「クリア」とはどういう意味ですか？
その動物は突然変異を持っていません。病気を発症することはありません そしてそれを伝えません。
犬 中央アジアのシェパードにおける異栄養性表皮水疱症（DEB-CAS）
Dystrophic Epidermolysis Bullosa (DEB) is a serious genetic skin disorder affecting Central Asian Shepherd dogs, causing fragile skin and painful blistering. DNA testing for DEB in Central Asian Shepherds is essential for responsible breeders to identify carriers and prevent passing this debilitating condition to puppies. Early genetic screening helps maintain the health and quality of the breed by reducing the risk of affected offspring. By using a reliable DEB DNA test, breeders can make informed mating decisions and promote the welfare of Central Asian Shepherd dogs. Protect your dog’s future with accurate DEB genetic testing today. Ensure your Central Asian Shepherd’s health with proactive DNA screening for Dystrophic Epidermolysis Bullosa.
略語 ： DEB-CAS
解析された変異: COL7A1 c.4579C>T
継承 ： 常染色体劣性
頭字語
DEB-CAS
観測周波数
臨床的重症度
臨床分類
皮膚疾患
解析された変異
COL7A1 c.4579C>T
p.(R1527*)
p.(R1527*)
継承のモード
常染色体劣性
テストの概要:
Dystrophic Epidermolysis Bullosa (DEB) is a genetic skin disorder affecting Central Asian Shepherd dogs, causing fragile skin that blisters and scars easily. A DNA test can identify carriers and affected dogs by detecting mutations in the COL7A1 gene responsible for DEB. Early genetic screening helps breeders make informed decisions to reduce the incidence of this painful condition. By using DNA testing, the health and welfare of future generations of Central Asian Shepherds can be significantly improved. Responsible breeding practices are essential to managing DEB in this breed.
パックから入手可能: Basic
この DNA 検査はパックから含まれています Basic — これもパックの一部です Basic, Standard, Advanced, Complete。
DNA テスト パックを見る →動物の繁殖戦略や健康戦略に最適なパックをお選びください。
Understanding Dystrophic Epidermolysis Bullosa (DEB) in Dogs
Dystrophic Epidermolysis Bullosa (DEB) is a genetic skin disorder that affects the integrity of the skin in dogs, particularly noted in certain breeds like the Central Asian Shepherd. This condition is characterized by extreme fragility of the skin and mucous membranes, leading to blister formation and erosions following minimal trauma. DEB results from mutations in the genes responsible for producing collagen, a protein that provides structure and strength to the skin.
Clinical Features of DEB
Dogs affected by DEB typically exhibit symptoms such as blistering, ulceration, and scarring on their skin. These lesions can be painful and may lead to secondary infections. The condition can significantly impact the quality of life for affected dogs, as the skin's ability to heal is compromised. Additionally, the severity of DEB can vary, with some dogs experiencing mild symptoms while others may have more severe manifestations requiring ongoing management.
Genetic Basis of DEB
The underlying cause of Dystrophic Epidermolysis Bullosa is primarily linked to mutations in the COL7A1 gene, which encodes type VII collagen. This collagen is crucial for anchoring the outer layer of the skin to the underlying tissue, and deficiencies can lead to the symptoms associated with DEB. The genetic nature of this condition means it can be inherited, making awareness of the genetic background in breeding practices essential to reduce the incidence of DEB in future generations.
罹患犬の管理とケア
While there is currently no cure for Dystrophic Epidermolysis Bullosa, management strategies focus on minimizing discomfort and preventing complications. This may include providing a soft, padded environment to reduce friction and trauma to the skin, as well as regular veterinary check-ups to monitor skin condition and address any infections. Nutritional support and proper wound care are also vital components of managing affected dogs to improve their overall well-being.
DNA検査の重要性
DNA testing plays a crucial role in identifying carriers of the gene mutation responsible for DEB. By conducting genetic tests, breeders can make informed decisions to avoid producing affected puppies and thus contribute to reducing the prevalence of this condition in the breed. Additionally, early identification of affected individuals allows for timely intervention and management strategies to enhance their quality of life.
試験に認められた品種: 中央アジアのシェパードにおける異栄養性表皮水疱症（DEB-CAS）
- Central Asian Shepherd Dog
🧬 Interpretation of genotypes DEB-CAS
遺伝子型
状態
🟡 N/N
ノンキャリア - リスクなし
🟡 N/DEB-CAS
キャリア - リスクなし
❌ DEB-CAS/DEB-CAS
影響を受ける – 危険にさらされる
FAQ: 解釈を理解する
「キャリア」って本気なの？
いいえ、その動物は通常健康ですが、突然変異をその動物に伝える可能性があります。 子孫。
動物が「影響を受けている」場合はどうなりますか?
それは2つの突然変異したコピーを持っています。臨床症状は以下に応じて予想されます 病気。飼育してはいけません。
なぜ男性/女性で違いがあるのでしょうか？
一部の病気は性と関連があるため、その発現は性別によって異なります。 動物の性別。
子孫を予測する
N/N (%e3%83%8e%e3%83%b3%e3%82%ad%e3%83%a3%e3%83%aa%e3%82%a2）
N/DEB-CAS (キャリア）
DEB-CAS/DEB-CAS (影響を受ける）
DNA検査に関するよくある質問
この DNA 検査では何が検出されますか?
This DNA test detects the mutation associated with Dystrophic Epidermolysis Bullosa In Central Asian Shepherd (DEB-CAS) in order to identify clear, carrier, or at-risk animals.
なぜ繁殖動物を検査するのでしょうか?
DNA検査は、ブリーダーがより安全な交配を計画し、子孫に突然変異が伝わるリスクを軽減するのに役立ちます。
このテストの継承モードは何ですか?
このテストで報告される継承モードは常染色体劣性です。
このテストではどの変異が分析されますか?
This test analyses the mutation COL7A1 c.4579C>T.
保菌動物は必ず影響を受けますか?
必ずしもそうとは限りません。解釈は、遺伝パターンと結果として生じる遺伝子型によって異なります。
参考文献
Niskanen Julia, Dillard Kati, Arumilli Meharji, Salmela Elina, Anttila Marjukka, Lohi Hannes, Hytönen Marjo K. Nonsense variant in COL7A1 causes recessive dystrophic epidermolysis bullosa in Central Asian Shepherd dogs. PLoS One. 2017 May 11;12(5):e0177527. doi: 10.1371/journal.pone.0177527. eCollection 2017.