге байланысты күтіледі ауру. Оны өсіруге болмайды.
Неліктен ерлер мен әйелдер арасында айырмашылықтар бар?
Кейбір аурулар жынысқа байланысты, сондықтан олардың көрінісі әртүрлі жануардың жынысы.
Ұрпақты болжау
N/N (%d1%82%d0%b0%d1%81%d1%8b%d0%bc%d0%b0%d0%bb%d0%b4%d0%b0%d1%83%d1%88%d1%8b-%d0%b5%d0%bc%d0%b5%d1%81)
N/DM SOD1A (Тасымалдаушы)
DM SOD1A/DM SOD1A (Әсер еткен)
ДНҚ сынағы жиі қойылатын сұрақтар
Бұл ДНҚ сынағы нені анықтайды?
This DNA test detects the mutation associated with Degenerative Myelopathy (DM) in order to identify clear, carrier, or at-risk animals.
Неліктен асыл тұқымды жануарды сынау керек?
ДНҚ сынағы селекционерлерге қауіпсіз жұптасуды жоспарлауға және мутацияны ұрпаққа беру қаупін азайтуға көмектеседі.
Бұл сынақтың тұқым қуалау режимі қандай?
Бұл сынақ үшін хабарланған тұқым қуалау режимі аутосомды рецессивті болып табылады.
Бұл сынақта қандай мутация талданады?
This test analyses the mutation SOD1 c.118G>A.
Тасымалдаушы жануар міндетті түрде зардап шегеді ме?
Міндетті емес. Интерпретация тұқым қуалаушылық үлгісіне және алынған генотипке байланысты.
Анықтамалар
Awano Tomoyuki, Johnson Gary S, Wade Claire M, Katz Martin L, Johnson Gayle C, Taylor Jeremy F, Perloski Michele, Biagi Tara, Baranowska Izabella, Long Sam, March Philip A, Olby Natasha J, Shelton G Diane, Khan Shahnawaz, O'Brien Dennis P, LindbladToh Kerstin, Coates Joan R. Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2794-9. doi: 10.1073/pnas.0812297106. Epub 2009 Feb 2.